ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients

Sequential immune monitoring in patients with melanoma and renal cell carcinoma treated with high-dose interleukin-2: immune patterns and correlation with outcome

(2014) David M. Foureau et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Chemo-Immunotherapy with Oxaliplatin and Interleukin-7 Inhibits Colon Cancer Metastasis in Mice

(2014) Hong-Feng Gou et al.   PLoS One

Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection

(2014) Rodolphe Thiébaut et al.   PLoS Computational Biology

IL-7 Modulates In Vitro and In Vivo Human Memory T Regulatory Cell Functions through the CD39/ATP Axis

(2013) M. Younas et al.   JOURNAL OF IMMUNOLOGY

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

(2012) M.-A. Perales et al.   BLOOD

ICOS-Ligand Expression on Plasmacytoid Dendritic Cells Supports Breast Cancer Progression by Promoting the Accumulation of Immunosuppressive CD4+ T Cells

(2012) J. Faget et al.   CANCER RESEARCH

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Effects of Recombinant Human Interleukin 7 on T-Cell Recovery and Thymic Output in HIV-Infected Patients Receiving Antiretroviral Therapy: Results of a Phase I/IIa Randomized, Placebo-Controlled, Multicenter Study

(2012) Y. Lévy et al.   CLINICAL INFECTIOUS DISEASES

CD4 lymphopenia to identify end-of-life metastatic cancer patients

(2012) Julien Péron et al.   EUROPEAN JOURNAL OF CANCER

Patients with metastatic breast cancer leading to CD4+ T cell lymphopaenia have poor outcome

(2012) Olivier Trédan et al.   EUROPEAN JOURNAL OF CANCER

Lymphopenia is an Independent Predictor of Inferior Outcome in Clear Cell Renal Carcinoma

(2012) Sunil Saroha et al.   JOURNAL OF UROLOGY

Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival

(2012) Michel Morre et al.   Targeted Oncology

Targeting regulatory T cells

(2012) Christine Ménétrier-Caux et al.   Targeted Oncology

Lymphopenia combined with low TCR diversity (divpenia) predicts poor overall survival in metastatic breast cancer patients

(2012) Manuarii Manuel et al.   OncoImmunology

Pre-treatment lymphopenia as a prognostic biomarker in colorectal cancer patients receiving chemotherapy

(2011) N. Cézé et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Endothelial Nitric Oxide Synthase Is a Key Mediator of Interleukin-2-Induced Hypotension and Vascular Leak Syndrome

(2011) Wolfram E. Samlowski et al.   JOURNAL OF IMMUNOTHERAPY

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells

(2010) Federico Simonetta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques

(2009) S. Beq et al.   BLOOD

Regulatory T Cells Recruited through CCL22/CCR4 Are Selectively Activated in Lymphoid Infiltrates Surrounding Primary Breast Tumors and Lead to an Adverse Clinical Outcome

(2009) M. Gobert et al.   CANCER RESEARCH

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE