A cellular census of human lungs identifies novel cell states in health and in asthma

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

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A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

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Allergic inflammatory memory in human respiratory epithelial progenitor cells

(2018) Jose Ordovas-Montanes et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

The Lung in Primary Immunodeficiencies: New Concepts in Infection and Inflammation

(2018) Ulrich Baumann et al.   Frontiers in Immunology

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Pathogenic CD4 + T cells in patients with asthma

(2017) Lyndsey M. Muehling et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Trigger-happy resident memory CD4+ T cells inhabit the human lungs

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Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

A phenotypically and functionally distinct human T H 2 cell subpopulation is associated with allergic disorders

(2017) Erik Wambre et al.   Science Translational Medicine

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD

(2017) J. Song et al.   Clinical Epigenetics

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases

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IL-25/IL-33–responsive T H 2 cells characterize nasal polyps with a default T H 17 signature in nasal mucosa

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Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

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Protein S is protective in pulmonary fibrosis

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FXYD1 negatively regulates Na+/K+-ATPase activity in lung alveolar epithelial cells

(2016) Łukasz A. Wujak et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

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Asthma is not only an airway disease, but also a vascular disease

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Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung

(2015) Henry Danahay et al.   Cell Reports

Asthma

(2015) Stephen T. Holgate et al.   Nature Reviews Disease Primers

Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway

(2015) Kazunori Gomi et al.   PLoS One

Mitotic Asynchrony Induces Transforming Growth Factor-β1 Secretion from Airway Epithelium

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Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The cell biology of asthma

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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

Decoding asthma: Translating genetic variation in IL33 and IL1RL1 into disease pathophysiology

(2013) Néomi S. Grotenboer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

STAR: ultrafast universal RNA-seq aligner

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Airway epithelial cells from asthmatic children differentially express proremodeling factors

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Lung dendritic cells at the innate-adaptive immune interface

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Prostaglandin D2and TH2 Inflammation in the Pathogenesis of Bronchial Asthma

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Mast Cell Phenotype, Location, and Activation in Severe Asthma

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Thymic Stromal Lymphopoietin Gene Promoter Polymorphisms Are Associated with Susceptibility to Bronchial Asthma

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Fast and SNP-tolerant detection of complex variants and splicing in short reads

(2010) T. D. Wu et al.   BIOINFORMATICS

Bronchial epithelial cells produce IL-5: Implications for local immune responses in the airways

(2010) Carol A. Wu et al.   CELLULAR IMMUNOLOGY

Accumulation of intraepithelial mast cells with a unique protease phenotype in TH2-high asthma

(2010) Ryan H. Dougherty et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Synaptotagmin-mediated vesicle fusion regulates cell migration

(2010) Richard A Colvin et al.   NATURE IMMUNOLOGY

Haplotypes covering the TNFSF10 gene are associated with bronchial asthma

(2010) Markus Weckmann et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

LILRA5 is expressed by synovial tissue macrophages in rheumatoid arthritis, selectively induces pro-inflammatory cytokines and IL-10 and is regulated by TNF-α, IL-10 and IFN-γ

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