Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Cellular senescence: Immunosurveillance and future immunotherapy

(2018) Dominick G.A. Burton et al.   AGEING RESEARCH REVIEWS

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function

(2017) John van Tuyn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Clinical Potential of Senolytic Drugs

(2017) James L. Kirkland et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

(2016) Tobias Eggert et al.   CANCER CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E

(2016) S. G. Hansen et al.   SCIENCE

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells

(2015) L. Ruggeri et al.   HAEMATOLOGICA

A genomics approach identifies senescence-specific gene expression regulation

(2014) Daniel H. Lackner et al.   AGING CELL

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Effect of age and CMV on NK cell subpopulations

(2014) Carmen Campos et al.   EXPERIMENTAL GERONTOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Interactions between HLA-G and HLA-E in Physiological and Pathological Conditions

(2014) Fabio Morandi et al.   Frontiers in Immunology

The impact of ageing on natural killer cell function and potential consequences for health in older adults

(2013) Jon Hazeldine et al.   AGEING RESEARCH REVIEWS

Regulation of Ligands for the NKG2D Activating Receptor

(2013) David H. Raulet et al.   Annual Review of Immunology

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

(2013) Alexandre Iannello et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

PKC signaling prevents irradiation-induced apoptosis of primary human fibroblasts

(2013) A Bluwstein et al.   Cell Death & Disease

Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts

(2013) Malini Vangipuram et al.   Jove-Journal of Visualized Experiments

Role of non-classical MHC class I molecules in cancer immunosuppression

(2013) Grazyna Kochan et al.   OncoImmunology

The number of p16INK4a positive cells in human skin reflects biological age

(2012) Mariëtte E.C. Waaijer et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies

(2012) L. Hoenicke et al.   CARCINOGENESIS

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

(2012) C. M. Rudin et al.   CLINICAL CANCER RESEARCH

Human NKG2A overrides NKG2C effector functions to prevent autoreactivity of NK cells

(2011) V. Beziat et al.   BLOOD

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Human NK cells display major phenotypic and functional changes over the life span

(2010) Magali Le Garff-Tavernier et al.   AGING CELL

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress

(2010) Thorbald van Hall et al.   MICROBES AND INFECTION

KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells

(2009) S. M. Henson et al.   BLOOD

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Relationship between CD107a expression and cytotoxic activity

(2008) Esin Aktas et al.   CELLULAR IMMUNOLOGY

CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence

(2008) Emma J. Petrie et al.   JOURNAL OF EXPERIMENTAL MEDICINE