B cells in the aging immune system: time to consider B-1 cells

Age-related immune response to pneumococcal polysaccharide vaccination: lessons for the clinic

(2014) Anita S Iyer et al.   Expert Review of Vaccines

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

B-1a Cell Diversity: Nontemplated Addition in B-1a Cell Ig Is Determined by Progenitor Population and Developmental Location

(2014) N. E. Holodick et al.   JOURNAL OF IMMUNOLOGY

Splenic B-1a Cells Expressing CD138 Spontaneously Secrete Large Amounts of Immunoglobulin in Naïve Mice

(2014) Nichol E. Holodick et al.   Frontiers in Immunology

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Human B-1 cells take the stage

(2013) Thomas L. Rothstein et al.   Annals of the New York Academy of Sciences

A comparative review of aging and B cell function in mice and humans

(2013) Jean L Scholz et al.   CURRENT OPINION IN IMMUNOLOGY

Impaired B lymphopoiesis in old age: a role for inflammatory B cells?

(2013) Richard L. Riley   IMMUNOLOGIC RESEARCH

Aging and neoteny in the B lineage

(2012) D. Melamed et al.   BLOOD

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential

(2012) T. Shimazu et al.   BLOOD

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

(2012) A. V. Ergen et al.   BLOOD

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells

(2012) E. E. B. Ghosn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-modulation by polyclonal IgM treatment reduces atherosclerosis in hypercholesterolemic apoE−/− mice

(2011) Fernando H.Y. Cesena et al.   ATHEROSCLEROSIS

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

(2011) Z. Keren et al.   BLOOD

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

(2011) Tin Kyaw et al.   CIRCULATION RESEARCH

Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

(2011) S. Z. Birjandi et al.   JOURNAL OF IMMUNOLOGY

Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential

(2011) M. Yoshimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells

(2011) C. L. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age

(2010) Chloé Lescale et al.   AGING CELL

The effect of age on the response to the pneumococcal polysaccharide vaccine

(2010) Hyunju Lee et al.   BMC INFECTIOUS DISEASES

Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells

(2010) Nichol E. Holodick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

E proteins and the regulation of early lymphocyte development

(2010) Renée F. De Pooter et al.   IMMUNOLOGICAL REVIEWS

Induction of B-cell development in adult mice reveals the ability of bone marrow to produce B-1a cells

(2009) S. Duber et al.   BLOOD

Immunoglobulin M Is Required for Protection Against Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

(2009) Myles J. Lewis et al.   CIRCULATION

Adult BM generates CD5+ B1 cells containing abundant N-region additions

(2009) Nichol E. Holodick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Migration of immature and mature B cells in the aged microenvironment

(2009) Heather A. Minges Wols et al.   IMMUNOLOGY

Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage

(2009) Sarah Alter-Wolf et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A differentiation pathway for B1 cells in adult bone marrow

(2009) B. L. Esplin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune therapy for age-related diseases

(2009) Marc E. Weksler et al.   TRENDS IN IMMUNOLOGY

The role of B lymphocytes as antigen-presenting cells

(2008) Xinjian Chen et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis

(2008) C. T. Jensen et al.   BLOOD