In vitro teratogenicity testing using a 3D, embryo-like gastruloid system

Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4

(2020) David G. Belair et al.   Scientific Reports

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Pluripotent stem cell models of early mammalian development

(2020) Peter Baillie-Benson et al.   CURRENT OPINION IN CELL BIOLOGY

Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

(2020) Manuela Jaklin et al.   REPRODUCTIVE TOXICOLOGY

Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells

(2019) Yusuke Marikawa et al.   REPRODUCTIVE TOXICOLOGY

Determinants of free serum valproate concentration: A prospective study in patients on divalproex sodium monotherapy

(2018) Wassim Nasreddine et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Teratogen screening with human pluripotent stem cells

(2018) Kathryn E. Worley et al.   Integrative Biology

Self-organization of a human organizer by combined Wnt and Nodal signalling

(2018) I. Martyn et al.   NATURE

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

(2018) Mary E. Matyskiela et al.   Nature Chemical Biology

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

(2018) Katherine A Donovan et al.   eLife

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

A human induced pluripotent stem cell-based in vitro assay predicts developmental toxicity through a retinoic acid receptor-mediated pathway for a series of related retinoid analogues

(2017) Jessica A. Palmer et al.   REPRODUCTIVE TOXICOLOGY

Alternative Models of Developmental and Reproductive Toxicity in Pharmaceutical Risk Assessment and the 3Rs

(2016) Kimberly C. Brannen et al.   ILAR JOURNAL

Exposure-Based Validation List for Developmental Toxicity Screening Assays

(2014) George P. Daston et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse embryonic stem cells

(2014) S. C. van den Brink et al.   DEVELOPMENT

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods

(2014) Sheppard A. Martin et al.   TOXICOLOGICAL SCIENCES

Sox2, a key factor in the regulation of pluripotency and neural differentiation

(2014) Shuchen Zhang   World Journal of Stem Cells

A High-Throughput Screen for Teratogens Using Human Pluripotent Stem Cells

(2013) Sei Kameoka et al.   TOXICOLOGICAL SCIENCES

The validated embryonic stem cell test to predict embryotoxicity in vitro

(2011) Andrea E M Seiler et al.   Nature Protocols

Differences between the Measured and Calculated Free Serum Phenytoin Concentrations in Epileptic Patients

(2009) Ji-Man Hong et al.   YONSEI MEDICAL JOURNAL

Assessment of drug induced developmental toxicity using human embryonic stem cells

(2008) A MEHTA et al.   CELL BIOLOGY INTERNATIONAL