More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair

(2011) Irene Chiolo et al.   CELL

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

(2011) S S Devgan et al.   CELL DEATH AND DIFFERENTIATION

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells

(2011) Y. Ichijima et al.   GENES & DEVELOPMENT

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

(2011) Céline Baldeyron et al.   JOURNAL OF CELL BIOLOGY

MDC1 collaborates with TopBP1 in DNA replication checkpoint control

(2011) Jiadong Wang et al.   JOURNAL OF CELL BIOLOGY

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

(2011) Anne Bothmer et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

(2011) Marieke H. Peuscher et al.   NATURE CELL BIOLOGY

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Chfr and RNF8 synergistically regulate ATM activation

(2011) Jiaxue Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

(2011) Ildiko Hajdu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome

(2011) Toshiyuki Bohgaki et al.   PLoS Genetics

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells

(2010) Guillaume J. Filion et al.   CELL

Dephosphorylation of γ-H2AX by WIP1: An important homeostatic regulatory event in DNA repair and cell cycle control

(2010) Sung-Hwan Moon et al.   CELL CYCLE

MDC1: The art of keeping things in focus

(2010) Stephanie Jungmichel et al.   CHROMOSOMA

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

(2010) Caroline E Lilley et al.   EMBO JOURNAL

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

(2010) Rachele Cescutti et al.   EMBO JOURNAL

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

(2010) Ye Xu et al.   JOURNAL OF CELL BIOLOGY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

A guide to super-resolution fluorescence microscopy

(2010) Lothar Schermelleh et al.   JOURNAL OF CELL BIOLOGY

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

(2010) Anne Bothmer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

(2010) S. Facchino et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

(2010) Zuzana Jasencakova et al.   MOLECULAR CELL

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1

(2010) Michael S.Y. Huen et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes

(2010) Beth A. Helmink et al.   NATURE

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells

(2010) Sophia B. Chernikova et al.   RADIATION RESEARCH

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

(2009) Rodrigo Bermejo et al.   CELL

Assembly of multiprotein complexes that control genome function: Figure 1.

(2009) Christoffel Dinant et al.   JOURNAL OF CELL BIOLOGY

Heterochromatin protein 1 is recruited to various types of DNA damage

(2009) Martijn S. Luijsterburg et al.   JOURNAL OF CELL BIOLOGY

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

A Selective Requirement for 53BP1 in the Biological Response to Genomic Instability Induced by Brca1 Deficiency

(2009) Liu Cao et al.   MOLECULAR CELL

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

(2009) Joanna R. Morris et al.   NATURE

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

(2009) Guang Peng et al.   NATURE CELL BIOLOGY

OsHAL3 mediates a new pathway in the light-regulated growth of rice

(2009) Shi-Yong Sun et al.   NATURE CELL BIOLOGY

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1

(2009) Kenji Watanabe et al.   NUCLEIC ACIDS RESEARCH

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response

(2008) J. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island

(2008) Heather M. O'Hagan et al.   PLoS Genetics