Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

Cryo-EM structures of Toll-like receptors in complex with UNC93B1

(2021) Hanako Ishida et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural comparison of GLUT1 to GLUT3 reveal transport regulation mechanism in sugar porter family

(2021) Tânia Filipa Custódio et al.   Life Science Alliance

Protein structure reveals how a malaria parasite imports a wide range of sugars

(2020) Thorsten Althoff et al.   NATURE

The molecular basis for sugar import in malaria parasites

(2020) Abdul Aziz Qureshi et al.   NATURE

Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

(2020) Melanie A. Felmlee et al.   PHARMACOLOGICAL REVIEWS

Structure and mechanism of a redesigned multidrug transporter from the Major Facilitator Superfamily

(2020) Hsin-Hui Wu et al.   Scientific Reports

Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps

(2020) Sanath Kumar et al.   Microorganisms

Elevator-type mechanisms of membrane transport

(2020) Alisa A. Garaeva et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Recent advances in understanding prodrug transport through the SLC15 family of proton-coupled transporters

(2020) Gurdeep S. Minhas et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

(2020) Enrico Girardi et al.   Nature Chemical Biology

Transporters of glucose and other carbohydrates in bacteria

(2020) Jean-Marc Jeckelmann et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Ion transport and regulation in a synaptic vesicle glutamate transporter

(2020) Fei Li et al.   SCIENCE

Synthetic antibodies against BRIL as universal fiducial marks for single−particle cryoEM structure determination of membrane proteins

(2020) Somnath Mukherjee et al.   Nature Communications

Cooperative transport mechanism of human monocarboxylate transporter 2

(2020) Bo Zhang et al.   Nature Communications

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

(2020) Per Plenge et al.   Nature Communications

Membrane Chemistry Tunes the Structure of a Peptide Transporter

(2020) Tanya Lasitza-Male et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity

(2020) Vincent Debruycker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Genomic and Transcriptomic Overview of MATE, ABC, and MFS Transporters in Citrus sinensis Interaction with Xanthomonas citri subsp. citri

(2020) Maria H. M. Julião et al.   Plants-Basel

Current problems and future avenues in proteoliposome research

(2020) Andrea Marco Amati et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Expansion of the Major Facilitator Superfamily (MFS) to include novel transporters as well as transmembrane-acting enzymes

(2020) Steven C. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum

(2020) Xin Jiang et al.   CELL

Asp22 drives the protonation state of the Staphylococcus epidermidis glucose/H+ symporter

(2020) Ana Filipa Santos Seiça et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Multidrug Transporter MdfA Deviates from the Canonical Model of Alternating Access of MFS Transporters

(2020) Eliane H. Yardeni et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

(2020) Christian B. Billesbølle et al.   NATURE

Visualizing the nonlinear changes of a drug-proton antiporter from inward-open to occluded state

(2020) Qingjie Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates

(2020) Nan Wang et al.   CELL

Toward a Molecular Basis of Cellular Nucleoside Transport in Humans

(2020) Nicholas J. Wright et al.   CHEMICAL REVIEWS

Energy coupling of membrane transport and efficiency of sucrose dissimilation in yeast

(2020) Ryan K. Henderson et al.   METABOLIC ENGINEERING

The structural basis of promiscuity in small multidrug resistance transporters

(2020) Ali A. Kermani et al.   Nature Communications

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

(2020) Ruyu Jia et al.   Nature Communications

Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

(2019) Yonca Ural-Blimke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced functionalisation of major facilitator superfamily transporters via fusion of C-terminal protein domains is both extensive and varied in bacteria

(2019) Benjamin J. Willson et al.   MICROBIOLOGY-SGM

Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters

(2019) Gurdeep S. Minhas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs

(2019) Xin Jiang et al.   Cell Discovery

New insights into GluT1 mechanics during glucose transfer

(2019) Tatiana Galochkina et al.   Scientific Reports

Crystal structure of the plant symporter STP10 illuminates sugar uptake mechanism in monosaccharide transporter superfamily

