Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
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Title
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Authors
Keywords
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Journal
Immunity & Ageing
Volume 17, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-20
DOI
10.1186/s12979-020-0173-8
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Note: Only part of the references are listed.- An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses
- (2019) Melissa A. Brown et al. JOURNAL OF IMMUNOLOGY
- Mosaicism, aging and cancer
- (2019) Mitchell J. Machiela CURRENT OPINION IN ONCOLOGY
- Triglycerides and cardiovascular risk: Apolipoprotein B holds the key
- (2019) Jane Stock ATHEROSCLEROSIS
- Senescent cell clearance by the immune system: Emerging therapeutic opportunities
- (2019) Larissa G.P. Langhi Prata et al. SEMINARS IN IMMUNOLOGY
- Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease
- (2019) Rashmi Das et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Dangerous γδ T cells in aged mice
- (2019) Immo Prinz et al. EMBO REPORTS
- IL ‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response
- (2019) Hung‐Chang Chen et al. EMBO REPORTS
- The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis
- (2019) Summerhill et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Myeloid-Derived Suppressor Cells: Not Only in Tumor Immunity
- (2019) Graham Pawelec et al. Frontiers in Immunology
- Molecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease
- (2018) Jean-François Ghersi-Egea et al. ACTA NEUROPATHOLOGICA
- Cellular senescence: Immunosurveillance and future immunotherapy
- (2018) Dominick G.A. Burton et al. AGEING RESEARCH REVIEWS
- Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
- (2018) Niharika Arora Duggal et al. AGING CELL
- Exercise and taurine in inflammation, cognition, and peripheral markers of blood-brain barrier integrity in older women
- (2018) Matheus Uba Chupel et al. Applied Physiology Nutrition and Metabolism
- Regulatory CD4+T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B
- (2018) Takayuki Kimura et al. CIRCULATION
- Age and immunity: What is “immunosenescence”?
- (2018) Graham Pawelec EXPERIMENTAL GERONTOLOGY
- Atrophied Thymus, a Tumor reservoir for Harboring Melanoma Cells
- (2018) Olga Sizova et al. MOLECULAR CANCER RESEARCH
- Myeloid-derived suppressor cells coming of age
- (2018) Filippo Veglia et al. NATURE IMMUNOLOGY
- Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions
- (2018) Michelle A. Erickson et al. PHARMACOLOGICAL REVIEWS
- Thymic involution and rising disease incidence with age
- (2018) Sam Palmer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hallmarks of Cellular Senescence
- (2018) Alejandra Hernandez-Segura et al. TRENDS IN CELL BIOLOGY
- Immune-inflammatory responses in the elderly: an update
- (2018) Giulia Accardi et al. Immunity & Ageing
- Interventions to restore appropriate immune function in the elderly
- (2018) Richard Aspinall et al. Immunity & Ageing
- Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
- (2018) Tamas Fulop et al. Frontiers in Immunology
- Age-stratified Patterns of Thymic Involution on Multidetector CT
- (2018) Michael J. Drabkin et al. JOURNAL OF THORACIC IMAGING
- Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells
- (2018) Jelka Pohar et al. Frontiers in Immunology
- Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives
- (2018) Rita Del Pinto et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inflammaging 2018: An update and a model
- (2018) Claudio Franceschi et al. SEMINARS IN IMMUNOLOGY
- Aging, inflammation and cancer
- (2018) Barbara Bottazzi et al. SEMINARS IN IMMUNOLOGY
- The integration of inflammaging in age-related diseases
- (2018) Tamas Fulop et al. SEMINARS IN IMMUNOLOGY
- Age-Dependent Changes in Regulatory T Lymphocyte Development and Function: A Mini-Review
- (2017) Julie Darrigues et al. GERONTOLOGY
- Human T cell immunosenescence and inflammation in aging
- (2017) Arsun Bektas et al. JOURNAL OF LEUKOCYTE BIOLOGY
- The Aging Cardiovascular System
- (2017) Francesco Paneni et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The blood-brain barrier in Alzheimer's disease
- (2017) Elena Zenaro et al. NEUROBIOLOGY OF DISEASE
- Impact of aging immune system on neurodegeneration and potential immunotherapies
- (2017) Zhanfeng Liang et al. PROGRESS IN NEUROBIOLOGY
- The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging
- (2017) Sarah E. Latchney et al. SEMINARS IN HEMATOLOGY
- Capacity of tTreg generation is not impaired in the atrophied thymus
- (2017) Jiyoung Oh et al. PLOS BIOLOGY
- Cancer and Aging - the Inflammatory Connection
- (2017) Adar Zinger et al. Aging and Disease
- T-Cells Specific for a Self-Peptide of ApoB-100 Exacerbate Aortic Atheroma in Murine Atherosclerosis
- (2017) Michael K. Shaw et al. Frontiers in Immunology
- Age-related changes in CD4+CD25+FOXP3+ regulatory T cells and their relationship with lung cancer
- (2017) Pan-Fei Hou et al. PLoS One
- Phenotypic characteristics of aged CD4+ CD28null T lymphocytes are determined by changes in the whole-genome DNA methylation pattern
- (2016) Beatriz Suarez-Álvarez et al. AGING CELL
- A novel Foxn1eGFP/+ mouse model identifies Bmp4-induced maintenance of Foxn1 expression and thymic epithelial progenitor populations
- (2016) Marco Barsanti et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- FOXN1 in thymus organogenesis and development
- (2016) Harsh Jayesh Vaidya et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses
- (2016) Eric H. Bent et al. GENES & DEVELOPMENT
- Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage
- (2016) Sven Malchow et al. IMMUNITY
- Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity
- (2016) Elisa Kieback et al. IMMUNITY
- Thymus: the next (re)generation
- (2016) Mohammed S. Chaudhry et al. IMMUNOLOGICAL REVIEWS
- T-cell selection in the thymus: a spatial and temporal perspective
- (2016) Nadia Kurd et al. IMMUNOLOGICAL REVIEWS
- Roles of regulatory T cells in cancer immunity
- (2016) Yoshiko Takeuchi et al. INTERNATIONAL IMMUNOLOGY
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- (2016) Pearl Bakhru et al. JOURNAL OF CLINICAL INVESTIGATION
- Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases
- (2016) Nadine Dragin et al. JOURNAL OF CLINICAL INVESTIGATION
- Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
- (2016) Aleksandra Deczkowska et al. TRENDS IN IMMUNOLOGY
- Role of interleukin-6 in cancer progression and therapeutic resistance
- (2016) Neeraj Kumari et al. TUMOR BIOLOGY
- Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
- (2016) Megan K. Ruhland et al. Nature Communications
- Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment
- (2016) Larisa V. Kovtonyuk et al. Frontiers in Immunology
- Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus
- (2016) Liguang Sun et al. Aging-US
- Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution
- (2016) Kathy E. O’Neill et al. PLoS One
- Trade off situation between thymus and growth hormone: age-related decline of growth hormone is a cause of thymic involution but favorable for elongation of lifespan
- (2015) Katsuiku Hirokawa et al. BIOGERONTOLOGY
- A proposed panel of biomarkers of healthy ageing
- (2015) Jose Lara et al. BMC Medicine
- T cell senescence and cardiovascular diseases
- (2015) Hee Tae Yu et al. CLINICAL AND EXPERIMENTAL MEDICINE
- Normal thymus in adults: appearance on CT and associations with age, sex, BMI and smoking
- (2015) Tetsuro Araki et al. EUROPEAN RADIOLOGY
- Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
- (2015) Mi-Jeong Kim et al. JOURNAL OF IMMUNOLOGY
- Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques
- (2015) Afam A. Okoye et al. JOURNAL OF IMMUNOLOGY
- Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus
- (2015) Immanuel Rode et al. JOURNAL OF IMMUNOLOGY
- Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation
- (2015) Brandon D. Coder et al. JOURNAL OF IMMUNOLOGY
- Hormonal control of T-cell development in health and disease
- (2015) Wilson Savino et al. Nature Reviews Endocrinology
- Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
- (2015) Kuti Baruch et al. Nature Communications
- Thymic involution beyond T-cell insufficiency
- (2015) Brandon Coder et al. Oncotarget
- Geroscience: Linking Aging to Chronic Disease
- (2014) Brian K. Kennedy et al. CELL
- Regeneration of the aged thymus by a single transcription factor
- (2014) N. Bredenkamp et al. DEVELOPMENT
- Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10
- (2014) Luokun Xie et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Mechanisms shaping the naïve T cell repertoire in the elderly — Thymic involution or peripheral homeostatic proliferation?
