Nucleophosmin: from structure and function to disease development

Benefit of high-dose daunorubicin in AML induction extends across cytogenetic and molecular groups

(2016) M. R. Luskin et al.   BLOOD

Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling

(2016) Jingrong Xian et al.   International Journal of Biological Sciences

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer

(2016) Damien Destouches et al.   Oncotarget

1-Benzyl-2-methyl-3-indolylmethylene barbituric acid derivatives: Anti-cancer agents that target nucleophosmin 1 (NPM1)

(2015) Narsimha Reddy Penthala et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells

(2015) M. P. Martelli et al.   BLOOD

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

(2015) H. El Hajj et al.   BLOOD

Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species

(2015) J. S. Garcia et al.   CLINICAL CANCER RESEARCH

Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease

(2015) Jacob G. Jansen et al.   DNA REPAIR

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

(2015) Mattia Poletto et al.   MOLECULAR CARCINOGENESIS

Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency

(2015) M Ceccon et al.   ONCOGENE

NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape

(2015) Karl Holmberg Olausson et al.   Scientific Reports

Expression and Prognostic Significance of APE1/Ref-1 and NPM1 Proteins in High-Grade Ovarian Serous Cancer

(2014) Ambrogio P. Londero et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications

(2014) Mariana Ferreira Leal et al.   BMC GASTROENTEROLOGY

Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling

(2014) Yunxiao Zhou et al.   Cancer Cell International

Insight in the multilevel regulation of NER

(2014) Madelon Dijk et al.   EXPERIMENTAL CELL RESEARCH

Targeting Nucleophosmin 1 Represents a Rational Strategy for Radiation Sensitization

(2014) Konjeti R. Sekhar et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Acute myeloid leukemia in patients older than 75: prognostic impact ofFLT3-ITDandNPM1mutations

(2014) Pierre Hirsch et al.   LEUKEMIA & LYMPHOMA

Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins

(2014) Mattia Poletto et al.   MOLECULAR BIOLOGY OF THE CELL

Extrinsic Apoptosis Is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD

(2014) A. Chattopadhyay et al.   MOLECULAR CANCER RESEARCH

NPM1 Silencing Reduces Tumour Growth and MAPK Signalling in Prostate Cancer Cells

(2014) Gaëlle Loubeau et al.   PLoS One

Structural polymorphism in the N-terminal oligomerization domain of NPM1

(2014) D. M. Mitrea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin

(2014) Omer Ziv et al.   Nature Communications

CD133 and CD133-regulated nucleophosmin linked to 5-fluorouracil susceptibility in human colon cancer cell line SW620

(2013) Kyung-Hee Kim et al.   ELECTROPHORESIS

Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53-mediated cellular senescence

(2013) John C.T. Wong et al.   INTERNATIONAL JOURNAL OF CANCER

Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib

(2013) M Huang et al.   LEUKEMIA

MutatedNPM1in patients with acute myeloid leukemia in remission and relapse

(2013) Preetesh Jain et al.   LEUKEMIA & LYMPHOMA

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Enhanced levels of double-strand DNA break repair proteins protect ovarian cancer cells against genotoxic stress-induced apoptosis

(2013) Rajkumar Kalra et al.   Journal of Ovarian Research

Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis

(2012) Mei-Jiang Zhang et al.   FEBS Journal

Knockdown of NPM1 by RNA Interference Inhibits Cells Proliferation and Induces Apoptosis in Leukemic Cell Line

(2012) Feng-Xian Qin et al.   International Journal of Medical Sciences

Nucleophosmin (NPM1/B23) Interacts with Activating Transcription Factor 5 (ATF5) Protein and Promotes Proteasome- and Caspase-dependent ATF5 Degradation in Hepatocellular Carcinoma Cells

(2012) Xijun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Extensive Tumor Array Analysis Supports Tumor Suppressive Role for Nucleophosmin in Breast Cancer

(2011) Piia-Riitta Karhemo et al.   AMERICAN JOURNAL OF PATHOLOGY

Crystal Structure and Function of Human Nucleoplasmin (Npm2): A Histone Chaperone in Oocytes and Embryos

(2011) Olga Platonova et al.   BIOCHEMISTRY

The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone

(2011) Shrikanth S. Gadad et al.   BIOCHEMISTRY

Nucleophosmin Delocalization in Thyroid Tumour Cells

(2011) Annalisa Pianta et al.   ENDOCRINE PATHOLOGY

Integrative nucleophosmin mutation-associated microRNA and gene expression pattern analysis identifies novel microRNA - target gene interactions in acute myeloid leukemia

(2011) A. C. Russ et al.   HAEMATOLOGICA

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

(2011) George S Vassiliou et al.   NATURE GENETICS

Nucleophosmin is overexpressed in thyroid tumors

(2010) Annalisa Pianta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition

(2010) S. M. Leong et al.   BLOOD

Recruitment of Phosphorylated NPM1 to Sites of DNA Damage through RNF8-Dependent Ubiquitin Conjugates

(2010) A. Koike et al.   CANCER RESEARCH

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nucleophosmin, p53, and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray

(2010) Cláudia Malheiros Coutinho-Camillo et al.   HUMAN PATHOLOGY

Dephosphorylation of Nucleophosmin by PP1β Facilitates pRB Binding and Consequent E2F1-dependent DNA Repair

(2010) Chiao Yun Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

(2009) K. Cheng et al.   BLOOD

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

Nucleophosmin Blocks Mitochondrial Localization of p53 and Apoptosis

(2009) Sanjit Kumar Dhar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GAGE, an Antiapoptotic Protein Binds and Modulates the Expression of Nucleophosmin/B23 and Interferon Regulatory Factor 1

(2009) Rupinder K. Kular et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity

(2009) Y. Perera et al.   MOLECULAR CANCER THERAPEUTICS

RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cells

(2009) Y Jian et al.   ONCOGENE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   BIOCHEMICAL JOURNAL

Lysine 263 residue of NPM/B23 is essential for regulating ATP binding and B23 stability

(2008) Joung Woo Choi et al.   FEBS LETTERS

Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cells

(2008) Mohammed Abdullahel Amin et al.   FEBS LETTERS

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

(2008) Paola Bonetti et al.   JOURNAL OF CELL BIOLOGY

Transcription Regulation of the rRNA Gene by a Multifunctional Nucleolar Protein, B23/Nucleophosmin, through Its Histone Chaperone Activity

(2008) K. Murano et al.   MOLECULAR AND CELLULAR BIOLOGY

NSC348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells

(2008) W Qi et al.   ONCOGENE

Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival

(2008) S. B. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA