Advanced human developmental toxicity and teratogenicity assessment using human organoid models

Biomaterial-guided stem cell organoid engineering for modeling development and diseases

(2021) Plansky Hoang et al.   Acta Biomaterialia

A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids

(2021) Jong-Chan Park et al.   Nature Communications

Ethanol exposure drives colon location specific cell composition changes in a normal colon crypt 3D organoid model

(2021) Matthew Devall et al.   Scientific Reports

Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure

(2021) Yao Lu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Development of Human Lung Induction Models for Air Pollutants’ Toxicity Assessment

(2021) Shuyu Liu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Clinical Application of Human Induced Pluripotent Stem Cell-Derived Organoids as an Alternative to Organ Transplantation

(2021) Gabriella Shih Ping Hsia et al.   Stem Cells International

Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids

(2021) Sarah S. Wilson et al.   Frontiers in Immunology

The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids

(2021) Yuxiao Zeng et al.   Frontiers in Cell and Developmental Biology

Engineering Vascularized Organoid-on-a-Chip Models

(2021) Venktesh S. Shirure et al.   Annual Review of Biomedical Engineering

Umbilical Cord Blood Metal Mixtures and Birth Size in Bangladeshi Children

(2021) Mi-Sun Lee et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Engineering spatial-organized cardiac organoids for developmental toxicity testing

(2021) Plansky Hoang et al.   Stem Cell Reports

Repopulation of decellularized retinas with hiPSC-derived retinal pigment epithelial and ocular progenitor cells shows cell engraftment, organization and differentiation

(2021) Maria Maqueda et al.   BIOMATERIALS

Cardioids reveal self-organizing principles of human cardiogenesis

(2021) Pablo Hofbauer et al.   CELL

Human brain organoids assemble functionally integrated bilateral optic vesicles

(2021) Elke Gabriel et al.   Cell Stem Cell

Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids

(2021) Galina Popova et al.   Cell Stem Cell

Revealing consensus gene pathways associated with respiratory functions and disrupted by PM2.5 nitrate exposure at bulk tissue and single cell resolution

(2021) Jushan Zhang et al.   ENVIRONMENTAL POLLUTION

Emerging challenges of air pollution and particulate matter in China, India, and Pakistan and mitigating solutions

(2021) Muhammad Naveed Anwar et al.   JOURNAL OF HAZARDOUS MATERIALS

Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids

(2021) Michael Notaras et al.   MOLECULAR PSYCHIATRY

Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

(2021) Sophia K. Longo et al.   NATURE REVIEWS GENETICS

Liver organoid as a 3D in vitro model for drug validation and toxicity assessment

(2021) Anastasia Brooks et al.   PHARMACOLOGICAL RESEARCH

Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment

(2021) Terry Ching et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids

(2021) Ann-Na Cho et al.   Nature Communications

Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter

(2021) Natalie M. Johnson et al.   Environmental Health and Preventive Medicine

Embryo-like models shed fresh light on early human development

(2021) Sandeep Ravindran   NATURE

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

(2021) Veronika Mantziou et al.   REPRODUCTIVE TOXICOLOGY

Exposure to cadmium induces neuroinflammation and impairs ciliogenesis in hESC-derived 3D cerebral organoids

(2021) Yan Huang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure

(2020) Zheng Ao et al.   ANALYTICAL CHEMISTRY

Materials and Microenvironments for Engineering the Intestinal Epithelium

(2020) Jessica Snyder et al.   ANNALS OF BIOMEDICAL ENGINEERING

An organoid-based carcinogenesis model induced by in vitro chemical treatment

(2020) Mie Naruse et al.   CARCINOGENESIS

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessing Toxicity with Human Cell-Based In Vitro Methods

(2020) Daniele Zink et al.   TRENDS IN MOLECULAR MEDICINE

The role of teratogens in neural crest development

(2020) Santiago Cerrizuela et al.   Birth Defects Research

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

(2020) Y Baert et al.   HUMAN REPRODUCTION

SARS-CoV-2 productively infects human gut enterocytes

(2020) Mart M. Lamers et al.   SCIENCE

Black Phosphorus Quantum Dots Cause Nephrotoxicity in Organoids, Mice, and Human Cells

(2020) Chengyong He et al.   Small

Oxidative stress pathways of air pollution mediated toxicity: Recent insights

(2020) Roopesh Singh Gangwar et al.   Redox Biology

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo

(2020) Silvia Velasco et al.   Annual Review of Neuroscience

Adverse effects of nicotine on cardiogenic differentiation from human embryonic stem cells detected by single-cell RNA sequencing

(2020) Biaochuan He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modelling neurodegenerative diseases with 3D brain organoids