- (2014) Qian Qi et al. EXPERIMENTAL GERONTOLOGY
- Regulatory T Cells and the Immune Aging Process: A Mini-Review
- (2014) Ann Jagger et al. GERONTOLOGY
- Sex steroid blockade enhances thymopoiesis by modulating Notch signaling
- (2014) Enrico Velardi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation
- (2014) C. S. Lages et al. JOURNAL OF IMMUNOLOGY
- Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus
- (2014) C. Ferreira et al. JOURNAL OF IMMUNOLOGY
- An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts
- (2014) Nicholas Bredenkamp et al. NATURE CELL BIOLOGY
- Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
- (2014) Saul A Villeda et al. NATURE MEDICINE
- Aging-induced type I interferon response at the choroid plexus negatively affects brain function
- (2014) K. Baruch et al. SCIENCE
- Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- (2014) L. Katsimpardi et al. SCIENCE
- Chronic Inflammation and Cytokines in the Tumor Microenvironment
- (2014) Glauben Landskron et al. Journal of Immunology Research
- FOXN1GFP/w Reporter hESCs Enable Identification of Integrin-β4, HLA-DR, and EpCAM as Markers of Human PSC-Derived FOXN1+ Thymic Epithelial Progenitors
- (2014) Chew-Li Soh et al. Stem Cell Reports
- Thymus and aging: morphological, radiological, and functional overview
- (2013) Rita Rezzani et al. AGE
- Aging is associated with increased regulatory T-cell function
- (2013) Sanjay K. Garg et al. AGING CELL
- IFN-γ-dependent activation of the brain’s choroid plexus for CNS immune surveillance and repair
- (2013) Gilad Kunis et al. BRAIN
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Generation of Functional Thymic Epithelium from Human Embryonic Stem Cells that Supports Host T Cell Development
- (2013) Audrey V. Parent et al. Cell Stem Cell
- Directed Differentiation of Human Embryonic Stem Cells into Thymic Epithelial Progenitor-like Cells Reconstitutes the Thymic Microenvironment In Vivo
- (2013) Xiaoning Sun et al. Cell Stem Cell
- Acute ablation of DP thymocytes induces up-regulation of IL-22 and Foxn1 in TECs
- (2013) Bin Pan et al. CLINICAL IMMUNOLOGY
- Immunosenescence: a product of the environment?
- (2013) Dong-Ming Su et al. CURRENT OPINION IN IMMUNOLOGY
- T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
- (2013) Joel Crespo et al. CURRENT OPINION IN IMMUNOLOGY
- Immune senescence and cancer in elderly patients: Results from an exploratory study
- (2013) Cristina Falci et al. EXPERIMENTAL GERONTOLOGY
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- IFN- Production by Amyloid -Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease
- (2013) T. C. Browne et al. JOURNAL OF IMMUNOLOGY
- Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
- (2013) Anna Cebula et al. NATURE
- Circulating and Tumor-Infiltrating Myeloid-Derived Suppressor Cells in Patients with Colorectal Carcinoma
- (2013) Bin Zhang et al. PLoS One
- Systemic Transplantation of Human Umbilical Cord Derived Mesenchymal Stem Cells-Educated T Regulatory Cells Improved the Impaired Cognition in AβPPswe/PS1dE9 Transgenic Mice
- (2013) Hongna Yang et al. PLoS One
- Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats
- (2013) Jun Zhang et al. PLoS One
- CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging
- (2013) K. Baruch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models
- (2013) E. Ammirati et al. Journal of the American Heart Association
- The Impact of Aging on Regulatory T-Cells
- (2013) Johannes Fessler et al. Frontiers in Immunology
- The Effect of Age on Thymic Function
- (2013) Donald B. Palmer Frontiers in Immunology
- Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors
- (2013) Sven Malchow et al. OncoImmunology
- Histone Modifications in Senescence-Associated Resistance to Apoptosis by Oxidative Stress
- (2013) Yan Y. Sanders et al. Redox Biology
- Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells
- (2012) Lishi Sun et al. AGING CELL
- Selection of Self-Reactive T Cells in the Thymus
- (2012) Gretta L. Stritesky et al. Annual Review of Immunology
- The circulatory systemic environment as a modulator of neurogenesis and brain aging
- (2012) Saul A. Villeda et al. AUTOIMMUNITY REVIEWS
- Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
- (2012) M.-A. Perales et al. BLOOD
- The Biological Role of Inflammation in Atherosclerosis
- (2012) Brian W. Wong et al. CANADIAN JOURNAL OF CARDIOLOGY
- Rejuvenation of Regeneration in the Aging Central Nervous System
- (2012) Julia M. Ruckh et al. Cell Stem Cell