(2019) Peter Aasted Paulsen et al.   Nature Communications

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

smFRET Probing Reveals Substrate-Dependent Conformational Dynamics of E. coli Multidrug MdfA

(2019) Yongping Zhu et al.   BIOPHYSICAL JOURNAL

Structural basis for the delivery of activated sialic acid into Golgi for sialyation

(2019) Emmanuel Nji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures suggest a mechanism for energy coupling by a family of organic anion transporters

(2019) Jonathan B. Leano et al.   PLOS BIOLOGY

A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion

(2019) Katarina Valoskova et al.   eLife

Structural basis for oligomerization of the prokaryotic peptide transporter PepTSo2

(2019) Reina Nagamura et al.   Acta Crystallographica Section F-Structural Biology Communications

It takes two to tango: The dance of the permease

(2019) H. Ronald Kaback et al.   JOURNAL OF GENERAL PHYSIOLOGY

More Transporters, More Substrates: The Arabidopsis Major Facilitator Superfamily Revisited

(2019) María Niño-González et al.   Molecular Plant

Insights into L-type heteromeric amino acid transporters

(2019) Simon Newstead   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

(2019) Yongchan Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of human ENT1 in complex with adenosine reuptake inhibitors

(2019) Nicholas J. Wright et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic basis of L-lactate transport in the SLC16 solute carrier family

(2019) Patrick D. Bosshart et al.   Nature Communications

The transporters SLC35A1 and SLC30A1 play opposite roles in cell survival upon VSV virus infection

(2019) Anna Moskovskich et al.   Scientific Reports

Monocarboxylate transporters in cancer

(2019) Valéry L. Payen et al.   Molecular Metabolism

The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells

(2019) Pasqua et al.   Microorganisms

Feedforward Control of Plant Nitrate Transporter NRT1.1 Biphasic Adaptive Activity

(2019) Mubasher Rashid et al.   BIOPHYSICAL JOURNAL

Evolutionary dynamics of membrane transporters and channels: enhancing function through fusion

(2019) Benjamin J Willson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Isolation and structural characterization of a Zn2+-bound single-domain antibody against NorC, a putative multi-drug efflux transporter in bacteria

(2019) Sushant Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

(2019) Jonathan J. Ruprecht et al.   TRENDS IN BIOCHEMICAL SCIENCES

Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels

(2019) Eliane H. Yardeni et al.   Scientific Reports

The Druggability of Solute Carriers

(2019) Wesley Wei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

The SLC22 Transporter Family: A Paradigm for the Impact of Drug Transporters on Metabolic Pathways, Signaling, and Disease

(2018) Sanjay K. Nigam   Annual Review of Pharmacology and Toxicology

Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

(2018) Nanda G. Aduri et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Applications of sequence coevolution in membrane protein biochemistry

(2018) John M. Nicoludis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conformational landscapes of membrane proteins delineated by enhanced sampling molecular dynamics simulations

(2018) Tyler J. Harpole et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease

(2018) Jose D. Pagan et al.   CELL

Glucose transporters in cancer - from tumor cells to the tumor microenvironment

(2018) Pierre-Benoit Ancey et al.   FEBS Journal

The ins and outs of vesicular monoamine transporters

(2018) Dana Yaffe et al.   JOURNAL OF GENERAL PHYSIOLOGY

A New Critical Conformational Determinant of Multidrug Efflux by an MFS Transporter

(2018) Elia Zomot et al.   JOURNAL OF MOLECULAR BIOLOGY

Understanding the diversity of membrane lipid composition

(2018) Takeshi Harayama et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization

(2018) Luca Ponzoni et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Multispecific Substrate Recognition in a Proton-Dependent Oligopeptide Transporter

(2018) Maria Martinez Molledo et al.   STRUCTURE

Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae

(2018) Peter Scharff-Poulsen et al.   G3-Genes Genomes Genetics

Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!

(2018) Mafalda Cavalheiro et al.   Genes

Structural and functional characterization of protein–lipid interactions of the Salmonella typhimurium melibiose transporter MelB

(2018) Parameswaran Hariharan et al.   BMC BIOLOGY

Membrane protein structural biology in the era of single particle cryo-EM

(2018) Yifan Cheng   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tripeptide binding in a proton-dependent oligopeptide transporter

(2018) Maria Martinez Molledo et al.   FEBS LETTERS

Single-particle cryo-EM—How did it get here and where will it go

(2018) Yifan Cheng   SCIENCE

Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism

(2018) Kumar Nagarathinam et al.   Nature Communications

Uptake dynamics in the Lactose permease (LacY) membrane protein transporter

(2018) D. Kimanius et al.   Scientific Reports

The dual role of chloride in synaptic vesicle glutamate transport

(2018) Roger Chang et al.   eLife

Chemical biology probes of mammalian GLUT structure and function

(2018) Geoffrey D. Holman   BIOCHEMICAL JOURNAL

Direct protein-lipid interactions shape the conformational landscape of secondary transporters

(2018) Chloe Martens et al.   Nature Communications

An engineered thermal-shift screen reveals specific lipid preferences of eukaryotic and prokaryotic membrane proteins

(2018) Emmanuel Nji et al.   Nature Communications

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

(2018) Don Benjamin et al.   Cell Reports

Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

(2018) Homa Majd et al.   eLife

Coupling efficiency of secondary active transporters

(2018) Ryan K Henderson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Impact of Membrane Phospholipid Alterations in Escherichia coli on Cellular Function and Bacterial Stress Adaptation

(2017) Veronica W. Rowlett et al.   JOURNAL OF BACTERIOLOGY

The prototypical proton-coupled oligopeptide transporter YdgR fromEscherichia colifacilitates chloramphenicol uptake into bacterial cells

(2017) Bala K. Prabhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate (un)specificity of Arabidopsis NRT1/PTR FAMILY (NPF) proteins

(2017) Claire Corratgé-Faillie et al.   JOURNAL OF EXPERIMENTAL BOTANY

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

Structure determination of a major facilitator peptide transporter: Inward facing PepTSt from Streptococcus thermophilus crystallized in space group P3121

(2017) Esben M. Quistgaard et al.   PLoS One

Proton movement and coupling in the POT family of peptide transporters

(2017) Joanne L. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Classification Systems of Secondary Active Transporters

(2017) Emelie Perland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses

(2017) Magalie Martineau et al.   Nature Communications

Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression

(2017) Emelie Perland et al.   Open Biology

Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE

(2017) Meng Ke et al.   PLoS Computational Biology

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression

(2017) Dillon M. Voss et al.   Scientific Reports

Proton-solute coupling mechanism of the maltose transporter from Saccharomyces cerevisiae

(2017) Ryan Henderson et al.   Scientific Reports

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

(2016) Daniel Martinez Molina et al.   Annual Review of Pharmacology and Toxicology

Inward open characterization of EmrD transporter with molecular dynamics simulation

(2016) Xianwei Tan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms

(2016) Y. D. Bhutia et al.   BIOCHEMICAL JOURNAL

Transporter oligomerization: form and function

(2016) Y. Alguel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

On the Temperature Dependence of Enzyme-Catalyzed Rates

(2016) Vickery L. Arcus et al.   BIOCHEMISTRY

The transport mechanism of the mitochondrial ADP/ATP carrier

(2016) Edmund R.S. Kunji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of an important motif that controls the activity and specificity of sugar transporters

(2016) Meng Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

(2016) RS Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

(2016) Richard C. Hresko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STP10encodes a high-affinity monosaccharide transporter and is induced under low-glucose conditions in pollen tubes of Arabidopsis

(2016) Theresa Rottmann et al.   JOURNAL OF EXPERIMENTAL BOTANY

A saposin-lipoprotein nanoparticle system for membrane proteins

(2016) Jens Frauenfeld et al.   NATURE METHODS

A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies

(2016) Francesca Magnani et al.   Nature Protocols

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Protons Regulate Vesicular Glutamate Transporters through an Allosteric Mechanism

(2016) Jacob Eriksen et al.   NEURON

Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis

(2016) Dana Yaffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a LacY–nanobody complex in a periplasmic-open conformation

(2016) Xin Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel cell-free high-throughput screening method for pharmacological tools targeting K+channels

(2016) Zhenwei Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

(2016) Khyati Kapoor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

(2016) Dong Deng et al.   PROTEIN SCIENCE

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pharmacological Targeting of the Hepcidin/Ferroportin Axis

(2016) Giada Sebastiani et al.   Frontiers in Pharmacology

pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases

(2016) Andre Bazzone et al.   PLoS One

Relocation of active site carboxylates in major facilitator superfamily multidrug transporter LmrP reveals plasticity in proton interactions

(2016) Asha V. Nair et al.   Scientific Reports

Structural Symmetry in Membrane Proteins

(2015) Lucy R. Forrest   Annual Review of Biophysics

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

Design and engineering of intracellular-metabolite-sensing/regulation gene circuits inSaccharomyces cerevisiae

(2015) Meng Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Role of electrostatic interactions for ligand recognition and specificity of peptide transporters

(2015) Rajendra Boggavarapu et al.   BMC BIOLOGY

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Substrate-bound structure of the E. coli multidrug resistance transporter MdfA

(2015) Jie Heng et al.   CELL RESEARCH

Insights into the inhibitory mechanisms of the regulatory protein IIAGlcon melibiose permease activity.

(2015) Parameswaran Hariharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Structure and mechanism of the mammalian fructose transporter GLUT5

(2015) Norimichi Nomura et al.   NATURE

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc

(2015) Parameswaran Hariharan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chemiosmotic mechanism of symport

(2015) H. Ronald Kaback   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy coupling mechanisms of MFS transporters

(2015) Xuejun C. Zhang et al.   PROTEIN SCIENCE

Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport

(2015) John H. Beale et al.   STRUCTURE

Gating Topology of the Proton-Coupled Oligopeptide Symporters

(2015) Philip W. Fowler et al.   STRUCTURE

The importance of ligands for G protein-coupled receptor stability

(2015) Xianjun Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK

(2015) Masahiro Fukuda et al.   Nature Communications

Structural basis for the facilitative diffusion mechanism by SemiSWEET transporter

(2015) Yongchan Lee et al.   Nature Communications

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

(2015) Reiya Taniguchi et al.   Nature Communications

Novel microscale approaches for easy, rapid determination of protein stability in academic and commercial settings

(2014) Crispin G. Alexander et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

When two turn into one: evolution of membrane transporters from half modules

(2014) Rebecca Keller et al.   BIOLOGICAL CHEMISTRY

Crystal structure of a bacterial homologue of SWEET transporters

(2014) Jing Wang et al.   CELL RESEARCH

Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

(2014) J. A. Lyons et al.   EMBO REPORTS

The Yeast Deletion Collection: A Decade of Functional Genomics

(2014) Guri Giaever et al.   GENETICS

Functionally Important Carboxyls in a Bacterial Homologue of the Vesicular Monoamine Transporter (VMAT)

(2014) Dana Yaffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Inhibitory Mechanisms of the Regulatory Protein IIAGlcon Melibiose Permease Activity

(2014) Parameswaran Hariharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

(2014) Josef Deutscher et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Structures of bacterial homologues of SWEET transporters in two distinct conformations

(2014) Yan Xu et al.   NATURE

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

(2014) Joanne L. Parker et al.   NATURE

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

(2014) Ji Sun et al.   NATURE

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2

(2014) Fatma Guettou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional architecture of MFS D-glucose transporters

(2014) M. G. Madej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the E. coli Peptide Transporter YbgH

(2014) Yan Zhao et al.   STRUCTURE

Structure-based mechanism for Na+/melibiose symport by MelB

(2014) Abdul S. Ethayathulla et al.   Nature Communications

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE

(2014) Goragot Wisedchaisri et al.   Nature Communications

Thermodynamic evidence for a dual transport mechanism in a POT peptide transporter

(2014) Joanne L Parker et al.   eLife

MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches

(2014) Sandra C. dos Santos et al.   Frontiers in Physiology

Beyond cellular detoxification: a plethora of physiological roles for MDR transporter homologs in plants

(2014) Estelle Remy et al.   Frontiers in Physiology

MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?

(2014) Catarina Costa et al.   Frontiers in Physiology

Change in Heat Capacity for Enzyme Catalysis Determines Temperature Dependence of Enzyme Catalyzed Rates

(2013) Joanne K. Hobbs et al.   ACS Chemical Biology

Common Folds and Transport Mechanisms of Secondary Active Transporters

(2013) Yigong Shi   Annual Review of Biophysics

New Insight into P-Glycoprotein as a Drug Target

(2013) Albert Breier et al.   Anti-Cancer Agents in Medicinal Chemistry

Radioligand Binding to Nanodisc-Reconstituted Membrane Transporters Assessed by the Scintillation Proximity Assay

(2013) Mahmoud L. Nasr et al.   BIOCHEMISTRY

Multidrug resistance protein MdtM adds to the repertoire of antiporters involved in alkaline pH homeostasis in Escherichia coli

(2013) Scarlett R Holdsworth et al.   BMC MICROBIOLOGY

Influence of lipids on protein-mediated transmembrane transport

(2013) Elizabeth J. Denning et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Drug transport via the intestinal peptide transporter PepT1

(2013) Matthias Brandsch   CURRENT OPINION IN PHARMACOLOGY

Structural insights into substrate recognition in proton-dependent oligopeptide transporters

(2013) Fatma Guettou et al.   EMBO REPORTS

Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

(2013) Lukas S. Stelzl et al.   JOURNAL OF MOLECULAR BIOLOGY

Solute carriers (SLCs) in cancer

(2013) Sara El-Gebali et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Crystal structure of a eukaryotic phosphate transporter

(2013) Bjørn P. Pedersen et al.   NATURE

Protonation drives the conformational switch in the multidrug transporter LmrP

(2013) Matthieu Masureel et al.   Nature Chemical Biology

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Optimizing plant transporter expression in Xenopus oocytes

(2013) Huimin Feng et al.   Plant Methods

Evolutionary mix-and-match with MFS transporters II

(2013) M. G. Madej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2

(2013) D. Yaffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of a glucose/H+ symporter and its mechanism of action

(2013) C. V. Iancu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

(2013) S. Doki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

(2013) Daohua Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural advances for the major facilitator superfamily (MFS) transporters

(2013) Nieng Yan   TRENDS IN BIOCHEMICAL SCIENCES

Structure and Mechanism of a Nitrate Transporter

(2013) Hanchi Yan et al.   Cell Reports

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

(2013) Mariafrancesca Scalise et al.   Pharmaceutics

Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: The mouse carnitine transporter OCTN3

(2012) Mariafrancesca Scalise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sided Functions of an Arginine–Agmatine Antiporter Oriented in Liposomes

(2012) Ming-Feng Tsai et al.   BIOCHEMISTRY

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

(2012) Thomas A. Hopf et al.   CELL

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

Alternating access mechanism in the POT family of oligopeptide transporters

(2012) Nicolae Solcan et al.   EMBO JOURNAL

The major facilitator superfamily (MFS) revisited

(2012) Vamsee S. Reddy et al.   FEBS Journal

Sequence Determinants of GLUT1-mediated Accelerated-exchange Transport

(2012) Sabrina S. Vollers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiparallel Dimers of the Small Multidrug Resistance Protein EmrE Are More Stable Than Parallel Dimers

(2012) Pilar Lloris-Garcerá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein

(2012) Nir Fluman et al.   MOLECULAR CELL

Overexpression of membrane proteins in mammalian cells for structural studies

(2012) Juni Andréll et al.   MOLECULAR MEMBRANE BIOLOGY

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

(2012) Daniel Harder et al.   Nature Protocols

Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets

(2012) Vera Miranda-Gonçalves et al.   NEURO-ONCOLOGY

GLUT1 deficiency: A glut of epilepsy phenotypes

(2012) I. E. Scheffer   NEUROLOGY

Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel

(2012) Uchenna O. Njiaju et al.   Pharmacogenetics and Genomics

Role of protons in sugar binding to LacY

(2012) I. Smirnova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulating the drug/proton antiport stoichiometry of the secondary multidrug transporter MdfA

(2012) O. Tirosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simulations of substrate transport in the multidrug transporter EmrD

(2012) Joseph Baker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Proton-Coupled Dynamics in Lactose Permease

(2012) Magnus Andersson et al.   STRUCTURE

A Fluorescence-Detection Size-Exclusion Chromatography-Based Thermostability Assay for Membrane Protein Precrystallization Screening

(2012) Motoyuki Hattori et al.   STRUCTURE

G117C MelB, a mutant melibiose permease with a changed conformational equilibrium

(2011) C. Ganea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

(2011) Toshinori Komatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

(2011) Zhanjun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Large Extracellular Loop of Organic Cation Transporter 1 Influences Substrate Affinity and Is Pivotal for Oligomerization

(2011) Thorsten Keller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitrate transceptor(s) in plants

(2011) A. Gojon et al.   JOURNAL OF EXPERIMENTAL BOTANY

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

Benchmarking Membrane Protein Detergent Stability for Improving Throughput of High-Resolution X-ray Structures

(2011) Yo Sonoda et al.   STRUCTURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2

(2010) Simon Newstead et al.   EMBO JOURNAL

A flexible cation binding site in the multidrug major facilitator superfamily transporter LmrP is associated with variable proton coupling

(2010) Theresia A. Schaedler et al.   FASEB JOURNAL

Tricks of the trade used to accelerate high-resolution structure determination of membrane proteins

(2010) Yo Sonoda et al.   FEBS LETTERS

Identification of a Key Residue Determining Substrate Affinity in the Yeast Glucose Transporter Hxt7

(2010) Toshiko Kasahara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Glimpse of Vesicular Monoamine Transporters

(2010) Shimon Schuldiner   JOURNAL OF NEUROCHEMISTRY

Vesicular monoamine transporters: Structure-function, pharmacology, and medicinal chemistry

(2010) Kandatege Wimalasena   MEDICINAL RESEARCH REVIEWS

The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species

(2010) P. J. Hoglund et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structure of a fucose transporter in an outward-open conformation

(2010) Shangyu Dang et al.   NATURE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Will the original glucose transporter isoform please stand up!

(2009) Anthony Carruthers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Identification of a key residue determining substrate affinity in the human glucose transporter GLUT1

(2009) Toshiko Kasahara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

NMR and EPR studies of membrane transporters

(2009) Ute A. Hellmich et al.   BIOLOGICAL CHEMISTRY

The expanding phenotype of GLUT1-deficiency syndrome

(2009) Knut Brockmann   BRAIN & DEVELOPMENT

CHL1 Functions as a Nitrate Sensor in Plants

(2009) Cheng-Hsun Ho et al.   CELL

Directed Evolution Reveals Hidden Properties of VMAT, a Neurotransmitter Transporter

(2009) Yael Gros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Promiscuous Conformational Switch in the Secondary Multidrug Transporter MdfA

(2009) Nir Fluman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Secondary Multidrug/Proton Antiporter MdfA Tolerates Displacements of an Essential Negatively Charged Side Chain

(2009) Nadejda Sigal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functioning and Evolutionary Significance of Nutrient Transceptors

(2009) J. M. Thevelein et al.   MOLECULAR BIOLOGY AND EVOLUTION

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Regulation of the fructose transporter GLUT5 in health and disease

(2008) Veronique Douard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bacterial multidrug transport through the lens of the major facilitator superfamily

(2008) Nir Fluman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

Functional Studies of the T295M Mutation Causing Glut1 Deficiency: Glucose Efflux Preferentially Affected by T295M

(2008) Dong Wang et al.   PEDIATRIC RESEARCH

Protonation and sugar binding to LacY

(2008) Irina N. Smirnova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microscale Fluorescent Thermal Stability Assay for Membrane Proteins

(2008) Alexander I. Alexandrov et al.   STRUCTURE