mTOR is a key modulator of ageing and age-related disease

Metformin for aging and cancer prevention

(2016) Vladimir N. Anisimov   Aging-US

Autophagy is required for extension of yeast chronological life span by rapamycin

(2014) Ashley L. Alvers et al.   Autophagy

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Preventive and therapeutic effects of rapamycin, a mammalian target of rapamycin inhibitor, on food allergy in mice

(2012) K. Yamaki et al.   ALLERGY

Prevention of Age-Related Macular Degeneration–Like Retinopathy by Rapamycin in Rats

(2012) Nataliya G. Kolosova et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan

(2012) Michael J. Steinbaugh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Short-Term Calorie Restriction Enhances Skeletal Muscle Stem Cell Function

(2012) Massimiliano Cerletti et al.   Cell Stem Cell

Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy

(2012) Robin C. C. Ryther et al.   Current Neurology and Neuroscience Reports

Rapamycin Preconditioning Attenuates Transient Focal Cerebral Ischemia/Reperfusion Injury in Mice

(2012) Lele Yin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice

(2012) E. Amiel et al.   JOURNAL OF IMMUNOLOGY

A healthy diet for stem cells

(2012) Fresnida J. Ramos et al.   NATURE

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

(2012) Peter T. Tsai et al.   NATURE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

(2011) Scott F. Leiser et al.   AGING CELL

Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

(2011) Smita Majumder et al.   AGING CELL

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

(2011) Aric N. Rogers et al.   Cell Metabolism

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Haploinsufficiency of Target of Rapamycin Attenuates Cardiomyopathies in Adult Zebrafish

(2011) Yonghe Ding et al.   CIRCULATION RESEARCH

mTOR Signaling and Metabolic Regulation of T Cells: New Potential Therapeutic Targets in Autoimmune Diseases

(2011) Marina Pierdominici et al.   CURRENT PHARMACEUTICAL DESIGN

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Inducing Autophagy by Rapamycin Before, but Not After, the Formation of Plaques and Tangles Ameliorates Cognitive Deficits

(2011) Smita Majumder et al.   PLoS One

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

Hot topics in aging research: protein translation and TOR signaling, 2010

(2010) Matt Kaeberlein et al.   AGING CELL

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

(2010) Scott F. Leiser et al.   BIOLOGICAL CHEMISTRY

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

FOXO3a Regulates Glycolysis via Transcriptional Control of Tumor Suppressor TSC1

(2010) Shikha Khatri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

A RANDOMIZED PILOT STUDY OF SYSTEMIC IMMUNOSUPPRESSION IN THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION WITH CHOROIDAL NEOVASCULARIZATION

(2010) Robert B Nussenblatt et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

The TOR pathway comes of age

(2009) Monique N. Stanfel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Oral rapamycin attenuates inflammation and enhances stability of atherosclerotic plaques in rabbits independent of serum lipid levels

(2009) Wen Qiang Chen et al.   BRITISH JOURNAL OF PHARMACOLOGY

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

(2009) Brian M. Zid et al.   CELL

Targeting mTOR: Something Old, Something New

(2009) K. Garber   JNCI-Journal of the National Cancer Institute

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

(2009) Yi Zhang et al.   PLoS One

Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans

(2009) R. Mehta et al.   SCIENCE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Molecular inflammation: Underpinnings of aging and age-related diseases

(2008) Hae Young Chung et al.   AGEING RESEARCH REVIEWS

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS