Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles

(2020) Sarah Logan et al.   Cells

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(2019) Yan-Peng Xu et al.   CELL RESEARCH

FOXP2 exhibits neuron class specific expression, but is not required for multiple aspects of cortical histogenesis

(2019) Ryan J Kast et al.   eLife

Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons

(2019) Martina Donadoni et al.   Cell Death & Disease

KCNC1 ‐related disorders: new de novo variants expand the phenotypic spectrum

(2019) Joohyun Park et al.   Annals of Clinical and Translational Neurology

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes

(2019) Yuichi Horikoshi et al.   Cells

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Cortical Foxp2 Supports Behavioral Flexibility and Developmental Dopamine D1 Receptor Expression

(2019) Marissa Co et al.   CEREBRAL CORTEX

Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities

(2018) Philip A. May et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders

(2018) Friederike Ehrhart et al.   MOLECULAR PSYCHIATRY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Animal models of binge drinking, current challenges to improve face validity

(2018) Jérôme Jeanblanc et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

(2018) Priya Srikanth et al.   Translational Psychiatry

Mitochondrial Chaperones in the Brain: Safeguarding Brain Health and Metabolism?

(2018) José Pedro Castro et al.   Frontiers in Endocrinology

Propofol Alters Long Non-Coding RNA Profiles in the Neonatal Mouse Hippocampus: Implication of Novel Mechanisms in Anesthetic-Induced Developmental Neurotoxicity

(2018) Sarah Logan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC–Derived Neural 3D Cultures

(2018) Oksana Sirenko et al.   TOXICOLOGICAL SCIENCES

Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice

(2018) Yongchao Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Prenatal alcohol use as a risk for attention-deficit/hyperactivity disorder

(2018) Daniel Pagnin et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Brain Organoids and the Study of Neurodevelopment

(2018) Cleber A. Trujillo et al.   TRENDS IN MOLECULAR MEDICINE

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Perceptions of Fetal Alcohol Spectrum Disorder (FASD) at a Mental Health Outpatient Treatment Provider in Minnesota

(2018) Jerrod Brown et al.   International Journal of Environmental Research and Public Health

Probing impaired neurogenesis in human brain organoids exposed to alcohol

(2017) Yujuan Zhu et al.   Integrative Biology

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Neural Progenitor Cell Polarity and Cortical Development

(2017) Yoko Arai et al.   Frontiers in Cellular Neuroscience

Derivation of Functional Human Astrocytes from Cerebral Organoids

(2017) Rômulo Sperduto Dezonne et al.   Scientific Reports

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth

(2017) Shannon Lange et al.   JAMA Pediatrics

Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1

(2017) E. K. Stachowiak et al.   Translational Psychiatry

Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility

(2017) Abiola A. Ayanlaja et al.   Frontiers in Molecular Neuroscience

An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment

(2016) Keshav K. Gupta et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity

(2016) Zeljko J. Bosnjak et al.   ANESTHESIA AND ANALGESIA

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Hippocampal hyperexcitability in fetal alcohol spectrum disorder: Pathological sharp waves and excitatory/inhibitory synaptic imbalance

(2016) Michal Krawczyk et al.   EXPERIMENTAL NEUROLOGY

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Cellular and molecular introduction to brain development

(2016) Xiangning Jiang et al.   NEUROBIOLOGY OF DISEASE

Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus

(2016) K.E. Boschen et al.   NEUROSCIENCE

Declines in Unintended Pregnancy in the United States, 2008–2011

(2016) Lawrence B. Finer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Apoptotic Cell Death and Temporal Expression of Apoptotic Proteins Bcl-2 and Bax in the Hippocampus, Following Binge Ethanol in the Neonatal Rat Model

(2015) Caine C. Smith et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Altered Mitochondrial Dynamics Contributes to Propofol-induced Cell Death in Human Stem Cell–derived Neurons

(2015) Danielle M. Twaroski et al.   ANESTHESIOLOGY

Up-regulation of MicroRNA-21 Mediates Isoflurane-induced Protection of Cardiomyocytes

(2015) Jessica M. Olson et al.   ANESTHESIOLOGY

Generating Neuronal Diversity in the Mammalian Cerebral Cortex

(2015) Simona Lodato et al.   Annual Review of Cell and Developmental Biology

The Flaws and Human Harms of Animal Experimentation

(2015) AYSHA AKHTAR   CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Comparison of Cardiomyocyte Differentiation Potential between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells

(2015) Chika Kikuchi et al.   CELL TRANSPLANTATION

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Misdiagnosis and Missed Diagnoses in Foster and Adopted Children With Prenatal Alcohol Exposure

(2015) I. J. Chasnoff et al.   PEDIATRICS

Fetal Alcohol Spectrum Disorders

(2015) J. F. Williams et al.   PEDIATRICS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol use and binge drinking among women of childbearing age — United States, 2011–2013

(2015) Cheryl H. Tan et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Prenatal Ethanol Exposure Impairs Executive Function in Mice into Adulthood

