Poly(ADP-ribose) Polymerase-1 in Amyloid Beta Toxicity and Alzheimer's Disease

Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging

(2016) Matthias Altmeyer et al.   Aging-US

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

(2011) Karen Schmitt et al.   ANTIOXIDANTS & REDOX SIGNALING

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β

(2011) Tiina M Kauppinen et al.   Journal of Neuroinflammation

Brain Oligomeric β-Amyloid but Not Total Amyloid Plaque Burden Correlates With Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/Tau Transgenic Mice

(2011) Bibiana DaRocha-Souto et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amyloid  -Induced Impairments in Hippocampal Synaptic Plasticity Are Rescued by Decreasing Mitochondrial Superoxide

(2011) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Poly(ADP-ribose) Polymerase-1 Is a Nuclear Epigenetic Regulator of Mitochondrial DNA Repair and Transcription

(2011) A. Lapucci et al.   MOLECULAR PHARMACOLOGY

Lipoxygenases and Poly(ADP-Ribose) Polymerase in Amyloid Beta Cytotoxicity

(2011) Joanna B. Strosznajder et al.   NEUROCHEMICAL RESEARCH

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

(2011) Jordan T. Newington et al.   PLoS One

Chronic Apocynin Treatment Attenuates Beta Amyloid Plaque Size and Microglial Number in hAPP(751)SL Mice

(2011) Melinda E. Lull et al.   PLoS One

Mitochondrial and Nuclear Cross Talk in Cell Death

(2010) Shaida A. Andrabi et al.   Annals of the New York Academy of Sciences

Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus

(2010) Grzegorz A. Czapski et al.   BRAIN RESEARCH

Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease

(2010) Hsin-Ping Liu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

(2010) Xiaoling Li et al.   JOURNAL OF NEUROCHEMISTRY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function

(2009) Simon Messner et al.   FASEB JOURNAL

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Mitochondrial Localization of PARP-1 Requires Interaction with Mitofilin and Is Involved in the Maintenance of Mitochondrial DNA Integrity

(2009) Marianna N. Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PolyADP-ribosylation is required for long-term memory formation in mammals

(2009) Shmuel Goldberg et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer's disease genetic mutation evokes ultrastructural alterations: Correlation to an intracellular Aβ deposition and the level of GSK-3β-P(Y216) phosphorylated form

(2009) Beata Pajak et al.   NEUROTOXICOLOGY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Zinc Triggers Microglial Activation

(2008) T. M. Kauppinen et al.   JOURNAL OF NEUROSCIENCE

Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells

(2008) Rut Valdor et al.   MOLECULAR IMMUNOLOGY

α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells

(2008) Anna Kazmierczak et al.   NEUROCHEMISTRY INTERNATIONAL

The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases

(2007) Paul et al.   Frontiers in Bioscience-Landmark

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

(2007) S. Lesné et al.   NEUROSCIENCE