Influence of Resveratrol on the Immune Response

Toll like receptors as a novel therapeutic target for natural products against chronic diseases

(2019) Arunaksharan Narayanankutty   CURRENT DRUG TARGETS

Resveratrol in Patients with Minimal Hepatic Encephalopathy

(2018) Giulia Malaguarnera et al.   Nutrients

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

(2018) Yu Tai et al.   Frontiers in Pharmacology

Engineering stilbene metabolic pathways in microbial cells

(2018) Philippe Jeandet et al.   BIOTECHNOLOGY ADVANCES

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets

(2018) Uzma Saqib et al.   Frontiers in Pharmacology

Nutritionally relevant concentrations of resveratrol and hydroxytyrosol mitigate oxidative burst of human granulocytes and monocytes and the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages

(2017) Elisabetta Bigagli et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Human regulatory B cells in health and disease: therapeutic potential

(2017) Claudia Mauri et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance

(2017) Manuela Pennisi et al.   Nutrients

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

Plasma cells as an innovative target in autoimmune disease with renal manifestations

(2016) Falk Hiepe et al.   Nature Reviews Nephrology

Resveratrol Prevents Tumor Growth and Metastasis by Inhibiting Lymphangiogenesis and M2 Macrophage Activation and Differentiation in Tumor-associated Macrophages

(2016) Yoshiyuki Kimura et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inverse role of distinct subsets and distribution of macrophage in lung cancer prognosis: a meta-analysis

(2016) Pin Wu et al.   Oncotarget

Prognostic impact of tumor-associated macrophage infiltration in non-small cell lung cancer: A systemic review and meta-analysis

(2016) Jiandong Mei et al.   Oncotarget

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice

(2016) Sokrates Stein et al.   Aging-US

Involvement of the IL-23/IL-17 axis and the Th17/Treg balance in the pathogenesis and control of autoimmune arthritis

(2015) Brian Astry et al.   CYTOKINE

Intercellular interplay between Sirt1 signalling and cell metabolism in immune cell biology

(2015) Xi Chen et al.   IMMUNOLOGY

Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome

(2015) Takuma Misawa et al.   INTERNATIONAL IMMUNOLOGY

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis

(2015) Bin-Zhi Qian et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic enzymes are the therapeutic targets for CD4+CD25+/highFoxp3+ regulatory T cells

(2015) Jahaira Lopez-Pastrana et al.   Translational Research

Functional and Phenotypic Plasticity of CD4+T Cell Subsets

(2015) Tiffany Caza et al.   Biomed Research International

Biocatalysis and biotransformation of resveratrol in microorganisms

(2014) Yan-Zhen Mei et al.   BIOTECHNOLOGY LETTERS

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development

(2014) J. Wang et al.   CANCER RESEARCH

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

(2014) Ying Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Interferon gamma induced by resveratrol analog, HS-1793, reverses the properties of tumor associated macrophages

(2014) Soo Kyung Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins

(2014) WENPENG DONG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Concentration-Dependent Biphasic Effects of Resveratrol on Human Natural Killer Cells in Vitro

(2014) Qi Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Resveratrol Possesses Protective Effects in a Pristane-Induced Lupus Mouse Model

(2014) Zhuo-Long Wang et al.   PLoS One

Effects of Cancer on Platelets

(2014) Nick van Es et al.   SEMINARS IN ONCOLOGY

Regulatory effects of resveratrol on glucose metabolism and T-lymphocyte subsets in the development of high-fat diet-induced obesity in C57BL/6 mice

(2014) Bin Wang et al.   Food & Function

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L

(2013) M. Bodogai et al.   CANCER RESEARCH

Resveratrol in Peanuts

(2013) Jocelyn M. Sales et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells

(2013) C. Lee-Chang et al.   JOURNAL OF IMMUNOLOGY

Resveratrol Induces Cell Cycle Arrest and Apoptosis in Malignant NK Cells via JAK2/STAT3 Pathway Inhibition

(2013) Ly Quoc Trung et al.   PLoS One

Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1

(2013) Ting Zou et al.   PLoS One

Enhanced anti-inflammatory effect of resveratrol and EPA in treated endotoxin-activated RAW 264.7 macrophages

(2012) Victor Pallarès et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors

(2012) Liangshan Hu et al.   CANCER BIOLOGY & THERAPY

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Resveratrol Enhances the Antitumor Effects of Temozolomide in Glioblastoma via ROS-dependent AMPK-TSC-mTOR Signaling Pathway

(2012) Yuan Yuan et al.   CNS Neuroscience & Therapeutics

Tuning the threshold of natural killer cell responses

(2012) Emilie Narni-Mancinelli et al.   CURRENT OPINION IN IMMUNOLOGY

Analysis of lymphocyte subsets in HIV-negative neurosyphilis patients

(2012) Li-Li Liu et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Resveratrol mediates anti-atherogenic effects on cholesterol flux in human macrophages and endothelium via PPARγ and adenosine

(2012) Iryna Voloshyna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+CD25+ regulatory T cells in FM3A tumor bearing mice

(2012) Min Ho Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-inflammatory Effects of Resveratrol and Its Potential Use in Therapy of Immune-mediated Diseases

(2012) Urban Švajger et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A Novel IL-10-Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand

(2012) A. Ray et al.   JOURNAL OF IMMUNOLOGY

Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells

(2012) H.-S. Kwon et al.   JOURNAL OF IMMUNOLOGY

TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol

(2012) Peter B. Jakus et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

Sirtuins mediate mammalian metabolic responses to nutrient availability

(2012) Angeliki Chalkiadaki et al.   Nature Reviews Endocrinology

The Anticancer Effects of Resveratrol: Modulation of Transcription Factors

(2012) Nichelle C. Whitlock et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

(2012) B. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function

(2011) Gao Xuzhu et al.   ANNALS OF THE RHEUMATIC DISEASES

Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2−/−IL-2Rγ−/− mice: A promising model for studying human disease

(2011) Danieli Andrade et al.   ARTHRITIS AND RHEUMATISM

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Resveratrol: A multitargeted agent for age-associated chronic diseases

(2011) Kuzhuvelil B. Harikumar et al.   CELL CYCLE

Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes

(2011) S.-M. Lee et al.   DIABETOLOGIA

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

(2011) Mehdi Shakibaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade

(2011) Hemachander Capiralla et al.   JOURNAL OF NEUROCHEMISTRY

Biological activity of piceatannol: Leaving the shadow of resveratrol

(2011) Hanna Piotrowska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

(2011) Thomas Krausgruber et al.   NATURE IMMUNOLOGY

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection

(2011) Mikayla R. Thompson et al.   Viruses-Basel

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells?

(2010) Guillaume Jacquemin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

(2010) Attila Szanto et al.   IMMUNITY

Regulatory role of resveratrol on Th17 in autoimmune disease

(2010) Thomas M. Petro   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways

(2010) Chia-Chen Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diet-Induced Obesity Impairs the T Cell Memory Response to Influenza Virus Infection

(2010) E. A. Karlsson et al.   JOURNAL OF IMMUNOLOGY

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner

(2010) Hiroshi Nakayama et al.   RHEUMATOLOGY INTERNATIONAL

Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway

(2009) Hichem Sebai et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1

(2009) Dae-Weon Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

(2009) Jinping Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

The killer's kiss: the many functions of NK cell immunological synapses

(2008) Konrad Krzewski et al.   CURRENT OPINION IN CELL BIOLOGY

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

Physiological up-regulation of inhibitory receptors Fc RII and CR1 on memory B cells is lacking in SLE patients

(2008) A. Isaak et al.   INTERNATIONAL IMMUNOLOGY

Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells

(2008) Yoolhee Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resveratrol ameliorates Serratia marcescens-induced acute pneumonia in rats

(2008) C.-C. Lu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

trans-resveratrol alone and hydroxystilbenes of rhubarb (Rheum rhaponticumL.) root reduce liver damage induced by chronic ethanol administration: a comparative study in mice

(2008) Ain Raal et al.   PHYTOTHERAPY RESEARCH

Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression

(2007) Vladimir N. Ivanov et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?

(2007) Philipp Saiko et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH