Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

FDA Approval Summary: Tocilizumab for Treatment of Chimeric Antigen Receptor T Cell‐Induced Severe or Life‐Threatening Cytokine Release Syndrome

(2018) Robert Q. Le et al.   ONCOLOGIST

Peripheral Blood B Cell Depletion after Rituximab and Complete Response in Lupus Nephritis

(2018) Liliana Michelle Gomez Mendez et al.   Clinical Journal of the American Society of Nephrology

The long and the short of it: insights into the cellular source of autoantibodies as revealed by B cell depletion therapy

(2018) Malika Hale et al.   CURRENT OPINION IN IMMUNOLOGY

T memory stem cells in health and disease

(2017) Luca Gattinoni et al.   NATURE MEDICINE

B-Cell Depletion — A Frontier in Monoclonal Antibodies for Multiple Sclerosis

(2017) Peter A. Calabresi   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

(2016) V. G. Bhoj et al.   BLOOD

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia

(2016) Paulina J. Paszkiewicz et al.   JOURNAL OF CLINICAL INVESTIGATION

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic forSle1and Human CD19

(2016) Sandra Gallagher et al.   Arthritis & Rheumatology

Vascular expression of annexin A2 in lupus nephritis

(2015) V Salle et al.   JOURNAL OF CLINICAL PATHOLOGY

Plasmazellen

(2015) F. Hiepe et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2015) Venkat Reddy et al.   Arthritis & Rheumatology

Label-free mass spectrometric profiling of urinary proteins and metabolites from paediatric idiopathic nephrotic syndrome

(2014) Mirela Sedic et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

B Cell Depletion with Anti-CD79 mAbs Ameliorates Autoimmune Disease in MRL/lpr Mice

(2014) Y. Li et al.   JOURNAL OF IMMUNOLOGY

Human effector T cells derived from central memory cells rather than CD8+T cells modified by tumor-specific TCR gene transfer possess superior traits for adoptive immunotherapy

(2013) Fenglin Wu et al.   CANCER LETTERS

Contributions of B cells to lupus pathogenesis

(2013) Allison Sang et al.   MOLECULAR IMMUNOLOGY

Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics

(2013) Ute Distler et al.   NATURE METHODS

CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia

(2013) Marco L. Davila et al.   PLoS One

Long-Lived Plasma Cells in Autoimmunity: Lessons from B-Cell Depleting Therapy

(2013) Matthieu Mahévas et al.   Frontiers in Immunology

Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning

(2012) H. J. Pegram et al.   BLOOD

Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice

(2012) Meera R. Krishnan et al.   KIDNEY INTERNATIONAL

An Acquired Defect in IgG-Dependent Phagocytosis Explains the Impairment in Antibody-Mediated Cellular Depletion in Lupus

(2011) A. Ahuja et al.   JOURNAL OF IMMUNOLOGY

Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus

(2010) Kai W. Bekar et al.   ARTHRITIS AND RHEUMATISM

Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

(2010) J. N. Kochenderfer et al.   BLOOD

Local Renal Autoantibody Production in Lupus Nephritis

(2010) M. Espeli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement Factor H Deficiency Accelerates Development of Lupus Nephritis

(2010) L. Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Activating systemic autoimmunity: B's, T's, and tolls

(2009) Mark J Shlomchik   CURRENT OPINION IN IMMUNOLOGY

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

(2009) Y. Zhao et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Primary and Secondary Effects of CD19 Deficiency on Cells of the Marginal Zone

(2009) Y. You et al.   JOURNAL OF IMMUNOLOGY

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE