Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

(2016) S. Y. C. Choi et al.   CLINICAL CANCER RESEARCH

In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1)

(2016) Na-Young Lee et al.   PHARMACEUTICAL RESEARCH

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II

(2015) Sina Ibne Noor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer

(2015) Isabel Valença et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

(2015) Franziska Baenke et al.   JOURNAL OF PATHOLOGY

Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria

(2015) N. Dhayat et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

Changes in lactate content and monocarboxylate transporter 2 expression in Aβ25-35-treated rat model of Alzheimer’s disease

(2015) Weitian Lu et al.   NEUROLOGICAL SCIENCES

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

(2015) Nelma Pertega-Gomes et al.   Oncotarget

The genetic variation in Monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility

(2014) Suman Lee et al.   ASIAN JOURNAL OF ANDROLOGY

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

(2014) B. M. Bola et al.   MOLECULAR CANCER THERAPEUTICS

MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies

(2014) GuemHee Baek et al.   Cell Reports

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

(2013) Nihed Draoui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome

(2013) P. Fisel et al.   CLINICAL CANCER RESEARCH

Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency

(2013) Julia Müller et al.   ENDOCRINOLOGY

The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter

(2013) Jeannette Abplanalp et al.   HUMAN MOLECULAR GENETICS

Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-enzymatically to Enhance Activity of Monocarboxylate Transporters

(2013) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

(2013) Sylvain Lengacher et al.   PLoS One

A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

(2013) Akiyoshi Nakayama et al.   Human Cell

Using the “reverse Warburg effect” to identify high-risk breast cancer patients

(2012) Agnieszka K. Witkiewicz et al.   CELL CYCLE

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting

(2012) S. E. Hugo et al.   GENES & DEVELOPMENT

Role of monocarboxylate transporters in human cancers: state of the art

(2012) Céline Pinheiro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women

(2012) Rocío Cupeiro et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

(2012) Kivanç Birsoy et al.   NATURE GENETICS

Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer

(2012) Nelma Pértega-Gomes et al.   PROSTATE

Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1

(2012) Clara Påhlman et al.   TRANSPLANT INTERNATIONAL

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II

(2011) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in metabolism between adeno- and squamous cell non-small cell lung carcinomas: Spatial distribution and prognostic value of GLUT1 and MCT4

(2011) Tineke W.H. Meijer et al.   LUNG CANCER

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice

(2011) Yingchang Lu et al.   PHYSIOLOGICAL GENOMICS

Gene Expression Profile Change and Associated Physiological and Pathological Effects in Mouse Liver Induced by Fasting and Refeeding

(2011) Fang Zhang et al.   PLoS One

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

(2010) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44

(2010) Céline Pinheiro et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle

(2009) Marieangela C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal 3',3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan-Herndon-Dudley Syndrome

(2009) E. K. Wirth et al.   JOURNAL OF NEUROSCIENCE

Mutation of Solute Carrier SLC16A12 Associates with a Syndrome Combining Juvenile Cataract with Microcornea and Renal Glucosuria

(2008) Barbara Kloeckener-Gruissem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice

(2008) Lauren L. Daniele et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier

(2008) Lori M. Roberts et al.   ENDOCRINOLOGY