Elevator-type mechanisms of membrane transport

Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

(2020) Valentina Arkhipova et al.   Nature Communications

Membrane mediated toppling mechanism of the folate energy coupling factor transporter

(2020) Ignacio Faustino et al.   Nature Communications

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

Models to determine the kinetic mechanisms of ion-coupled transporters

(2019) Juke S. Lolkema et al.   JOURNAL OF GENERAL PHYSIOLOGY

Binding and transport of D-aspartate by the glutamate transporter homolog GltTk

(2019) Valentina Arkhipova et al.   eLife

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM

(2019) Valeria Kalienkova et al.   eLife

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2

(2019) Alisa A. Garaeva et al.   Nature Communications

Kinetic Models of Secondary Active Transporters

(2019) Burtscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardiolipin is an Optimal Phospholipid for the Assembly, Stability, and Proper Functionality of the Dimeric Form of NhaA Na+/H+ Antiporter

(2019) Abraham Rimon et al.   Scientific Reports

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

(2019) Xiaodi Yu et al.   eLife

Large-scale state-dependent membrane remodeling by a transporter protein

(2019) Wenchang Zhou et al.   eLife

Structural biology of solute carrier (SLC) membrane transport proteins

(2018) Xiaoyun Bai et al.   MOLECULAR MEMBRANE BIOLOGY

Solution structure and elevator mechanism of the membrane electron transporter CcdA

(2018) Yunpeng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the human neutral amino acid transporter ASCT2

(2018) Alisa A. Garaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of an EIIC sugar transporter trapped in an inward-facing conformation

(2018) Zhenning Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5

(2018) Amanda J Scopelliti et al.   Nature Communications

Solution structure and elevator mechanism of the membrane electron transporter CcdA

(2018) Yunpeng Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the human neutral amino acid transporter ASCT2

(2018) Alisa A. Garaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

(2018) Joana A Santos et al.   eLife

Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism

(2018) Ping Luo et al.   Cell Discovery

Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM

(2018) S. Rempel et al.   Nature Communications

Kinetic mechanism of coupled binding in sodium-aspartate symporter GltPh

(2018) SeCheol Oh et al.   eLife

Energy-Coupling Factor–Type ATP-Binding Cassette Transporters

(2018) S. Rempel et al.   Annual Review of Biochemistry

Analysis of the quality of crystallographic data and the limitations of structural models

(2017) Valentina Arkhipova et al.   JOURNAL OF GENERAL PHYSIOLOGY

Asymmetry of inverted-topology repeats in the AE1 anion exchanger suggests an elevator-like mechanism

(2017) Emel Ficici et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

Visualizing multistep elevator-like transitions of a nucleoside transporter

(2017) Marscha Hirschi et al.   NATURE

Direct visualization of glutamate transporter elevator mechanism by high-speed AFM

(2017) Yi Ruan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the elevator-like mechanism of the sodium/citrate symporter CitS

(2017) Ji Won Kim et al.   Scientific Reports

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin

(2016) Nathan K. Karpowich et al.   JOURNAL OF MOLECULAR BIOLOGY

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

(2016) Christopher Mulligan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

(2016) Mathieu Coincon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of Bor1 supports an elevator transport mechanism for SLC4 anion exchangers

(2016) Bryan H. Thurtle-Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the SLC4 transporter Bor1p in an inward-facing conformation

(2016) Nicolas Coudray et al.   PROTEIN SCIENCE

The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport

(2016) Jason G. McCoy et al.   STRUCTURE

Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk

(2016) Albert Guskov et al.   Nature Communications

Structural insight in the toppling mechanism of an energy-coupling factor transporter

(2016) Lotteke J. Y. M. Swier et al.   Nature Communications

Structure of eukaryotic purine/H+ symporter UapA suggests a role for homodimerization in transport activity

(2016) Yilmaz Alguel et al.   Nature Communications

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism

(2016) Christopher Mulligan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures reveal the molecular basis of ion translocation in sodium/proton antiporters

(2016) Mathieu Coincon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Symmetry in Membrane Proteins

(2015) Lucy R. Forrest   Annual Review of Biophysics

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine

(2015) Lotteke J. Y. M. Swier et al.   CHEMBIOCHEM

Transport Rates of a Glutamate Transporter Homologue Are Influenced by the Lipid Bilayer

(2015) Benjamin C. McIlwain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Affinity and Slow Na+Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh

(2015) Inga Hänelt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond non-integer Hill coefficients: A novel approach to analyzing binding data, applied to Na+-driven transporters

(2015) Silvia Ravera et al.   JOURNAL OF GENERAL PHYSIOLOGY

Family resemblances: A common fold for some dimeric ion-coupled secondary transporters

(2015) Ariela Vergara-Jaque et al.   JOURNAL OF GENERAL PHYSIOLOGY

Transport domain unlocking sets the uptake rate of an aspartate transporter

(2015) Nurunisa Akyuz et al.   NATURE

Structure and mechanism of the mammalian fructose transporter GLUT5

(2015) Norimichi Nomura et al.   NATURE

Crystal structure of a phosphorylation-coupled vitamin C transporter

(2015) Ping Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of the anion exchanger domain of human erythrocyte band 3

(2015) T. Arakawa et al.   SCIENCE

Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters

(2015) Qin Zhao et al.   Nature Communications

Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology

(2015) Jani Reddy Bolla et al.   Nature Communications

Crystal structure of a phosphorylation-coupled vitamin C transporter

(2015) Ping Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family

(2015) Eric R Geertsma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps

(2015) Chih-Chia Su et al.   Cell Reports

Mechanism of Na+-dependent citrate transport from the structure of an asymmetrical CitS dimer

(2015) David Wöhlert et al.   eLife

Diversity in ABC transporters: Type I, II and III importers

(2014) Austin J. Rice et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Crystal structure of the sodium–proton antiporter NhaA dimer and new mechanistic insights

(2014) Chiara Lee et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters

(2014) Minhua Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters

(2014) Zachary Lee Johnson et al.   eLife

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

(2014) Grégory Verdon et al.   eLife

Structure and substrate ion binding in the sodium/proton antiporter PaNhaP

(2014) David Wöhlert et al.   eLife

Structure and transport mechanism of the sodium/proton antiporter MjNhaP1

(2014) Cristina Paulino et al.   eLife

Common Folds and Transport Mechanisms of Secondary Active Transporters

(2013) Yigong Shi   Annual Review of Biophysics

Planar substrate-binding site dictates the specificity of ECF-type nickel/cobalt transporters

(2013) You Yu et al.   CELL RESEARCH

A two-domain elevator mechanism for sodium/proton antiport

(2013) Chiara Lee et al.   NATURE

Transport dynamics in a glutamate transporter homologue

(2013) Nurunisa Akyuz et al.   NATURE

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

(2013) Guus B. Erkens et al.   NATURE

Structural basis of the alternating-access mechanism in a bile acid transporter

(2013) Xiaoming Zhou et al.   NATURE

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

(2013) Ke Xu et al.   NATURE

Structure of a bacterial energy-coupling factor transporter

(2013) Tingliang Wang et al.   NATURE

Crystal structure of a substrate-free aspartate transporter

(2013) Sonja Jensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Binding thermodynamics of a glutamate transporter homolog

(2013) Nicolas Reyes et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Induced fit substrate binding to an archeal glutamate transporter homologue

(2013) D. Ewers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Substrate-Induced Conformational Changes of the Secondary Citrate/Sodium Symporter CitS Revealed by Electron Crystallography

(2013) Fabian Kebbel et al.   STRUCTURE

Structural Intermediates in a Model of the Substrate Translocation Path of the Bacterial Glutamate Transporter Homologue GltPh

(2012) Sebastian Stolzenberg et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å

(2012) Zachary Lee Johnson et al.   NATURE

Structure and mechanism of a bacterial sodium-dependent dicarboxylate transporter

(2012) Romina Mancusso et al.   NATURE

Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog

(2012) Grégory Verdon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural divergence of paralogous S components from ECF-type ABC transporters

(2012) R. P.- A. Berntsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-Type ATPases

(2011) Michael G. Palmgren et al.   Annual Review of Biophysics

Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT

(2011) Nien-Jen Hu et al.   NATURE

Structure and mechanism of the uracil transporter UraA

(2011) Feiran Lu et al.   NATURE

Crystal structure of a phosphorylation-coupled saccharide transporter

(2011) Yu Cao et al.   NATURE

The structural basis of modularity in ECF-type ABC transporters

(2011) Guus B Erkens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Large collective motions regulate the functional properties of glutamate transporter trimers

(2011) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mechanism of substrate release by the aspartate transporter GltPh: insights from simulations

(2010) Jason DeChancie et al.   Molecular BioSystems

Structure and mechanism of the S component of a bacterial ECF transporter

(2010) Peng Zhang et al.   NATURE

Transport mechanism of a bacterial homologue of glutamate transporters

(2009) Nicolas Reyes et al.   NATURE

Inward-facing conformation of glutamate transporters as revealed by their inverted-topology structural repeats

(2009) T. J. Crisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformations of NhaA, the Na/H Exchanger from Escherichia coli, in the pH-Activated and Ion-Translocating States

(2008) Matthias Appel et al.   JOURNAL OF MOLECULAR BIOLOGY