Interleukin-7 and Immunosenescence

Recombinant IL-7/HGFβ hybrid cytokine separates acute graft-versus-host-disease from graft-versus-tumour activity by altering donor T cell trafficking

(2016) Rong Hu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Repeated Cycles of Recombinant Human Interleukin 7 in HIV-Infected Patients With Low CD4 T-Cell Reconstitution on Antiretroviral Therapy: Results of 2 Phase II Multicenter Studies

(2016) Rodolphe Thiébaut et al.   CLINICAL INFECTIOUS DISEASES

Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia

(2016) Yuichiro Shindo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression

(2016) Naeem K. Patil et al.   PHARMACOLOGICAL RESEARCH

Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia

(2015) V. Sheikh et al.   BLOOD

The common γ-chain cytokine receptor: tricks-and-treats for T cells

(2015) Adam T. Waickman et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Age-associated telomere attrition of lymphocytesin vivois co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions

(2015) Yun Lin et al.   CLINICAL SCIENCE

Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

(2015) Kira Rubtsova et al.   JOURNAL OF IMMUNOLOGY

Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection

(2015) Moon Cheol Kang et al.   JOURNAL OF VIROLOGY

IL7R gene expression network associates with human healthy ageing

(2015) Willemijn M. Passtoors et al.   Immunity & Ageing

Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?

(2014) Qian Qi et al.   EXPERIMENTAL GERONTOLOGY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Homeostasis of the Naive CD4+ T Cell Compartment during Aging

(2014) R. D. Kilpatrick et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Autophagy is essential for effector CD8+ T cell survival and memory formation

(2014) Xiaojin Xu et al.   NATURE IMMUNOLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Interleukin-7 Mediates Selective Expansion of Tumor-redirected Cytotoxic T Lymphocytes (CTLs) without Enhancement of Regulatory T-cell Inhibition

(2013) S. K. Perna et al.   CLINICAL CANCER RESEARCH

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Postthymic Expansion in Human CD4 Naive T Cells Defined by Expression of Functional High-Affinity IL-2 Receptors

(2013) M. L. Pekalski et al.   JOURNAL OF IMMUNOLOGY

Two Separate Defects Affecting True Naive or Virtual Memory T Cell Precursors Combine To Reduce Naive T Cell Responses with Aging

(2013) K. R. Renkema et al.   JOURNAL OF IMMUNOLOGY

Soluble IL7R  potentiates IL-7 bioactivity and promotes autoimmunity

(2013) W. Lundstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis

(2013) So-Shin Ahn et al.   VACCINE

The Janus Head of T Cell Aging – Autoimmunity and Immunodeficiency

(2013) Jörg J. Goronzy et al.   Frontiers in Immunology

Mathematical Model of Naive T Cell Division and Survival IL-7 Thresholds

(2013) Joseph Reynolds et al.   Frontiers in Immunology

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

Genome-wide Association Study Identifies TNFSF15 and POU2AF1 as Susceptibility Loci for Primary Biliary Cirrhosis in the Japanese Population

(2012) Minoru Nakamura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Chronic inflammation and aging: DNA damage tips the balance

(2012) Mary M Cavanagh et al.   CURRENT OPINION IN IMMUNOLOGY

Interleukin-7: a key Mediator in T Cell-driven Autoimmunity, Inflammation, and Tissue Destruction

(2012) Angela Bikker et al.   CURRENT PHARMACEUTICAL DESIGN

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Structural insights into the common γ-chain family of cytokines and receptors from the interleukin-7 pathway

(2012) Scott T. R. Walsh   IMMUNOLOGICAL REVIEWS

Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations

(2012) Lorna W. Harries et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R

(2012) Willemijn M. Passtoors et al.   PLoS One

The influence of HIV on CD127 expression and its potential implications for IL-7 therapy

(2012) Angela M. Crawley et al.   SEMINARS IN IMMUNOLOGY

The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation

(2012) Steven A. Corfe et al.   SEMINARS IN IMMUNOLOGY

Central B-Cell Tolerance: Where Selection Begins

(2012) R. Pelanda et al.   Cold Spring Harbor Perspectives in Biology

IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology

(2011) Marc Pellegrini et al.   CELL

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Mitochondrial DNA mutations in disease and aging

