Journal
MOLECULAR ASPECTS OF MEDICINE
Volume 34, Issue 2-3, Pages 121-138Publisher
ELSEVIER
DOI: 10.1016/j.mam.2012.07.001
Keywords
SLC2; GLUT; Membrane transport; Glucose transporters; Glucose homeostasis
Funding
- National Institutes of Health [R0143695]
- Diabetes Research and Training Center and Nutritional Sciences Center
- Digestive Disease Center at Washington University
- Swiss National Science Foundation [31003A-113525]
- Juvenile Diabetes Research Foudation Program [7-2005-1158]
- Integrated Project Eurodia [LSHM-CT-2006 518153]
- European Community
- Swiss National Science Foundation through the National Center of Competence in Research (NCCR) TransCure, University of Bern, Switzerland
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GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of similar to 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members. (C) 2012 Elsevier Ltd. All rights reserved.
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