Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

Caspase levels and execution efficiencies determine the apoptotic potential of the cell

(2012) Anat Florentin et al.   JOURNAL OF CELL BIOLOGY

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Cleaved caspase-3 expression after experimental stroke exhibits different phenotypes and is predominantly non-apoptotic

(2011) Daniel-Christoph Wagner et al.   BRAIN RESEARCH

Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1

(2011) S. Rumpf et al.   DEVELOPMENT

Mitogenic signaling from apoptotic cells in Drosophila

(2011) Ginés Morata et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain

(2011) Woon Ryoung Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: implications for early detection and therapy

(2011) Vincent T. Marchesi   FASEB JOURNAL

Amyloid β-Mediated Cell Death of Cultured Hippocampal Neurons Reveals Extensive Tau Fragmentation without Increased Full-length Tau Phosphorylation

(2011) Jack Reifert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Live imaging of apoptosis in a novel transgenic mouse highlights its role in neural tube closure

(2011) Yoshifumi Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke

(2011) N. Akpan et al.   JOURNAL OF NEUROSCIENCE

Nonapoptotic Function of BAD and BAX in Long-Term Depression of Synaptic Transmission

(2011) Song Jiao et al.   NEURON

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

(2011) K. T. Al-Jamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

For Synapses, It's Depression Not Death

(2010) Helen S. Bateup et al.   CELL

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

Identification and Evaluation of Small Molecule Pan-Caspase Inhibitors in Huntington's Disease Models

(2010) Melissa J. Leyva et al.   CHEMISTRY & BIOLOGY

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

(2010) D. Halawani et al.   JOURNAL OF NEUROSCIENCE

A Role for the Ubiquitin-Proteasome System in Activity-Dependent Presynaptic Silencing

(2010) X. Jiang et al.   JOURNAL OF NEUROSCIENCE

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Convergence of Amyloid-β and Tau Pathologies on Mitochondria In Vivo

(2010) Anne Eckert et al.   MOLECULAR NEUROBIOLOGY

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

(2010) Marcello D'Amelio et al.   NATURE NEUROSCIENCE

Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration

(2010) Bradley T Hyman   NATURE NEUROSCIENCE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

(2010) F. Cai et al.   NEUROSCIENCE

Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity

(2010) S. Ohsawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

(2009) Junying Yuan   APOPTOSIS

XIAP as a ubiquitin ligase in cellular signaling

(2009) S Galbán et al.   CELL DEATH AND DIFFERENTIATION

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION

The Jekyll and Hyde Functions of Caspases

(2009) Caroline H. Yi et al.   DEVELOPMENTAL CELL

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Tangle-Bearing Neurons Survive Despite Disruption of Membrane Integrity in a Mouse Model of Tauopathy

(2009) Alix de Calignon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Caspase-9 Activation Revealed by Semaphorin 7A Cleavage Is Independent of Apoptosis in the Aged Olfactory Bulb

(2009) S. Ohsawa et al.   JOURNAL OF NEUROSCIENCE

A Retrograde Neuronal Survival Response: Target-Derived Neurotrophins Regulate MEF2D and bcl-w

(2009) M. F. Pazyra-Murphy et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

(2009) Dale E. Bredesen   Molecular Neurodegeneration

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex

(2009) Elaine Leung et al.   NEUROBIOLOGY OF AGING

Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake

(2009) Shaomin Li et al.   NEURON

Regulation of apoptosis by XIAP ubiquitin-ligase activity

(2008) A. J. Schile et al.   GENES & DEVELOPMENT

Developing Postmitotic Mammalian Neurons In Vivo Lacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

(2008) R. W. Oppenheim et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Aβ Plaques Lead to Aberrant Regulation of Calcium Homeostasis In Vivo Resulting in Structural and Functional Disruption of Neuronal Networks

(2008) Kishore V. Kuchibhotla et al.   NEURON