A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

(2018) Etienne Patin et al.   NATURE IMMUNOLOGY

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy

(2017) Jana Blazkova et al.   JOURNAL OF IMMUNOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diffusion pseudotime robustly reconstructs lineage branching

(2016) Laleh Haghverdi et al.   NATURE METHODS

Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

(2016) Yun Lin et al.   Immunity & Ageing

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

Utilizing population variation, vaccination, and systems biology to study human immunology

(2015) John S. Tsang   TRENDS IN IMMUNOLOGY

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Immune aging, dysmetabolism, and inflammation in neurological diseases

(2015) Michela Deleidi et al.   Frontiers in Neuroscience

A modified generalized Fisher method for combining probabilities from dependent tests

(2014) Hongying Dai et al.   Frontiers in Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Variability in the immune system: of vaccine responses and immune states

(2013) Shai S Shen-Orr et al.   CURRENT OPINION IN IMMUNOLOGY

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner

(2013) Behdad Afzali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Frailty in elderly people

(2013) Andrew Clegg et al.   LANCET

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

(2013) D. Furman et al.   Molecular Systems Biology

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

(2013) D. Furman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Influenza vaccine responses in older adults

(2010) Janet E. McElhaney   AGEING RESEARCH REVIEWS

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE