The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Altered Subcellular Distribution of c-Abl in Alzheimer's Disease

(2017) Zheng Jing et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Mitochondria are required for pro‐ageing features of the senescent phenotype

(2016) Clara Correia‐Melo et al.   EMBO JOURNAL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Neuronal accumulation of unrepaired DNA in a novel specific chromatin domain: structural, molecular and transcriptional characterization

(2016) Jorge Mata-Garrido et al.   Acta Neuropathologica Communications

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

Cellular senescence and the aging brain

(2015) Shankar J. Chinta et al.   EXPERIMENTAL GERONTOLOGY

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

(2015) Julie E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology

(2015) Julie E. Simpson et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Mitochondrial retrograde signaling regulates neuronal function

(2015) Umut Cagin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress

(2015) H Yang et al.   Cell Death & Disease

DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

(2015) Elsa Suberbielle et al.   Nature Communications

P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition

(2015) Yanhong Zhang et al.   Oncotarget

Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A

(2015) Takuya Kumazawa et al.   Scientific Reports

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

(2015) Richard Hill et al.   Oncotarget

p53 Functional Inhibitors Behaving Like Pifithrin-β Counteract the Alzheimer Peptide Non-β-amyloid Component Effects in Human SH-SY5Y Cells

(2014) Eleonora Da Pozzo et al.   ACS Chemical Neuroscience

Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

(2014) Ilaria Dutto et al.   ARCHIVES OF TOXICOLOGY

Programmed cell death during neuronal development: the sympathetic neuron model

(2014) M Kristiansen et al.   CELL DEATH AND DIFFERENTIATION

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

CR8, a Novel Inhibitor of CDK, Limits Microglial Activation, Astrocytosis, Neuronal Loss, and Neurologic Dysfunction after Experimental Traumatic Brain Injury

(2014) Shruti V Kabadi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

c-Abl Tyrosine Kinase Mediates Neurotoxic Prion Peptide-Induced Neuronal Apoptosis via Regulating Mitochondrial Homeostasis

(2014) Bo Pan et al.   MOLECULAR NEUROBIOLOGY

Selective CDK inhibitors: promising candidates for future clinical traumatic brain injury trials

(2014) AlanI Faden et al.   Neural Regeneration Research

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

p53 prevents neurodegeneration by regulating synaptic genes

(2014) Paola Merlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SMAR1 coordinates HDAC6-induced deacetylation of Ku70 and dictates cell fate upon irradiation

(2014) N Chaudhary et al.   Cell Death & Disease

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

(2014) Alejandro Álvarez-Quilón et al.   Nature Communications

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

(2014) Piero Dalle Pezze et al.   PLoS Computational Biology

Imatinib treatment and Aβ42 in humans

(2013) Bob Olsson et al.   Alzheimers & Dementia

c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage

(2013) S.M. Nashir Udden et al.   CELLULAR SIGNALLING

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

(2013) Badri Vardarajan et al.   Molecular Neurodegeneration

Physiology: Inflammation links ageing to the brain

(2013) Dana Gabuzda et al.   NATURE

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

p53 in neurodegenerative diseases and brain cancers

(2013) Frédéric Checler et al.   PHARMACOLOGY & THERAPEUTICS

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo

(2013) Oleg Timofeev et al.   Cell Reports

Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress

(2013) Yan Y. Sanders et al.   Redox Biology

Cognitive dysfunction in mitochondrial disorders

(2012) J. Finsterer   ACTA NEUROLOGICA SCANDINAVICA

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors

(2012) Hongen Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The retrograde response: When mitochondrial quality control is not enough

(2012) S. Michal Jazwinski   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Cell Signaling through Protein Kinase C Oxidation and Activation

(2012) Daniela Cosentino-Gomes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ryanodine Receptor Blockade Reduces Amyloid-  Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

(2012) B. Oules et al.   JOURNAL OF NEUROSCIENCE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

A Stochastic Step Model of Replicative Senescence Explains ROS Production Rate in Ageing Cell Populations

(2012) Conor Lawless et al.   PLoS One

Beyond Repair Foci: DNA Double-Strand Break Repair in Euchromatic and Heterochromatic Compartments Analyzed by Transmission Electron Microscopy

(2012) Yvonne Lorat et al.   PLoS One

The DNA Replication Stress Hypothesis of Alzheimer’s Disease

(2012) Yuri B. Yurov et al.   TheScientificWorldJOURNAL

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells

(2012) Yan Li et al.   Chinese Journal of Cancer

Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle

(2011) Iñigo Casafont et al.   ACTA NEUROPATHOLOGICA

A neuroprotective role for the DNA damage checkpoint in tauopathy

(2011) Vikram Khurana et al.   AGING CELL

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

c-Abl in Neurodegenerative Disease

(2011) Sarah D. Schlatterer et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

(2011) Lisa Woodbine et al.   NUCLEIC ACIDS RESEARCH

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

DNA damage, neuronal and glial cell death and neurodegeneration

(2010) Ari Barzilai   APOPTOSIS

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons

(2010) A Tomashevski et al.   CELL DEATH AND DIFFERENTIATION

The checkpoint kinase ATM protects against stress-induced elevation of cyclin D1 and potential cell death in neurons

(2010) Masahiro Hitomi et al.   CYTOMETRY PART A

Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

(2010) Surajit Sinha et al.   EMBO JOURNAL

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

(2010) Ye Xu et al.   JOURNAL OF CELL BIOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

p21 does not protect cancer cells from apoptosis induced by nongenotoxic p53 activation

(2010) M Xia et al.   ONCOGENE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

DNA Damage and Repair in Alzheimers Disease

(2009) Fabio Coppede et al.   Current Alzheimer Research

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

(2009) Ivan Y. Iourov et al.   NEUROBIOLOGY OF DISEASE

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

(2009) Todd E Golde et al.   Alzheimers Research & Therapy

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes

(2008) Richard Hill et al.   DNA REPAIR

p21Cip1 protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways

(2008) P VITIELLO et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid

(2008) Carme Pelegrí et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1

(2008) Nassima Oumata et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

DNA strand breaks, neurodegeneration and aging in the brain

(2008) Sachin Katyal et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint

(2008) Edward Owusu-Ansah et al.   NATURE GENETICS

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation

(2008) Avigail D. Amsel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY