mTOR inhibition improves immune function in the elderly

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

(2014) Mitchell Barns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NFATc1 Regulates PD-1 Expression upon T Cell Activation

(2014) K. J. Oestreich et al.   JOURNAL OF IMMUNOLOGY

Late-life rapamycin treatment reverses age-related heart dysfunction

(2013) James M. Flynn et al.   AGING CELL

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses

(2013) F. Spensieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preserving Youth: Does Rapamycin Deliver?

(2013) S. C. Johnson et al.   Science Translational Medicine

The Gracefully Aging Immune System

(2013) D. Boraschi et al.   Science Translational Medicine

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Viral acute lower respiratory infections impair CD8+ T cells through PD-1

(2012) John J. Erickson et al.   JOURNAL OF CLINICAL INVESTIGATION

Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway

(2010) Celine S. Lages et al.   AGING CELL

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

(2010) I. R. Ferrer et al.   JOURNAL OF IMMUNOLOGY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

PD-1+ memory phenotype CD4+ T cells expressing C/EBP  underlie T cell immunodepression in senescence and leukemia

(2009) K. Shimatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data

(2008) Chiaki Tanaka et al.   JOURNAL OF CLINICAL ONCOLOGY