(2020) Yujung Chang et al.   BIOLOGICAL REVIEWS

SARS-CoV-2 infects human neural progenitor cells and brain organoids

(2020) Bao-Zhong Zhang et al.   CELL RESEARCH

Cadmium ingestion exacerbates Salmonella infection, with a loss of goblet cells through activation of Notch signaling pathways by ROS in the intestine

(2020) Shuang Xie et al.   JOURNAL OF HAZARDOUS MATERIALS

Toxicity Assessment of SiO2 and TiO2 in Normal Colon Cells, In Vivo and in Human Colon Organoids

(2020) Sung Bum Park et al.   MOLECULES

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

(2020) Battuja Batbajar Dugershaw et al.   Particle and Fibre Toxicology

Single-cell RNA-seq Analysis Reveals That Prenatal Arsenic Exposure Results in Long-term, Adverse Effects on Immune Gene Expression in Response to Influenza A Infection

(2020) Kevin S Hsu et al.   TOXICOLOGICAL SCIENCES

The Influence of Cannabis and Nicotine Co-Use on Neuromaturation – A Systematic Review of Adolescent and Young Adult Studies

(2020) Margie Hernandez Mejia et al.   BIOLOGICAL PSYCHIATRY

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution

(2020) Cameron S. Cowan et al.   CELL

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

(2020) Fadi Jacob et al.   Cell Stem Cell

SARS ‐CoV‐2 targets neurons of 3D human brain organoids

(2020) Anand Ramani et al.   EMBO JOURNAL

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids

(2020) Tadahiro Shinozawa et al.   GASTROENTEROLOGY

Effects of sunset yellow on proliferation and differentiation of intestinal epithelial cells in murine intestinal organoids

(2020) Xiunan Kong et al.   JOURNAL OF APPLIED TOXICOLOGY

Pathological effects of nano-sized particles on the respiratory system

(2020) Richard Nho   Nanomedicine-Nanotechnology Biology and Medicine

Polygenic architecture informs potential vulnerability to drug-induced liver injury

(2020) Masaru Koido et al.   NATURE MEDICINE

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson’s disease

(2020) Ibrahim Boussaad et al.   Science Translational Medicine

COCO enhances the efficiency of photoreceptor precursor differentiation in early human embryonic stem cell-derived retinal organoids

(2020) Deng Pan et al.   Stem Cell Research & Therapy

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

(2020) Thiago Arzua et al.   Translational Psychiatry

Air Quality in Africa: Public Health Implications

(2020) Asmamaw Abera et al.   Annual Review of Public Health

Association between prenatal exposure to persistent organic pollutants and neurodevelopment in early life: A mother-child cohort (Shanghai, China)

(2020) Susu Wang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

(2020) Mart M Lamers et al.   EMBO JOURNAL

The potential toxic effects of magnesium oxide nanoparticles and valproate on liver tissue

(2020) Gehad Mekky et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Breakthrough of ZrO2 nanoparticles into fetal brains depends on developmental stage of maternal placental barrier and fetal blood-brain-barrier

(2020) Zengjin Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

(2020) Yuki Miura et al.   NATURE BIOTECHNOLOGY

Stem-cell-based embryo models for fundamental research and translation

(2020) Jianping Fu et al.   NATURE MATERIALS

Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

(2020) Jochen Kühnl et al.   TOXICOLOGY

An inadvertent issue of human retina exposure to endocrine disrupting chemicals: A safety assessment

(2020) Minghui Li et al.   CHEMOSPHERE

Modeling brain development and diseases with human cerebral organoids

(2020) Yingchao Shi et al.   CURRENT OPINION IN NEUROBIOLOGY

Single-cell RNA sequencing of mouse neural stem cell differentiation reveals adverse effects of cadmium on neurogenesis

(2020) Bo Song et al.   FOOD AND CHEMICAL TOXICOLOGY

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Single-Cell RNA Sequencing of Human Embryonic Stem Cell Differentiation Delineates Adverse Effects of Nicotine on Embryonic Development

(2019) Hongchao Guo et al.   Stem Cell Reports

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

(2019) Gitte Berkers et al.   Cell Reports

Organoid-derived C-Kit+/SSEA4− human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents

(2019) Ting Zou et al.   Nature Communications

Advancing environmental exposure assessment science to benefit society

(2019) Andrew Caplin et al.   Nature Communications

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Early environmental influences on the development of children's brain structure and function

(2019) Patrícia M Miguel et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

(2019) Richard J. Mills et al.   Cell Stem Cell

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Neurotoxicity of pesticides

(2019) Jason R. Richardson et al.   ACTA NEUROPATHOLOGICA

Cell diversity in the human cerebral cortex: from the embryo to brain organoids

(2019) Paola Arlotta et al.   CURRENT OPINION IN NEUROBIOLOGY

Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles

(2019) Na Liu et al.   JOURNAL OF APPLIED TOXICOLOGY

Generation of expandable human pluripotent stem cell-derived hepatocyte-like liver organoids

(2019) Seon Ju Mun et al.   JOURNAL OF HEPATOLOGY

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

(2019) Paulo Emílio Corrêa Leite et al.   Particle and Fibre Toxicology

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity During Neurogenesis

(2019) Hao Chen et al.   TOXICOLOGICAL SCIENCES

Maternal Exposure to Cadmium and Fetal Growth: a Systematic Review and Meta-Analysis

(2019) Mehri Khoshhali et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary

(2019) Hiroyuki Koike et al.   NATURE

Drug-induced liver injury

(2019) Raul J. Andrade et al.   Nature Reviews Disease Primers

Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury

(2019) Shuyong Wang et al.   CELL RESEARCH

Oral administration of hydroxylated-graphene quantum dots induces intestinal injury accompanying the loss of intestinal stem cells and proliferative progenitor cells

(2019) Lan Yu et al.   Nanotoxicology

A rectal cancer organoid platform to study individual responses to chemoradiation

(2019) Karuna Ganesh et al.   NATURE MEDICINE

Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids

(2019) Darin Zerti et al.   STEM CELLS

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

(2019) Swagata Ghatak et al.   eLife

Stem cell-derived kidney organoids: engineering the vasculature

(2019) Marije Koning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mesoderm specification and diversification: from single cells to emergent tissues

(2019) Elisabetta Ferretti et al.   CURRENT OPINION IN CELL BIOLOGY

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

(2018) Stefan M. Czerniecki et al.   Cell Stem Cell

Predictors of thallium exposure and its relation with preterm birth

(2018) Yangqian Jiang et al.   ENVIRONMENTAL POLLUTION

PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

(2018) Bian-Rong Wang et al.   Journal of Neuroinflammation

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

(2018) David Pamies et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells

(2018) Silvia Parisi et al.   Scientific Reports

In Vitro Induction and In Vivo Engraftment of Lung Bud Tip Progenitor Cells Derived from Human Pluripotent Stem Cells

(2018) Alyssa J. Miller et al.   Stem Cell Reports

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

(2018) Sandro Nuciforo et al.   Cell Reports

Vincristine Impairs Microtubules and Causes Neurotoxicity in Cerebral Organoids

(2018) Fangkun Liu et al.   NEUROSCIENCE

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

(2018) Lorna J. Hale et al.   Nature Communications

Association of Prenatal Exposure to Air Pollution With Autism Spectrum Disorder

(2018) Lief Pagalan et al.   JAMA Pediatrics

The association between PM2.5 exposure and neurological disorders: A systematic review and meta-analysis

(2018) Pengfei Fu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Probing impaired neurogenesis in human brain organoids exposed to alcohol

(2017) Yujuan Zhu et al.   Integrative Biology

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Uroplakin 3a + Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair

(2017) Arjun Guha et al.   Cell Reports

Tranylcypromine Causes Neurotoxicity and Represses BHC110/LSD1 in Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids Model

(2017) Jing Huang et al.   Frontiers in Neurology

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells

(2017) Karl J. Wahlin et al.   Scientific Reports

The Driving Mechanism for Unidirectional Blood Flow in the Tubular Embryonic Heart

(2016) Pavel Kozlovsky et al.   ANNALS OF BIOMEDICAL ENGINEERING

A Novel Model of P-Glycoprotein Inhibitor Screening Using Human Small Intestinal Organoids

(2016) Junfang Zhao et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Stem Cell Models of Human Brain Development

(2016) Iva Kelava et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery

(2016) Vaibhav Shinde et al.   CURRENT MEDICINAL CHEMISTRY

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

(2016) Aleksander Skardal et al.   DRUG DISCOVERY TODAY

Prenatal exposure to persistent organic pollutants in association with offspring neuropsychological development at 4years of age: The Rhea mother-child cohort, Crete, Greece

(2016) Andriani Kyriklaki et al.   ENVIRONMENT INTERNATIONAL

Maternal urinary cadmium concentrations in relation to preterm birth in the Healthy Baby Cohort Study in China

(2016) Jie Yang et al.   ENVIRONMENT INTERNATIONAL

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Generation of kidney organoids from human pluripotent stem cells

(2016) Minoru Takasato et al.   Nature Protocols

Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals

(2016) Katherine E. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Effects of Polyamidoamine Dendrimers on a 3-D Neurosphere System Using Human Neural Progenitor Cells

