Characterization of application scenario-dependent pharmacokinetics and pharmacodynamic properties of permethrin and hyperforin in a dynamic skin and liver multi-organ-chip model

Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics‐relevant chemicals

(2020) Joan Eilstein et al.   JOURNAL OF APPLIED TOXICOLOGY

Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility

(2018) Kerstin Reisinger et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes

(2018) Laura Hedges et al.   XENOBIOTICA

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

(2018) Juliane Hübner et al.   Scientific Reports

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

(2017) Christian Maass et al.   Integrative Biology

In vitro human skin permeation of benzene in gasoline: Effects of concentration, multiple dosing and skin preparation

(2017) H Frederick Frasch et al.   Journal of Exposure Science and Environmental Epidemiology

From the Cover: Three-Dimensional (3D) HepaRG Spheroid Model With Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening

(2017) Sreenivasa C. Ramaiahgari et al.   TOXICOLOGICAL SCIENCES

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Emulating human microcapillaries in a multi-organ-chip platform

(2015) Tobias Hasenberg et al.   JOURNAL OF BIOTECHNOLOGY

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

(2015) Sarah Gordon   ALTEX-Alternatives to Animal Experimentation

HepaRG culture in tethered spheroids as anin vitrothree-dimensional model for drug safety screening

(2014) Zenan Wang et al.   JOURNAL OF APPLIED TOXICOLOGY

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses

(2014) K. E. Chapman et al.   MUTAGENESIS

Effect of Skin Metabolism on Dermal Delivery of Testosterone: Qualitative Assessment using a New Short-Term Skin Model

(2014) C. Jacques et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Evaluation of the stereoselective biotransformation of permethrin in human liver microsomes: Contributions of cytochrome P450 monooxygenases to the formation of estrogenic metabolites

(2014) Ramon Lavado et al.   TOXICOLOGY LETTERS

Do partition coefficients (liphophilicity/hydrophilicity) predict effects of occlusion on percutaneous penetrationin vitro: a retrospective review

(2013) Farhaan Hafeez et al.   Cutaneous and Ocular Toxicology

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

(2013) Beren Ataç et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Occlusion Effect on in vivo Percutaneous Penetration of Chemicals in Man and Monkey: Partition Coefficient Effects

(2013) Farhaan Hafeez et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

(2013) Nicola J. Hewitt et al.   TOXICOLOGICAL SCIENCES

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes

(2013) M.J.A. Jetten et al.   TOXICOLOGY IN VITRO

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

(2012) Li Di et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

Estimation of the Percutaneous Absorption of Permethrin in Humans Using the Parallelogram Method

(2011) John H. Ross et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models

(2011) Christine Götz et al.   XENOBIOTICA

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes

(2010) Juho Hokkanen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pyrethroids: Mammalian Metabolism and Toxicity

(2010) Hideo Kaneko   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

The Phenion® Full-Thickness Skin Model for Percutaneous Absorption Testing

(2009) K. Ackermann et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates

(2007) Jaesung Park et al.   BIOTECHNOLOGY AND BIOENGINEERING