Convergence of Innate and Adaptive Immunity during Human Aging

Aberrant NKG2D expression with IL-17 production of CD4+ T subsets in patients with type 2 diabetes

(2017) Wisitsak Phoksawat et al.   IMMUNOBIOLOGY

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells

(2016) Saïda Dadi et al.   CELL

Interleukin-15-Dependent T-Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease

(2016) Julien Ettersperger et al.   IMMUNITY

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5′-Monophosphate–Activated Protein Kinase

(2016) Bojana Müller-Durovic et al.   JOURNAL OF IMMUNOLOGY

Parallels and differences between innate and adaptive lymphocytes

(2016) Sammy Bedoui et al.   NATURE IMMUNOLOGY

T Cells Going Innate

(2016) Midas Seyda et al.   TRENDS IN IMMUNOLOGY

NKG2D expression by CD8+ T cells contributes to GVHD and GVT effects in a murine model of allogeneic HSCT

(2015) M. A. Karimi et al.   BLOOD

The dual-functional capability of cytokine-induced killer cells and application in tumor immunology

(2015) Qiang Zhang et al.   HUMAN IMMUNOLOGY

The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection

(2015) Claudia X. Dominguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anatomy of a murder: how cytotoxic T cells and NK cells are activated, develop, and eliminate their targets

(2015) Judy Lieberman   IMMUNOLOGICAL REVIEWS

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of CD56 and TCR-Independent Activation of T Cells with Aging

(2014) B. H. Lemster et al.   JOURNAL OF IMMUNOLOGY

Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells

(2014) A. van Stijn et al.   JOURNAL OF IMMUNOLOGY

Coordinated Regulation of NK Receptor Expression in the Maturing Human Immune System

(2014) Dara M. Strauss-Albee et al.   JOURNAL OF IMMUNOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Ontogeny of Innate T Lymphocytes – Some Innate Lymphocytes are More Innate than Others

(2014) David Vermijlen et al.   Frontiers in Immunology

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

(2013) Melanie Wencker et al.   NATURE IMMUNOLOGY

Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation

(2013) J Adam Best et al.   NATURE IMMUNOLOGY

Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

(2013) Talyn Chu et al.   Cell Reports

T Cell Aging: A Review of the Transcriptional Changes Determined from Genome-Wide Analysis

(2013) Guobing Chen et al.   Frontiers in Immunology

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Properties of end-stage human T cells defined by CD45RA re-expression

(2012) Sian M Henson et al.   CURRENT OPINION IN IMMUNOLOGY

Inflammatory Monocytes Activate Memory CD8+ T and Innate NK Lymphocytes Independent of Cognate Antigen during Microbial Pathogen Invasion

(2012) Saïdi M'Homa Soudja et al.   IMMUNITY

Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation

(2012) Xiaohua Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

(2012) Guangjin Li et al.   NATURE MEDICINE

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

(2012) Jörg J. Goronzy et al.   SEMINARS IN IMMUNOLOGY

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

The unmet need in the elderly: How immunosenescence, CMV infection, co-morbidities and frailty are a challenge for the development of more effective influenza vaccines

(2012) Janet E. McElhaney et al.   VACCINE

NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system

(2011) Rebeca Alonso-Arias et al.   AGE

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity

(2011) A. Pievani et al.   BLOOD

Bridging Innate and Adaptive Immunity

(2011) William E. Paul   CELL

Development of PLZF-expressing innate T cells

(2011) Eric S Alonzo et al.   CURRENT OPINION IN IMMUNOLOGY

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+ CD45RA+ CD27− T cells: the potential involvement of interleukin-7 in this process

(2011) Valentina Libri et al.   IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses

(2011) R. Lachmann et al.   JOURNAL OF VIROLOGY

An NKG2D-Mediated Human Lymphoid Stress Surveillance Response with High Interindividual Variation

(2011) S. Shafi et al.   Science Translational Medicine

Blockade of NKG2D Synergized With CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Cardiac Transplantation

(2011) Jun Li et al.   TRANSPLANTATION

Expansions of NK-like αβT cells with chronologic aging: Novel lymphocyte effectors that compensate for functional deficits of conventional NK cells and T cells

(2010) Abbe N. Vallejo et al.   AGEING RESEARCH REVIEWS

Impact of age on T cell signaling: A general defect or specific alterations?

(2010) Anis Larbi et al.   AGEING RESEARCH REVIEWS

Age-related alterations of gene expression patterns in human CD8+ T cells

(2010) Jia-Ning Cao et al.   AGING CELL

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC)

(2010) C. Hontscha et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

T Cell-Intrinsic Factors Contribute to the Differential Ability of CD8+ T Cells To Rapidly Secrete IFN-  in the Absence of Antigen

(2010) E. N. Bou Ghanem et al.   JOURNAL OF IMMUNOLOGY

PLZF Induces the Spontaneous Acquisition of Memory/Effector Functions in T Cells Independently of NKT Cell-Related Signals

(2010) D. Kovalovsky et al.   JOURNAL OF IMMUNOLOGY

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Cytokine-induced killer cells are terminallydifferentiated activated CD8 cytotoxic T-EMRA lymphocytes

(2009) Marta Franceschetti et al.   EXPERIMENTAL HEMATOLOGY

Loss of the LAT Adaptor Converts Antigen-Responsive T Cells into Pathogenic Effectors that Function Independently of the T Cell Receptor

(2009) Michael Mingueneau et al.   IMMUNITY

Transcriptional Repressor Blimp-1 Promotes CD8+ T Cell Terminal Differentiation and Represses the Acquisition of Central Memory T Cell Properties

(2009) Rachel L. Rutishauser et al.   IMMUNITY

Blimp-1 Transcription Factor Is Required for the Differentiation of Effector CD8+ T Cells and Memory Responses

(2009) Axel Kallies et al.   IMMUNITY

Adaptive immune features of natural killer cells

(2009) Joseph C. Sun et al.   NATURE

Thymic involution and immune reconstitution

(2009) Heather E. Lynch et al.   TRENDS IN IMMUNOLOGY

CD28− T cells: their role in the age-associated decline of immune function

(2009) Nan-ping Weng et al.   TRENDS IN IMMUNOLOGY

Microarray analysis reveals similarity between CD8+CD28− T cells from young and elderly persons, but not of CD8+CD28+ T cells

(2008) Lutfan Lazuardi et al.   BIOGERONTOLOGY

Tumor-derived soluble MICs impair CD3+CD56+ NKT-like cell cytotoxicity in cancer patients

(2008) H WANG et al.   IMMUNOLOGY LETTERS

Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis

(2008) Jessica Strid et al.   NATURE IMMUNOLOGY

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

(2008) Damian Kovalovsky et al.   NATURE IMMUNOLOGY

The immune system in extreme longevity

(2007) P. Sansoni et al.   EXPERIMENTAL GERONTOLOGY