Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

(2012) Joanna B. Strosznajder et al.   MOLECULAR NEUROBIOLOGY

Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk

(2012) Karolien Bettens et al.   Molecular Neurodegeneration

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

(2012) C Pottier et al.   MOLECULAR PSYCHIATRY

Stopping a thief and killer: Alzheimer's disease crisis demands greater commitment to research

(2011) William Thies   Alzheimers & Dementia

The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception

(2011) Michael W. Weiner et al.   Alzheimers & Dementia

Signaling Mechanism of Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Inflammatory Diseases

(2011) Xueqing Ba et al.   AMERICAN JOURNAL OF PATHOLOGY

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases

(2011) Hon-Cheong So et al.   GENETIC EPIDEMIOLOGY

Exome sequencing and subsequent association studies identify five amino acid-altering variants influencing human height

(2011) Jae-Jung Kim et al.   HUMAN GENETICS

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

(2011) Tiina M Kauppinen et al.   Journal of Neuroinflammation

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

A rare variant in MYH6 is associated with high risk of sick sinus syndrome

(2011) Hilma Holm et al.   NATURE GENETICS

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

(2011) Gregory M. Cooper et al.   NATURE REVIEWS GENETICS

Exome sequencing reveals an unexpected genetic cause of disease: NOTCH3 mutation in a Turkish family with Alzheimer's disease

(2011) Rita João Guerreiro et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

(2010) Andrew J. Saykin et al.   Alzheimers & Dementia

Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

(2010) Gyungah Jun   ARCHIVES OF NEUROLOGY

Heredity in dementia of the Alzheimer type

(2010) A. L. Mina Bergem   CLINICAL GENETICS

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The CARMA3-Bcl10-MALT1 Signalosome Promotes Angiotensin II-dependent Vascular Inflammation and Atherogenesis

(2010) Linda M. McAllister-Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease

(2010) Hsin-Ping Liu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Longitudinal MRI atrophy biomarkers: Relationship to conversion in the ADNI cohort

(2010) Shannon L. Risacher et al.   NEUROBIOLOGY OF AGING

Genome-wide association study of CSF biomarkers A 1-42, t-tau, and p-tau181p in the ADNI cohort

(2010) S. Kim et al.   NEUROLOGY

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

(2009) Gary W. Beecham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mild Cognitive Impairment

(2009) Ronald C. Petersen et al.   ARCHIVES OF NEUROLOGY

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Baseline MRI Predictors of Conversion from MCI to Probable AD in the ADNI Cohort

(2009) Shannon Risacher et al.   Current Alzheimer Research

PolyADP-ribosylation is required for long-term memory formation in mammals

(2009) Shmuel Goldberg et al.   JOURNAL OF NEUROCHEMISTRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Exome sequencing identifies the cause of a mendelian disorder

(2009) Sarah B Ng et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

The Allen Brain Atlas: 5 years and beyond

(2009) Allan R. Jones et al.   NATURE REVIEWS NEUROSCIENCE

Genetic diagnosis by whole exome capture and massively parallel DNA sequencing

(2009) Murim Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

(2008) Richard Abraham et al.   BMC Medical Genomics

The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods

(2008) Clifford R. Jack et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE