Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex

(2019) Renhong Yan et al.   NATURE

Volta Phase Plate Cryo-EM Structure of the Human Heterodimeric Amino Acid Transporter 4F2hc-LAT2

(2019) Jean-Marc Jeckelmann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1

(2018) Natesh Singh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters

(2018) Hüseyin Ilgü et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for amino acid transport by the CAT family of SLC7 transporters

(2018) Katharina E. J. Jungnickel et al.   Nature Communications

Structural analysis of glycoproteins: building N-linked glycans with Coot

(2018) Paul Emsley et al.   Acta Crystallographica Section D-Structural Biology

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

(2018) Pascal Häfliger et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)

(2018) Huan-Chieh Chien et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amino acid transporters revisited: New views in health and disease

(2018) Palanivel Kandasamy et al.   TRENDS IN BIOCHEMICAL SCIENCES

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

(2017) Elena Puris et al.   JOURNAL OF CONTROLLED RELEASE

Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

(2017) Ryuichi Ohgaki et al.   MOLECULAR AND CELLULAR BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol

(2017) David Dickens et al.   Scientific Reports

Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms

(2016) M. Palacin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia

(2016) Jeevisha Bajaj et al.   CANCER CELL

Specific transport of 3-fluoro-l-α-methyl-tyrosine by LAT1 explains its specificity to malignant tumors in imaging

(2016) Ling Wei et al.   CANCER SCIENCE

Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1

(2016) Shushi Nagamori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the molecular basis for substrate binding and specificity of the wild-type L-arginine/agmatine antiporter AdiC

(2016) Hüseyin Ilgü et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting L-type amino acid transporter 1 for anticancer therapy: clinical impact from diagnostics to therapeutics

(2015) Su-Eon Jin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Antitumor activity of an anti-CD98 antibody

(2015) Gregory M. Hayes et al.   INTERNATIONAL JOURNAL OF CANCER

Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

(2015) Takashi Muramatsu   JOURNAL OF BIOCHEMISTRY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Principles of cryo-EM single-particle image processing

(2015) Fred J. Sigworth   Microscopy

L-type amino-acid transporter 1 (LAT1): a therapeutic target supporting growth and survival of T-cell lymphoblastic lymphoma/T-cell acute lymphoblastic leukemia

(2014) C Rosilio et al.   LEUKEMIA

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

(2014) A. Rosell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion

(2012) Henna Ylikangas et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Transport of 3-Fluoro-L- -Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET

(2012) P. Wiriyasermkul et al.   JOURNAL OF NUCLEAR MEDICINE

Fabs Enable Single Particle cryoEM Studies of Small Proteins

(2012) Shenping Wu et al.   STRUCTURE

Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery

(2011) Lauri Peura et al.   MOLECULAR PHARMACEUTICS

Molecular basis of substrate-induced permeation by an amino acid antiporter

(2011) L. Kowalczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mechanism of substrate recognition and transport by an amino acid antiporter

(2010) Xiang Gao et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Structure of a prokaryotic virtual proton pump at 3.2 Å resolution

(2009) Yiling Fang et al.   NATURE

Unlocking the molecular secrets of sodium-coupled transporters

(2009) Harini Krishnamurthy et al.   NATURE

CD98hc facilitates B cell proliferation and adaptive humoral immunity

(2009) Joseph Cantor et al.   NATURE IMMUNOLOGY

Modulation of protein properties in living cells using nanobodies

(2009) Axel Kirchhofer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane reconstitution of ABC transporters and assays of translocator function

(2008) Eric R Geertsma et al.   Nature Protocols