(2015) Kristin Marquardt et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Ethanol Upregulates NMDA Receptor Subunit Gene Expression in Human Embryonic Stem Cell-Derived Cortical Neurons

(2015) Yangfei Xiang et al.   PLoS One

Effects of one- and three-day binge alcohol exposure in neonatal C57BL/6 mice on spatial learning and memory in adolescence and adulthood

(2014) Jennifer L. Wagner et al.   ALCOHOL

Down-regulation of MicroRNA-21 Is Involved in the Propofol-induced Neurotoxicity Observed in Human Stem Cell–derived Neurons

(2014) Danielle M. Twaroski et al.   ANESTHESIOLOGY

The Bioenergetic Health Index: a new concept in mitochondrial translational research

(2014) Balu K. Chacko et al.   CLINICAL SCIENCE

Prenatal exposure to binge pattern of alcohol consumption: mental health and learning outcomes at age 11

(2014) Kapil Sayal et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Modulation of learning and memory by cytokines: Signaling mechanisms and long term consequences

(2014) Elissa J. Donzis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Ketamine Enhances Human Neural Stem Cell Proliferation and Induces Neuronal Apoptosis via Reactive Oxygen Species–Mediated Mitochondrial Pathway

(2013) Xiaowen Bai et al.   ANESTHESIA AND ANALGESIA

FoxP2 Regulates Neurogenesis during Embryonic Cortical Development

(2013) D. Tsui et al.   JOURNAL OF NEUROSCIENCE

Immature Doublecortin-Positive Hippocampal Neurons Are Important for Learning But Not for Remembering

(2013) J. Vukovic et al.   JOURNAL OF NEUROSCIENCE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Novel Oxytocin Gene Expression in the Hindbrain Is Induced by Alcohol Exposure: Transgenic Zebrafish Enable Visualization of Sensitive Neurons

(2013) Caitrín M. Coffey et al.   PLoS One

Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1α

(2013) Anne R. Diers et al.   PLoS One

Evidence that Doublecortin Is Dispensable for the Development of Adult Born Neurons in Mice

(2013) Katharina Merz et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain

(2013) Catherine E Creeley et al.   Acta Neuropathologica Communications

Marked Hyperglycemia Attenuates Anesthetic Preconditioning in Human-induced Pluripotent Stem Cell-derived Cardiomyocytes

(2012) Scott G. Canfield et al.   ANESTHESIOLOGY

Integration of cellular bioenergetics with mitochondrial quality control and autophagy

(2012) Bradford G. Hill et al.   BIOLOGICAL CHEMISTRY

Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons

(2012) Dimitrios E. Kouzoukas et al.   JOURNAL OF NEUROCHEMISTRY

Properties of Doublecortin Expressing Neurons in the Adult Mouse Dentate Gyrus

(2012) Jay Spampanato et al.   PLoS One

What Do We Know about the Economic Impact of Fetal Alcohol Spectrum Disorder? A Systematic Literature Review

(2011) Svetlana Popova et al.   ALCOHOL AND ALCOHOLISM

Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain

(2011) Silvia Alfonso-Loeches et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Fetal Alcohol Spectrum Disorders: An Overview

(2011) Edward P. Riley et al.   NEUROPSYCHOLOGY REVIEW

Fetal Alcohol Spectrum Disorders: Gene-Environment Interactions, Predictive Biomarkers, and the Relationship Between Structural Alterations in the Brain and Functional Outcomes

(2011) James N. Reynolds et al.   Seminars in Pediatric Neurology

Prenatal Alcohol Exposure Induces Long-Term Changes in Dendritic Spines and Synapses in the Mouse Visual Cortex

(2010) Z.-J. Cui et al.   ALCOHOL AND ALCOHOLISM

Ethanol Alters Cell Fate of Fetal Human Brain-Derived Stem and Progenitor Cells

(2010) Sharada D. Vangipuram et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Alcohol-induced neuroapoptosis in the fetal macaque brain

(2010) Nuri B. Farber et al.   NEUROBIOLOGY OF DISEASE

The Basics of Brain Development

(2010) Joan Stiles et al.   NEUROPSYCHOLOGY REVIEW

The Probable Role of Tumor Stem Cells for Lymph Node Metastasis in Supraglottic Carcinoma

(2010) Sumei Lu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Neural Differentiation from Human Embryonic Stem Cells as a Tool to Study Early Brain Development and the Neuroteratogenic Effects of Ethanol

(2010) Raquel Taléns-Visconti et al.   STEM CELLS AND DEVELOPMENT

Psychiatric conditions associated with prenatal alcohol exposure

(2009) Mary J. O'Connor et al.   Developmental Disabilities Research Reviews

Alcohol Related Changes in Regulation of NMDA Receptor Functions

(2008) Jozsef Nagy   Current Neuropharmacology

Mitochondrial Dysfunction and Psychiatric Disorders

(2008) Gislaine T. Rezin et al.   NEUROCHEMICAL RESEARCH

Concise Review: Pax6 Transcription Factor Contributes to both Embryonic and Adult Neurogenesis as a Multifunctional Regulator

(2008) Noriko Osumi et al.   STEM CELLS