(2011) Chan Bae Park et al.   JOURNAL OF CELL BIOLOGY

Gain-of-function mutations ininterleukin-7 receptor-α(IL7R) in childhood acute lymphoblastic leukemias

(2011) Chen Shochat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modulation of IL-7 Thresholds by SOCS Proteins in Developing B Lineage Cells

(2011) S. A. Corfe et al.   JOURNAL OF IMMUNOLOGY

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia

(2011) Priscila P Zenatti et al.   NATURE GENETICS

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Codelivery of IL-7 Augments Multigenic HCV DNA Vaccine-induced Antibody as well as Broad T Cell Responses in Cynomolgus Monkeys

(2011) Su-Hyung Park et al.   Immune Network

A Global Gene Expression Analysis of the Peripheral Blood Mononuclear Cells Reveals the Gene Expression Signature in Psoriasis

(2010) Sang-Keun Lee et al.   Annals of Dermatology

Galectins: regulators of acute and chronic inflammation

(2010) Fu-Tong Liu et al.   Annals of the New York Academy of Sciences

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

The pre-B cell receptor checkpoint

(2010) Inga-Lill Mårtensson et al.   FEBS LETTERS

Hallmark Features of Immunosenescence Are Absent in Familial Longevity

(2010) E. Derhovanessian et al.   JOURNAL OF IMMUNOLOGY

Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells

(2010) Adam S. Lazorchak et al.   MOLECULAR CELL

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

(2010) Eoin F McKinney et al.   NATURE MEDICINE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection

(2009) I. Sereti et al.   BLOOD

HEPATOCYTE GROWTH FACTOR PLAYS A CRITICAL ROLE IN THE REGULATION OF CYTOKINE PRODUCTION AND INDUCTION OF ENDOTHELIAL PROGENITOR CELL MOBILIZATION: A PILOT GENE THERAPY STUDY IN PATIENTS WITH CORONARY HEART DISEASE

(2009) Zhi-Jian Yang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Numb regulates cell–cell adhesion and polarity in response to tyrosine kinase signalling

(2009) Zezhou Wang et al.   EMBO JOURNAL

Marked enhancement of antigen-specific T-cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant

(2009) Hyo Jung Nam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Translational research to identify clinical applications of hepatocyte growth factor

(2009) Akio Ido et al.   HEPATOLOGY RESEARCH

An Essential Role of the Forkhead-Box Transcription Factor Foxo1 in Control of T Cell Homeostasis and Tolerance

(2009) Weiming Ouyang et al.   IMMUNITY

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis

(2009) Lan Shao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance

(2009) Jue Lin et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Modulating T-cell homeostasis with IL-7: preclinical and clinical studies

(2009) C. M. Capitini et al.   JOURNAL OF INTERNAL MEDICINE

Genetic Manipulation of Tumor-specific Cytotoxic T Lymphocytes to Restore Responsiveness to IL-7

(2009) Juan F Vera et al.   MOLECULAR THERAPY

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

(2009) Yann M Kerdiles et al.   NATURE IMMUNOLOGY

Rejuvenating the immune system in rheumatoid arthritis

(2009) Cornelia M. Weyand et al.   Nature Reviews Rheumatology

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma

(2009) Shadmehr Demehri et al.   PLOS BIOLOGY

HIV pathogenesis: 25 years of progress and persistent challenges

(2008) Jay A Levy   AIDS

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD

Results of a Double-Blind, Placebo-Controlled Study to Assess the Safety of Intramuscular Injection of Hepatocyte Growth Factor Plasmid to Improve Limb Perfusion in Patients With Critical Limb Ischemia

(2008) Richard J. Powell et al.   CIRCULATION

T cell subset-specific susceptibility to aging

(2008) Marta Czesnikiewicz-Guzik et al.   CLINICAL IMMUNOLOGY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

(2008) Claude Sportès et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease

(2008) Zhi-Jian Yang et al.   MOLECULAR BIOLOGY REPORTS