- The Intersection Between Aging and Cardiovascular Disease
- (2012) Brian J. North et al. CIRCULATION RESEARCH
- Homeostasis and function of regulatory T cells in aging
- (2012) Jana Raynor et al. CURRENT OPINION IN IMMUNOLOGY
- Insights on Foxn1 Biological Significance and Usages of the “Nude” Mouse in Studies of T-Lymphopoiesis
- (2012) Zhijie Zhang et al. International Journal of Biological Sciences
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- Granule exocytosis mediates immune surveillance of senescent cells
- (2012) A Sagiv et al. ONCOGENE
- Accelerated Aging versus Rejuvenation of the Immune System in Heterochronic Parabiosis
- (2012) Iryna Pishel et al. REJUVENATION RESEARCH
- Rebuilding the Thymus
- (2012) A. Bhandoola et al. SCIENCE
- Interleukin-22 Drives Endogenous Thymic Regeneration in Mice
- (2012) J. A. Dudakov et al. SCIENCE
- Changes in primary lymphoid organs with aging
- (2012) Ivan K. Chinn et al. SEMINARS IN IMMUNOLOGY
- Translational research in immune senescence: Assessing the relevance of current models
- (2012) Kevin P. High et al. SEMINARS IN IMMUNOLOGY
- Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans
- (2012) Rafael Solana et al. SEMINARS IN IMMUNOLOGY
- Concise Review: Hematopoietic Stem Cell Aging, Life Span, and Transplantation
- (2012) Gary Van Zant et al. Stem Cells Translational Medicine
- Persistent degenerative changes in thymic organ function revealed by an inducible model of organ regrowth
- (2011) Ann V. Griffith et al. AGING CELL
- Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells
- (2011) E. C. Zook et al. BLOOD
- Forecasting the Future of Cardiovascular Disease in the United States
- (2011) Paul A. Heidenreich et al. CIRCULATION
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function
- (2011) Saul A. Villeda et al. NATURE
- Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
- (2011) W. W. Pang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Persistent viral infections and immune aging
- (2010) Stefan Brunner et al. AGEING RESEARCH REVIEWS
- Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution
- (2010) Liguang Sun et al. AGING CELL
- The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
- (2010) Jean-Philippe Coppé et al. Annual Review of Pathology-Mechanisms of Disease
- DNA Damage-Mediated Induction of a Chemoresistant Niche
- (2010) Luke A. Gilbert et al. CELL
- Cellular senescence: putting the paradoxes in perspective
- (2010) Judith Campisi CURRENT OPINION IN GENETICS & DEVELOPMENT
- Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes
- (2010) Gerald Wirnsberger et al. IMMUNOLOGY AND CELL BIOLOGY
- Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects
- (2010) H. Tsukamoto et al. JOURNAL OF IMMUNOLOGY
- A Major Role for Bim in Regulatory T Cell Homeostasis
- (2010) C. A. Chougnet et al. JOURNAL OF IMMUNOLOGY
- Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance
- (2010) Maria Hinterberger et al. NATURE IMMUNOLOGY
- Inflammatory networks during cellular senescence: causes and consequences
- (2010) Adam Freund et al. TRENDS IN MOLECULAR MEDICINE
- Effects of aging on hematopoietic stem and progenitor cells
- (2009) Amanda Waterstrat et al. CURRENT OPINION IN IMMUNOLOGY
- Immunosenescence: what does it mean to health outcomes in older adults?
- (2009) Janet E McElhaney et al. CURRENT OPINION IN IMMUNOLOGY
- Postnatal Tissue-specific Disruption of Transcription Factor FoxN1 Triggers Acute Thymic Atrophy
- (2009) Lili Cheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reduced Thymic Aire Expression and Abnormal NF- B2 Signaling in a Model of Systemic Autoimmunity
- (2009) A. L. Fletcher et al. JOURNAL OF IMMUNOLOGY
- Aβ-specific Th2 cells provide cognitive and pathological benefits to Alzheimer's mice without infiltrating the CNS
- (2009) Chuanhai Cao et al. NEUROBIOLOGY OF DISEASE
- Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells
- (2009) C. Ferreira et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
- (2009) H. Tsukamoto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory T Cells and Immune Tolerance
- (2008) Shimon Sakaguchi et al. CELL
- Antigen-specific peripheral shaping of the natural regulatory T cell population
- (2008) Stephanie K. Lathrop et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
- (2008) Jean-Philippe Coppé et al. PLOS BIOLOGY
- Regulatory T Cells: Mechanisms of Differentiation and Function
- (2007) Steven Z. Josefowicz et al. Annual Review of Immunology
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