Optimized Culture Conditions for Improved Growth and Functional Differentiation of Mouse and Human Colon Organoids

L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams

(2019) Kelli L. VanDussen et al.   Stem Cell Research

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

(2019) Rachel Freire et al.   Scientific Reports

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types

(2018) Benjamin E. Mead et al.   BMC BIOLOGY

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Immunology of Food Allergy

(2017) Leticia Tordesillas et al.   IMMUNITY

The mucosal barrier at a glance

(2017) Marion M. France et al.   JOURNAL OF CELL SCIENCE

Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer

(2017) Jos P.M. van Putten et al.   Journal of Innate Immunity

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

Scaling single-cell genomics from phenomenology to mechanism

(2017) Amos Tanay et al.   NATURE

Environmental triggers in IBD: a review of progress and evidence

(2017) Ashwin N. Ananthakrishnan et al.   Nature Reviews Gastroenterology & Hepatology

Mechanisms of Cell Polarity–Controlled Epithelial Homeostasis and Immunity in the Intestine

(2017) Leon J. Klunder et al.   Cold Spring Harbor Perspectives in Biology

The Human Cell Atlas

(2017) Aviv Regev et al.   eLife

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

The global burden of IBD: from 2015 to 2025

(2015) Gilaad G. Kaplan   Nature Reviews Gastroenterology & Hepatology

Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays

(2014) Kelli L VanDussen et al.   GUT

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

A small intestinal organoid model of non-invasive enteric pathogen–epithelial cell interactions

(2014) S S Wilson et al.   Mucosal Immunology

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

(2013) Hiroyuki Miyoshi et al.   Nature Protocols

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Intestinal epithelial cells in inflammatory bowel diseases

(2010) Giulia Roda   WORLD JOURNAL OF GASTROENTEROLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE