Cardioids reveal self-organizing principles of human cardiogenesis

Characterization of a common progenitor pool of the epicardium and myocardium

(2021) Richard C. V. Tyser et al.   SCIENCE

Cardiac Fibroblast Diversity

(2020) Michelle D. Tallquist   Annual Review of Physiology

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

(2020) Elisa Giacomelli et al.   Cell Stem Cell

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling Pathways

(2020) Alessio Strano et al.   Cell Reports

Capturing Cardiogenesis in Gastruloids

(2020) Giuliana Rossi et al.   Cell Stem Cell

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

(2019) Xuran Wang et al.   Nature Communications

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

(2019) Yueli Cui et al.   Cell Reports

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Dual lineage tracing identifies intermediate mesenchymal stage for endocardial contribution to fibroblasts, coronary mural cells and adipocytes

(2019) Xinyan Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis

(2019) Tui Neri et al.   Nature Communications

Fluorescent Gene Tagging of Transcriptionally Silent Genes in hiPSCs

(2019) Brock Roberts et al.   Stem Cell Reports

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects

(2019) T. Yvanka de Soysa et al.   NATURE

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

Human Organoids: Tools for Understanding Biology and Treating Diseases

(2019) Frans Schutgens et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanotransduction in cardiovascular morphogenesis and tissue engineering

(2019) Anne-Laure Duchemin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Kidney organoids: accurate models or fortunate accidents

(2019) Melissa H. Little et al.   GENES & DEVELOPMENT

Laminins in Cellular Differentiation

(2019) Lynn Yap et al.   TRENDS IN CELL BIOLOGY

Genetic Basis of Human Congenital Heart Disease

(2019) Shannon N. Nees et al.   Cold Spring Harbor Perspectives in Biology

In Vivo and In Vitro Genetic Models of Congenital Heart Disease

(2019) Uddalak Majumdar et al.   Cold Spring Harbor Perspectives in Biology

Genetic Fate Mapping Defines the Vascular Potential of Endocardial Cells in the Adult HeartNovelty and Significance

(2018) Juan Tang et al.   CIRCULATION RESEARCH

The ontogeny, activation and function of the epicardium during heart development and regeneration

(2018) Filipa C. Simões et al.   DEVELOPMENT

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

The epicardium as a hub for heart regeneration

(2018) Jingli Cao et al.   Nature Reviews Cardiology

Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq

(2018) Fabienne Lescroart et al.   SCIENCE

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network

(2018) David J. Anderson et al.   Nature Communications

The deployment of cell lineages that form the mammalian heart

(2018) Sigolène M. Meilhac et al.   Nature Reviews Cardiology

Body Cavity Development Is Guided by Morphogen Transfer between Germ Layers

(2018) Jan Schlueter et al.   Cell Reports

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

(2017) Richard J. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

(2017) Joshua W. Vincentz et al.   PLoS Genetics

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

(2017) Juan Antonio Guadix et al.   Stem Cell Reports

Genetics of Cardiac Developmental Disorders: Cardiomyocyte Proliferation and Growth and Relevance to Heart Failure

(2016) Lisa Wilsbacher et al.   Annual Review of Pathology-Mechanisms of Disease

The developmental origins and lineage contributions of endocardial endothelium

(2016) Atsushi Nakano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

(2016) Timm Haack et al.   DEVELOPMENT

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

(2016) Nathan J Palpant et al.   Nature Protocols

Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell LossCLINICAL PERSPECTIVE

(2015) Anthony C. Sturzu et al.   CIRCULATION

Functional Recovery of a Human Neonatal Heart After Severe Myocardial InfarctionNovelty and Significance

(2015) Bernhard J. Haubner et al.   CIRCULATION RESEARCH

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

(2015) H. D. Devalla et al.   EMBO Molecular Medicine

Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells

(2015) Matthew J Birket et al.   NATURE BIOTECHNOLOGY

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

(2015) Christoph Patsch et al.   NATURE CELL BIOLOGY

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

(2015) Nathaniel Huebsch et al.   TISSUE ENGINEERING PART C-METHODS

Self-organizing human cardiac microchambers mediated by geometric confinement

(2015) Zhen Ma et al.   Nature Communications

NANOG and CDX2 Pattern Distinct Subtypes of Human Mesoderm during Exit from Pluripotency

(2014) Sasha Mendjan et al.   Cell Stem Cell

Developmental Heterogeneity of Cardiac Fibroblasts Does Not Predict Pathological Proliferation and Activation

(2014) Shah R. Ali et al.   CIRCULATION RESEARCH

Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis

(2014) Thomas Moore-Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Generation of the epicardial lineage from human pluripotent stem cells

(2014) Alec D Witty et al.   NATURE BIOTECHNOLOGY

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells

(2014) Valeria V Orlova et al.   Nature Protocols

Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome

(2014) Junko Kobayashi et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Heart Fields and Cardiac Morphogenesis

(2014) R. G. Kelly et al.   Cold Spring Harbor Perspectives in Medicine

A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration

(2013) Sarah E. Mercer et al.   DEVELOPMENTAL BIOLOGY

Cytosystems dynamics in self-organization of tissue architecture

(2013) Yoshiki Sasai   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

(2013) Mei Xin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Genetic engineering of human pluripotent cells using TALE nucleases

(2011) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

(2011) Ita Costello et al.   NATURE CELL BIOLOGY

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Nkx2–5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo

(2009) Anwarul Ferdous et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compensatory Growth of Healthy Cardiac Cells in the Presence of Diseased Cells Restores Tissue Homeostasis during Heart Development

(2008) Jörg-Detlef Drenckhahn et al.   DEVELOPMENTAL CELL

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population

(2008) Lei Yang et al.   NATURE