Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

(2012) C. Canugovi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Histone H2A.X as an Early Marker of Neuronal Endangerment following Seizures in the Adult Rat Brain

(2011) S. L. Crowe et al.   JOURNAL OF NEUROSCIENCE

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Amyloid- /Fyn-Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease

(2011) E. D. Roberson et al.   JOURNAL OF NEUROSCIENCE

ATM controls meiotic double-strand-break formation

(2011) Julian Lange et al.   NATURE

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Epigenetic Mechanisms in Cognition

(2011) Jeremy J. Day et al.   NEURON

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes

(2011) Johannes Gräff et al.   PHYSIOLOGICAL REVIEWS

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

(2011) R. N. Fernando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Neurons Efficiently Repair Glutamate-induced Oxidative DNA Damage by a Process Involving CREB-mediated Up-regulation of Apurinic Endonuclease 1

(2010) Jenq-Lin Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone XH2AX Is Required forXenopusAnterior Neural Development

(2010) Sung-Young Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

(2010) Moustapha Cissé et al.   NATURE

Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

(2010) Alexxai V. Kravitz et al.   NATURE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Transsynaptic Progression of Amyloid-β-Induced Neuronal Dysfunction within the Entorhinal-Hippocampal Network

(2010) Julie A. Harris et al.   NEURON

Inducible response required for repair of low-dose radiation damage in human fibroblasts

(2010) S. Grudzenski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS

(2009) E. R.P. Shull et al.   GENES & DEVELOPMENT

Microscopic imaging of DNA repair foci in irradiated normal tissues

(2009) Nirmal Bhogal et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

(2009) Bu Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Collagen VI protects neurons against Aβ toxicity

(2009) Jason S Cheng et al.   NATURE NEUROSCIENCE

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases

(2008) Ivona Brasnjevic et al.   DNA REPAIR

Nucleic acid oxidation in Alzheimer disease

(2008) Paula I. Moreira et al.   FREE RADICAL BIOLOGY AND MEDICINE

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

(2008) Hyoung-gon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

(2008) Dohoon Kim et al.   NEURON

The γ-H2A.X: Is it just a surrogate marker of double-strand breaks or much more?

(2007) Ismail Hassan Ismail et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS