Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Authors
Keywords
-
Journal
Science Advances
Volume 5, Issue 8, Pages eaaw8330
Publisher
American Association for the Advancement of Science (AAAS)
Online
2019-08-22
DOI
10.1126/sciadv.aaw8330
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
- (2019) Ilias Angelidis et al. Nature Communications
- A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
- (2019) Ayelet Alpert et al. NATURE MEDICINE
- Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging
- (2018) Peggie Cheung et al. CELL
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR
- (2018) David Zemmour et al. NATURE IMMUNOLOGY
- Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
- (2018) Xinyi Guo et al. NATURE MEDICINE
- Induction and transcriptional regulation of the co-inhibitory gene module in T cells
- (2018) Norio Chihara et al. NATURE
- The translation of non-canonical open reading frames controls mucosal immunity
- (2018) Ruaidhrí Jackson et al. NATURE
- Successful and Maladaptive T Cell Aging
- (2017) Jörg J. Goronzy et al. IMMUNITY
- Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
- (2017) David Furman et al. NATURE MEDICINE
- SCENIC: single-cell regulatory network inference and clustering
- (2017) Sara Aibar et al. NATURE METHODS
- Aging increases cell-to-cell transcriptional variability upon immune stimulation
- (2017) Celia Pilar Martinez-Jimenez et al. SCIENCE
- Making Mouse Models That Reflect Human Immune Responses
- (2017) Lili Tao et al. TRENDS IN IMMUNOLOGY
- Massively parallel digital transcriptional profiling of single cells
- (2017) Grace X. Y. Zheng et al. Nature Communications
- Old Mice Accumulate Activated Effector CD4 T Cells Refractory to Regulatory T Cell-Induced Immunosuppression
- (2017) Idan Harpaz et al. Frontiers in Immunology
- Regulatory T cells in cancer immunotherapy
- (2016) Atsushi Tanaka et al. CELL RESEARCH
- The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses
- (2016) Lindsay K. Ward-Kavanagh et al. IMMUNITY
- Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids
- (2016) Shuji Hibiya et al. Journal of Crohns & Colitis
- The cellular composition of the human immune system is shaped by age and cohabitation
- (2016) Edward J Carr et al. NATURE IMMUNOLOGY
- Senescence of T Lymphocytes: Implications for Enhancing Human Immunity
- (2016) Arne N. Akbar et al. TRENDS IN IMMUNOLOGY
- The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
- (2015) Gustavo J. Martinez et al. IMMUNITY
- The Importance of Cooperation: Partnerless NFAT Induces T Cell Exhaustion
- (2015) Bertram Bengsch et al. IMMUNITY
- Identification of Glial Activation Markers by Comparison of Transcriptome Changes between Astrocytes and Microglia following Innate Immune Stimulation
- (2015) Silvia Madeddu et al. PLoS One
- IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
- (2015) Hirotake Tsukamoto et al. Nature Communications
- NFATc1 Regulates PD-1 Expression upon T Cell Activation
- (2014) K. J. Oestreich et al. JOURNAL OF IMMUNOLOGY
- Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories
- (2014) Janko Nikolich-Žugich JOURNAL OF IMMUNOLOGY
- Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
- (2014) C. Franceschi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Cellular senescence: from physiology to pathology
- (2014) Daniel Muñoz-Espín et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
- (2014) Diana Jurk et al. Nature Communications
- Metabolic Regulation of T Lymphocytes
- (2013) Nancie J. MacIver et al. Annual Review of Immunology
- Transcriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II–restricted cytotoxic T lymphocytes
- (2013) Daniel Mucida et al. NATURE IMMUNOLOGY
- CD4+ T Cell-Receptor Repertoire Diversity is Compromised in the Spleen but Not in the Bone Marrow of Aged Mice Due to Private and Sporadic Clonal Expansions
- (2013) Eric Shifrut et al. Frontiers in Immunology
- When aging reaches CD4+ T-cells: phenotypic and functional changes
- (2013) Marco Antonio Moro-García Frontiers in Immunology
- Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
- (2012) Guangjin Li et al. NATURE MEDICINE
- The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
- (2011) Erika Cretney et al. NATURE IMMUNOLOGY
- Differentiation of Effector CD4 T Cell Populations
- (2010) Jinfang Zhu et al. Annual Review of Immunology
- Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
- (2010) Sergio A. Quezada et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural insights into the assembly and activation of IL-1β with its receptors
- (2010) Dongli Wang et al. NATURE IMMUNOLOGY
- Age-associated parallel increase of Foxp3+CD4+ regulatory and CD44+CD4+ memory T cells in SJL/J mice
- (2009) Guang-Ming Han et al. CELLULAR IMMUNOLOGY
- Effects of aging on T cell function
- (2009) Laura Haynes et al. CURRENT OPINION IN IMMUNOLOGY
- Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
- (2009) H. Tsukamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Essential role for Bclaf1 in lung development and immune system function
- (2008) J Peter McPherson et al. CELL DEATH AND DIFFERENTIATION
- T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
- (2008) Xuexian O. Yang et al. IMMUNITY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now