(2016) Yang Zeng et al.   TOXICOLOGICAL SCIENCES

Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing

(2016) J. Sandström Von Tobel et al.   TOXICOLOGY LETTERS

Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes

(2016) Agnes Maillet et al.   Scientific Reports

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

The ethics of stem cells revisited

(2015) Iñigo de Miguel-Beriain   ADVANCED DRUG DELIVERY REVIEWS

Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study

(2015) Jiu-Chiuan Chen et al.   ANNALS OF NEUROLOGY

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

The acute respiratory exposure by intratracheal instillation of Sprague–Dawley rats with diesel particulate matter induces retinal thickening

(2015) Sungjin Kim et al.   Cutaneous and Ocular Toxicology

Long-term PM2.5 Exposure and Neurological Hospital Admissions in the Northeastern United States

(2015) Marianthi-Anna Kioumourtzoglou et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Rise of Stem Cell Toxicology

(2015) Francesco Faiola et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Three dimensional spheroid cell culture for nanoparticle safety testing

(2015) Franziska Sambale et al.   JOURNAL OF BIOTECHNOLOGY

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

(2015) Fotios Sampaziotis et al.   NATURE BIOTECHNOLOGY

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Developmental Exposure to Environmental Toxicants

(2015) Alison J. Falck et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Air Pollution and Stillbirth Risk: Exposure to Airborne Particulate Matter during Pregnancy Is Associated with Fetal Death

(2015) Emily DeFranco et al.   PLoS One

Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure

(2015) Esther L. Calderon-Gierszal et al.   PLoS One

Smoking and increased Alzheimer's disease risk: A review of potential mechanisms

(2014) Timothy C. Durazzo et al.   Alzheimers & Dementia

Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model

(2014) Anna I. Astashkina et al.   BIOMATERIALS

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

Detection of Thalidomide Embryotoxicity by In Vitro Embryotoxicity Testing Based on Human iPS Cells

(2014) Nobuo Aikawa et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

An in vivo model of human small intestine using pluripotent stem cells

(2014) Carey L Watson et al.   NATURE MEDICINE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo

(2014) Esther de Jong et al.   REPRODUCTIVE TOXICOLOGY

Biomimicry 3D Gastrointestinal Spheroid Platform for the Assessment of Toxicity and Inflammatory Effects of Zinc Oxide Nanoparticles

(2014) Sing Ling Chia et al.   Small

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Bisphenol A affects androgen receptor function via multiple mechanisms

(2013) Christina Teng et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Stem Cell Models for Drug Discovery and Toxicology Studies

(2013) Wenwei Liu et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Nanoparticles Do Not Penetrate Human Skin—A Theoretical Perspective

(2013) Adam C. Watkinson et al.   PHARMACEUTICAL RESEARCH

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental stage dependent neural stem cells sensitivity to methylmercury chloride on different biofunctional surfaces

(2013) M. Zychowicz et al.   TOXICOLOGY IN VITRO

Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking

(2012) Timothy C. Durazzo et al.   Alzheimers & Dementia

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

(2012) Lisa Hoelting et al.   ARCHIVES OF TOXICOLOGY

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Toxicology of nanoparticles

(2011) Andreas Elsaesser et al.   ADVANCED DRUG DELIVERY REVIEWS

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents

(2011) Junyi Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Embryotoxicity assessment of developmental neurotoxicants using a neuronal endpoint in the embryonic stem cell test

(2011) Dae Hyun Baek et al.   JOURNAL OF APPLIED TOXICOLOGY

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

Nanotoxicology—A Pathologist’s Perspective

(2011) Ann F. Hubbs et al.   TOXICOLOGIC PATHOLOGY

Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes

(2011) Liang Guo et al.   TOXICOLOGICAL SCIENCES

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations

(2011) J.D. Cohen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The effect of TiO2 and Ag nanoparticles on reproduction and development of Drosophila melanogaster and CD-1 mice

(2011) Nicola A. Philbrook et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Induced pluripotent stem cells: paths to new medicines

(2010) Wenbin Deng   EMBO REPORTS

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(2010) Larry L. Needham et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

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(2010) Hak Soo Choi et al.   NATURE BIOTECHNOLOGY

Prenatal Alcohol Exposure and Neurodevelopmental Disorders in Children Adopted From Eastern Europe

(2010) M. Landgren et al.   PEDIATRICS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse

(2009) Midori Shimizu et al.   Particle and Fibre Toxicology

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(2009) Michelle L. Block et al.   TRENDS IN NEUROSCIENCES

Nanotechnology in Medical Imaging

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Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell

The effects of heavy metals on embryonic development of fish (a review)

(2008) Barbara Jezierska et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY