Targeting immune dysfunction in aging

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

(2021) Paras S. Minhas et al.   NATURE

B Cells with a Senescent-Associated Secretory Phenotype Accumulate in the Adipose Tissue of Individuals with Obesity

(2021) Daniela Frasca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans

(2021) Ricardo I. Martínez‐Zamudio et al.   AGING CELL

Age‐related changes to macrophages are detrimental to fracture healing in mice

(2020) Daniel Clark et al.   AGING CELL

Age-Associated B Cells

(2020) Michael P. Cancro   Annual Review of Immunology

CAR T cells: continuation in a revolution of immunotherapy

(2020) Anurag K Singh et al.   LANCET ONCOLOGY

Personal aging markers and ageotypes revealed by deep longitudinal profiling

(2020) Sara Ahadi et al.   NATURE MEDICINE

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

(2020) Rachel Thomas et al.   Immunity & Ageing

The road ahead for health and lifespan interventions

(2020) Marta Gonzalez-Freire et al.   AGEING RESEARCH REVIEWS

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

(2020) Yusheng Cai et al.   CELL RESEARCH

Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly

(2020) Roel P. H. De Maeyer et al.   NATURE IMMUNOLOGY

Sestrins induce natural killer function in senescent-like CD8+ T cells

(2020) Branca I. Pereira et al.   NATURE IMMUNOLOGY

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice

(2020) Shota Yoshida et al.   Nature Communications

Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

(2020) Marisa Stebegg et al.   eLife

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

(2020) Maria Carolina Florian et al.   AGING CELL

T cells, aging and senescence

(2020) Luca Pangrazzi et al.   EXPERIMENTAL GERONTOLOGY

Senolytic drugs: from discovery to translation

(2020) J. L. Kirkland et al.   JOURNAL OF INTERNAL MEDICINE

Estimates of the severity of coronavirus disease 2019: a model-based analysis

(2020) Robert Verity et al.   LANCET INFECTIOUS DISEASES

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

(2020) Yuchi Honaker et al.   Science Translational Medicine

The interplay between immunosenescence and age-related diseases

(2020) Florencia Barbé-Tuana et al.   Seminars in Immunopathology

Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response

(2020) Lucas Leite Cunha et al.   Frontiers in Immunology

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblast (FREF) to counteract age-related inflammation

(2020) Jiyoung Oh et al.   JCI Insight

SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime

(2020) Renato Domingues et al.   Aging-US

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

DCAF1 regulates Treg senescence via the ROS axis during immunological aging

(2020) Zengli Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

(2020) Sara Campinoti et al.   Nature Communications

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

(2019) Adriaan A. van Beek et al.   TRENDS IN IMMUNOLOGY

Hallmarks of Aging: An Autophagic Perspective

(2019) María Carolina Barbosa et al.   Frontiers in Endocrinology

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

(2019) Ayelet Alpert et al.   NATURE MEDICINE

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

(2019) Frank Madeo et al.   Cell Metabolism

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

(2019) Matthew Simon et al.   Cell Metabolism

Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells

(2019) Arne Søraas et al.   AGING CELL

Depletion of B cells rejuvenates the peripheral B‐cell compartment but is insufficient to restore immune competence in aging

(2019) Irit Avivi et al.   AGING CELL

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

(2019) Takahiro Kamiya et al.   JOURNAL OF CLINICAL INVESTIGATION

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

Influence of Resveratrol on the Immune Response

(2019) Malaguarnera   Nutrients

Therapeutic Regeneration of Lymphatic and Immune Cell Functions upon Lympho-organoid Transplantation

(2019) Elisa Lenti et al.   Stem Cell Reports

Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice

(2019) Marina V. Kovina et al.   Frontiers in Genetics

Gene editing for immune cell therapies

(2019) Stefanie R. Bailey et al.   NATURE BIOTECHNOLOGY

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

(2019) Branca I. Pereira et al.   Nature Communications

Human natural killer cells mediate adaptive immunity to viral antigens

(2019) Rana Nikzad et al.   Science Immunology

Reversal of epigenetic aging and immunosenescent trends in humans

(2019) Gregory M. Fahy et al.   AGING CELL

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

(2019) Anna Aiello et al.   Frontiers in Immunology

Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes

(2019) Yehezqel Elyahu et al.   Science Advances

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Rapamycin for longevity: opinion article

(2019) Mikhail V. Blagosklonny   Aging-US

Age‐related alterations in human gut CD4 T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria

(2019) Stephanie M. Dillon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence

(2019) Hanlin Zhang et al.   MOLECULAR CELL

Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis

(2019) John D. Coakley et al.   PLoS One

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

(2019) Christina D. Camell et al.   Cell Metabolism

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8 + T cells

(2019) Luca Pangrazzi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The timeline of epigenetic drug discovery: from reality to dreams

(2019) A. Ganesan et al.   Clinical Epigenetics

Elevated levels of the small GTPase Cdc42 induces senescence in male rat mesenchymal stem cells

(2018) Bauyrzhan Umbayev et al.   BIOGERONTOLOGY

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

(2018) Hanna Leins et al.   BLOOD

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

(2018) Luis Rajman et al.   Cell Metabolism

Lymphoid tissue fibrosis is associated with impaired vaccine responses

(2018) Cissy Kityo et al.   JOURNAL OF CLINICAL INVESTIGATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

(2018) Steve Horvath et al.   NATURE REVIEWS GENETICS

Thymic involution and rising disease incidence with age

(2018) Sam Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetic control of stemness in CD8+T cell fate commitment

(2018) Luigia Pace et al.   SCIENCE

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor

(2018) Diana Chaker et al.   Stem Cell Research & Therapy

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Age-Related Decline in Primary CD8 + T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8 + T Cells

(2018) Kylie M. Quinn et al.   Cell Reports

Abnormal Epigenetic Regulation of Immune System during Aging

(2018) Miriam G. Jasiulionis   Frontiers in Immunology

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

Epigenetic Maintenance of Acquired Gene Expression Programs during Memory CD8 T Cell Homeostasis

(2018) Hossam A. Abdelsamed et al.   Frontiers in Immunology

Rational identification of a Cdc42 inhibitor presents a new regimen for long-term hematopoietic stem cell mobilization

(2018) Wei Liu et al.   LEUKEMIA

Aging alters the epigenetic asymmetry of HSC division

(2018) M. Carolina Florian et al.   PLOS BIOLOGY

Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing

(2018) Francesco Prattichizzo et al.   AGEING RESEARCH REVIEWS

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

(2018) Heather L. Thompson et al.   AGING CELL

Epigenomic drivers of immune dysfunction in aging

(2018) Christine R. Keenan et al.   AGING CELL

Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians

(2018) Enzo Tedone et al.   AGING CELL

Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells

(2018) Pascale André et al.   CELL

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

(2018) Adriaan A. van Beek et al.   Immunity & Ageing

Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors

(2017) Kengo Yoshida et al.   EXPERIMENTAL GERONTOLOGY

Autoimmunity in the Elderly: Insights from Basic Science and Clinics - A Mini-Review

(2017) Abdulla Watad et al.   GERONTOLOGY

Telomere-driven diseases and telomere-targeting therapies

(2017) Paula Martínez et al.   JOURNAL OF CELL BIOLOGY

The chromatin accessibility signature of human immune aging stems from CD8+T cells

(2017) Duygu Ucar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Chromatin Accessibility Programs CD8 T Cell Memory

(2017) Christopher D. Scharer et al.   JOURNAL OF IMMUNOLOGY

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

(2017) Kentaro Hosokawa et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Interleukin-7 and Immunosenescence

(2017) Vanloan Nguyen et al.   Journal of Immunology Research

Calorie Restriction Attenuates Terminal Differentiation of Immune Cells

(2017) Matthew J. White et al.   Frontiers in Immunology

Biological Age Predictors

(2017) Juulia Jylhävä et al.   EBioMedicine

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

(2016) Sudhanshu Agrawal et al.   Aging-US

Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans

(2016) Simin N. Meydani et al.   Aging-US

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia

(2016) C. Bar et al.   BLOOD

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

FOXN1 in thymus organogenesis and development

(2016) Harsh Jayesh Vaidya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Obesity accelerates T cell senescence in murine visceral adipose tissue

(2016) Kohsuke Shirakawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

(2016) Haiyoung Jung et al.   Nature Communications

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

(2016) Dounia Djeghloul et al.   Stem Cell Reports

Convergence of Innate and Adaptive Immunity during Human Aging

(2016) Branca I. Pereira et al.   Frontiers in Immunology

ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients

(2015) O. Trédan et al.   ANNALS OF ONCOLOGY

B cells in the aging immune system: time to consider B-1 cells

(2015) Nichol E. Holodick et al.   Annals of the New York Academy of Sciences

Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses

(2015) Mi-Jeong Kim et al.   JOURNAL OF IMMUNOLOGY

Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus

(2015) Immanuel Rode et al.   JOURNAL OF IMMUNOLOGY

Cell Therapy Strategies to Combat Immunosenescence

(2015) Elizabeth C Stahl et al.   Organogenesis

Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis

(2015) Sathish Babu Vasamsetti et al.   DIABETES

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

(2015) Chan C. Whiting et al.   PLoS One

Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres

(2014) J. Wang et al.   BLOOD

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

(2014) Nicholas Bredenkamp et al.   NATURE CELL BIOLOGY

mTOR inhibition improves immune function in the elderly

(2014) J. B. Mannick et al.   Science Translational Medicine

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice

(2013) Connie Jackaman et al.   AGING CELL

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding

(2013) E. Verovskaya et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

DNA methylation analysis of murine hematopoietic side population cells during aging

(2013) Oluwatosin Taiwo et al.   Epigenetics

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

(2013) Maria Carolina Florian et al.   NATURE

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Human regulatory T cells induce T-lymphocyte senescence

(2012) J. Ye et al.   BLOOD

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

NK Cells in Healthy Aging and Age-Associated Diseases

(2012) Xavier Camous et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

(2012) Rhys S. Allan et al.   NATURE

Review: Microglia of the aged brain: primed to be activated and resistant to regulation

(2012) D. M. Norden et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling

(2012) S. Rajagopalan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell maintenance and function in aging

(2012) Igor Kogut et al.   SEMINARS IN IMMUNOLOGY

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

(2011) Z. Keren et al.   BLOOD

Age-related changes in natural killer cell receptors from childhood through old age

(2011) Aline Almeida-Oliveira et al.   HUMAN IMMUNOLOGY

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunosenescence of Human Natural Killer Cells

(2011) Inmaculada Gayoso et al.   Journal of Innate Immunity

Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells

(2011) Jonathan Sprent et al.   NATURE IMMUNOLOGY

Natural killer cell memory

(2011) Silke Paust et al.   NATURE IMMUNOLOGY

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

(2011) Claudia E. Rübe et al.   PLoS One

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution

(2010) Liguang Sun et al.   AGING CELL

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

Older Adults Have a Low Capacity To Opsonize Pneumococci Due to Low IgM Antibody Response to Pneumococcal Vaccinations

(2010) Saeyoung Park et al.   INFECTION AND IMMUNITY

Dendritic cells: Bridging innate and adaptive immunity in atopic dermatitis

(2010) Natalija Novak et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

(2009) Janelle S. Ayres et al.   PLOS BIOLOGY

Exogenous insulin-like growth factor 1 enhances thymopoiesis predominantly through thymic epithelial cell expansion

(2008) Y.-W. Chu et al.   BLOOD

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY