A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

Formation of organotypic testicular organoids in microwell culture†

(2019) Sadman Sakib et al.   BIOLOGY OF REPRODUCTION

Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury

(2019) Yitian Zhou et al.   Frontiers in Pharmacology

Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures

(2018) Yuichi Yokoyama et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Basic and Clinical Approaches for Fertility Preservation and Restoration in Cancer Patients

(2018) Jose V Medrano et al.   TRENDS IN BIOTECHNOLOGY

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Testicular organoids: a new model to study the testicular microenvironment in vitro?

(2017) João Pedro Alves-Lopes et al.   HUMAN REPRODUCTION UPDATE

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

The impact of drugs on male fertility: a review

(2017) M. Semet et al.   Andrology

Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties

(2017) Yoni Baert et al.   Stem Cell Reports

Pumpless microfluidic system driven by hydrostatic pressure induces and maintains mouse spermatogenesis in vitro

(2017) Mitsuru Komeya et al.   Scientific Reports

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications

(2016) Leonard J. Nelson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents

(2016) Emad Ghobadi et al.   Expert Opinion on Drug Metabolism & Toxicology

The epidemiologic evidence linking prenatal and postnatal exposure to endocrine disrupting chemicals with male reproductive disorders: a systematic review and meta-analysis

(2016) Jens Peter Bonde et al.   HUMAN REPRODUCTION UPDATE

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device

(2016) Mitsuru Komeya et al.   Scientific Reports

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

(2016) J. S. Gabrielsen et al.   Andrology

The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs

(2015) Yue Jia et al.   APOPTOSIS

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model

(2015) Sander van den Driesche et al.   Science Translational Medicine

Persistent organic pollutants and male reproductive health

(2014) Anne Vested et al.   ASIAN JOURNAL OF ANDROLOGY

Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors

(2014) René Habert et al.   REPRODUCTION

Performance of Comet and Micronucleus Assays in Metabolic Competent HepaRG Cells to Predict In Vivo Genotoxicity

(2014) Ludovic Le Hégarat et al.   TOXICOLOGICAL SCIENCES

In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

(2014) Louise Parks Saldutti   ALTEX-Alternatives to Animal Experimentation

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

What is the best cryopreservation protocol for human testicular tissue banking?

(2013) Y. Baert et al.   HUMAN REPRODUCTION

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Assuring safety without animal testing: The case for the human testis in vitro

(2013) Robert E. Chapin et al.   REPRODUCTIVE TOXICOLOGY

Alternatives to animal testing: current status and future perspectives

(2011) Manfred Liebsch et al.   ARCHIVES OF TOXICOLOGY

Testicular function and fertility preservation in male cancer patients

(2011) Kirsi Jahnukainen et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

miRNA and mammalian male germ cells

(2011) S.C. McIver et al.   HUMAN REPRODUCTION UPDATE

In vitro production of functional sperm in cultured neonatal mouse testes

(2011) Takuya Sato et al.   NATURE

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Childhood Acute Lymphoblastic Leukemia Therapy on Spermatogonia Populations and Future Fertility

(2009) Mirja Nurmio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM