Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Convalescent plasma as a potential therapy for COVID-19

(2020) Long Chen et al.   LANCET INFECTIOUS DISEASES

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

COVID-19 infection: the perspectives on immune responses

(2020) Yufang Shi et al.   CELL DEATH AND DIFFERENTIATION

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

(2020) Meijuan Zheng et al.   Cellular & Molecular Immunology

Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients

(2020) Hong-Yi Zheng et al.   Cellular & Molecular Immunology

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

(2020) Ling Ni et al.   IMMUNITY

Immunology of COVID-19: current state of the science

(2020) Nicolas Vabret et al.   IMMUNITY

Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

(2020) Chenguang Shen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis

(2020) Francisco Alejandro Lagunas-Rangel   JOURNAL OF MEDICAL VIROLOGY

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19

(2020) Irani Thevarajan et al.   NATURE MEDICINE

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

Neutralizing Antibodies against SARS-CoV-2 and Other Human Coronaviruses

(2020) Shibo Jiang et al.   TRENDS IN IMMUNOLOGY

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

(2020) Wen Wen et al.   Cell Discovery

Lymphopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A systemic review and meta-analysis

(2020) Qianwen Zhao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Comprehensive mapping of immune perturbations associated with severe COVID-19

(2020) Leticia Kuri-Cervantes et al.   Science Immunology

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types

(2018) Allison R. Greenplate et al.   Cancer Immunology Research

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

(2017) Alexander C. Huang et al.   NATURE

Earth Mover’s Distance (EMD): A True Metric for Comparing Biomarker Expression Levels in Cell Populations

(2016) Darya Y. Orlova et al.   PLoS One

Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection

(2016) C Agrati et al.   Cell Death & Disease

FlowSOM: Using self-organizing maps for visualization and interpretation of cytometry data

(2015) Sofie Van Gassen et al.   CYTOMETRY PART A

Magnitude and Kinetics of CD8 + T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

(2015) Zaza M. Ndhlovu et al.   IMMUNITY

Human Ebola virus infection results in substantial immune activation

(2015) Anita K. McElroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

(2015) Prakash K. Gupta et al.   PLoS Pathogens

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans

(2012) J. Wrammert et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Circulating Human Antibody-Secreting Cells during Vaccinations and Respiratory Viral Infections Are Characterized by High Specificity and Lack of Bystander Effect

(2011) F. E.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans

(2009) G. Blanchard-Rohner et al.   BLOOD

Human Effector and Memory CD8+ T Cell Responses to Smallpox and Yellow Fever Vaccines

(2008) Joseph D. Miller et al.   IMMUNITY