Monocarboxylate Transporters (SLC16): Function, Regulation, and Role in Health and Disease

Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells

(2019) Xiaowen Guan et al.   AAPS Journal

Ethanol Activates Immune Response In Lymphoblastoid Cells

(2019) Jeanette N. McClintick et al.   ALCOHOL

The Monocarboxylate Transporter SLC16A6 Regulates Adult Length in Zebrafish and Is Associated With Height in Humans

(2019) Santhosh Karanth et al.   Frontiers in Physiology

Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes

(2019) Yongxu Zhao et al.   Cell Reports

Shared genes between Alzheimer’s disease and ischemic stroke

(2019) Chang-Juan Wei et al.   CNS Neuroscience & Therapeutics

A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells

(2019) Mam Y. Mboge et al.   BIOCHEMICAL JOURNAL

Catalytically‐inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT 1

(2019) Ashok Aspatwar et al.   FEBS Open Bio

Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas

(2019) Wey-Ran Lin et al.   EBioMedicine

TNFα-Induced Expression of Transport Protein Genes in HUVEC Cells Is Associated with Enhanced Expression of Transcription Factor Genes RELB and NFKB2 of the Non-Canonical NF-κB Pathway

(2018) E. N. Knyazev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

(2018) Pascale Fisel et al.   CTS-Clinical and Translational Science

Genetic variations in the monocarboxylate transporter genes ( SLC16A1 , SLC16A3 , and SLC16A11 ) in the Japanese population

(2018) Yuki Kimura et al.   Drug Metabolism and Pharmacokinetics

An unexpected world population variation of MCT1 polymorphism 1470T > A involved in lactate transport

(2018) Federico Onali et al.   European Journal of Sport Science

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

(2018) Jiaqi Liu et al.   HUMAN GENETICS

The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells

(2018) Samantha Ames et al.   Oncotarget

Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10)

(2018) David S. Sharlin et al.   Scientific Reports

A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

(2018) Sina Ibne Noor et al.   eLife

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

(2018) Bianca D. van Groen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Dysregulation of mucosal membrane transporters and drug metabolizing enzymes in ulcerative colitis

(2018) Pascal Erdmann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer

(2018) Sara Bisetto et al.   Frontiers in Oncology

Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70

(2018) Linda S. Forero-Quintero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: in vivo insights from MCT1 haploinsufficient mice

(2017) Benjamin Chatel et al.   FASEB JOURNAL

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

(2017) Richard A. Noble et al.   HAEMATOLOGICA

Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147

(2017) Andrina Stäubli et al.   HUMAN MOLECULAR GENETICS

Clinical and Molecular Characteristics of SLC16A2 (MCT8) Mutations in Three Families with the Allan-Herndon-Dudley Syndrome

(2017) Francesca Novara et al.   HUMAN MUTATION

Sex Hormones Regulate Rat Hepatic Monocarboxylate Transporter Expression and Membrane Trafficking

(2017) Jieyun Cao et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6

(2017) Robert S. Jones et al.   MOLECULAR PHARMACEUTICS

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

(2017) Kerstin Römermann et al.   NEUROPHARMACOLOGY

Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells

(2017) K Diehl et al.   ONCOGENE

Associations of common variants in the SLC16A11 , TCF7L2, and ABCA1 genes with pediatric-onset type 2 diabetes and related glycemic traits in families: A case-control and case-parent trio study

(2017) América L Miranda-Lora et al.   PEDIATRIC DIABETES

RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with disease progression in dengue patients

(2017) Arup Banerjee et al.   Translational Research

MiR-1 suppresses tumor cell proliferation in colorectal cancer by inhibition of Smad3-mediated tumor glycolysis

(2017) Wanfu Xu et al.   Cell Death & Disease

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt’s lymphoma anti-tumor activity

(2017) Nicola J. Curtis et al.   Oncotarget

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

(2017) Richard A. Noble et al.   HAEMATOLOGICA

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer

(2017) Britt I. Drögemöller et al.   JAMA Oncology

The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters

(2016) B. Nancolas et al.   BIOCHEMICAL JOURNAL

Monocarboxylate transporters in the brain and in cancer

(2016) Jhudit Pérez-Escuredo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Histological characterization of orphan transporter MCT14 (SLC16A14) shows abundant expression in mouse CNS and kidney

(2016) Sahar Roshanbin et al.   BMC NEUROSCIENCE

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

(2016) RS Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase

(2016) J. Patrizia Stohn et al.   ENDOCRINOLOGY

Integration of a ‘proton antenna’ facilitates transport activity of the monocarboxylate transporter MCT4

(2016) Sina Ibne Noor et al.   FEBS Journal

Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10*

(2016) Jörg Johannes et al.   MOLECULAR ENDOCRINOLOGY

Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism

(2016) Kyung Eun Kim et al.   Scientific Reports

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics

(2015) Miriam G. Mooij et al.   CLINICAL PHARMACOKINETICS

Embryonic stem cell-derived pancreatic endoderm transplant with MCT1-suppressing miR-495 attenuates type II diabetes in mice

(2015) Dong Liang et al.   ENDOCRINE JOURNAL

Intestinal absorption mechanisms of MTBH, a novel hesperetin derivative, in Caco-2 cells, and potential involvement of monocarboxylate transporter 1 and multidrug resistance protein 2

(2015) Chenlin Shen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II

(2015) Sina Ibne Noor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters

(2015) Ibtissam Marchiq et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival

(2015) Franziska Baenke et al.   JOURNAL OF PATHOLOGY

Mutation in the Monocarboxylate Transporter 12 Gene Affects Guanidinoacetate Excretion but Does Not Cause Glucosuria

(2015) N. Dhayat et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis

(2015) Kuei-Yang Hsiao et al.   MOLECULAR HUMAN REPRODUCTION

MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma

(2015) Pascale Fisel et al.   Oncotarget

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

(2015) Somayeh Jamali et al.   Scientific Reports

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory

(2015) Monika Tadi et al.   PLoS One

Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease

(2014) April D. Lake et al.   AMINO ACIDS

High Monocarboxylate Transporter 4 Protein Expression in Stromal Cells Predicts Adverse Survival in Gastric Cancer

(2014) Ping Yan et al.   Asian Pacific Journal of Cancer Prevention

Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia

(2014) Chao Chen et al.   BIPOLAR DISORDERS

Role of Monocarboxylate Transporters in Drug Delivery to the Brain

(2014) Nisha Vijay et al.   CURRENT PHARMACEUTICAL DESIGN

Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis

(2014) Steffen Mayerl et al.   JOURNAL OF CLINICAL INVESTIGATION

Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis

(2013) J. R. Doherty et al.   CANCER RESEARCH

Control of Sertoli cell metabolism by sex steroid hormones is mediated through modulation in glycolysis-related transporters and enzymes

(2013) Ana D. Martins et al.   CELL AND TISSUE RESEARCH

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

DNA Methylation of the SLC16A3 Promoter Regulates Expression of the Human Lactate Transporter MCT4 in Renal Cancer with Consequences for Clinical Outcome

(2013) P. Fisel et al.   CLINICAL CANCER RESEARCH

Tissue-Specific Alterations in Thyroid Hormone Homeostasis in Combined Mct10 and Mct8 Deficiency

(2013) Julia Müller et al.   ENDOCRINOLOGY

Overexpression of miR-10a and miR-375 and downregulation of YAP1 in medullary thyroid carcinoma

(2013) Jena Hudson et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel

(2013) Mine S. Cicek et al.   HUMAN MOLECULAR GENETICS

The cataract and glucosuria associated monocarboxylate transporter MCT12 is a new creatine transporter

(2013) Jeannette Abplanalp et al.   HUMAN MOLECULAR GENETICS

Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-enzymatically to Enhance Activity of Monocarboxylate Transporters

(2013) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of AMPK activation on monocarboxylate transporter (MCT)1 and MCT4 in denervated muscle

(2013) Yu Kitaoka et al.   Journal of Physiological Sciences

Possible involvement of AMPK in acute exercise-induced expression of monocarboxylate transporters MCT1 and MCT4 mRNA in fast-twitch skeletal muscle

(2013) Masaki Takimoto et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The SLC16 gene family – Structure, role and regulation in health and disease

(2013) Andrew P. Halestrap   MOLECULAR ASPECTS OF MEDICINE

ATP5H/KCTD2 locus is associated with Alzheimer's disease risk

(2013) M Boada et al.   MOLECULAR PSYCHIATRY

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico

(2013)   NATURE

The Neuroplastin Adhesion Molecules Are Accessory Proteins That Chaperone the Monocarboxylate Transporter MCT2 to the Neuronal Cell Surface

(2013) Marieangela C. Wilson et al.   PLoS One

Resistance to Diet-Induced Obesity and Associated Metabolic Perturbations in Haploinsufficient Monocarboxylate Transporter 1 Mice

(2013) Sylvain Lengacher et al.   PLoS One

Thyroid hormone transporters and deiodinases in the developing human hypothalamus

(2012) Edith C H Friesema et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting

(2012) S. E. Hugo et al.   GENES & DEVELOPMENT

Regulation of human monocarboxylate transporter 4 in skeletal muscle cells: The role of protein kinase C (PKC)

(2012) Katsuya Narumi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of monocarboxylate transporters in human cancers: state of the art

(2012) Céline Pinheiro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Endothelial Cell-Derived Nitric Oxide Enhances Aerobic Glycolysis in Astrocytes via HIF-1 -Mediated Target Gene Activation

(2012) B. Brix et al.   JOURNAL OF NEUROSCIENCE

T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control

(2012) Luca Mariotta et al.   JOURNAL OF PHYSIOLOGY-LONDON

Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women

(2012) Rocío Cupeiro et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions

(2012) Kiminobu Sugito et al.   PEDIATRIC BLOOD & CANCER

Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer

(2012) Nelma Pértega-Gomes et al.   PROSTATE

Effect of growth on monocarboxylate transporters and indicators of energy metabolism in the gluteus medius muscle of Thoroughbreds

(2011) Yu Kitaoka et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Metabolic modulation induced by oestradiol and DHT in immature rat Sertoli cells culturedin vitro

(2011) Luís Rato et al.   BIOSCIENCE REPORTS

Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments

(2011) N. Draoui et al.   Disease Models & Mechanisms

The monocarboxylate transporter family-Structure and functional characterization

(2011) Andrew P. Halestrap   IUBMB LIFE

The monocarboxylate transporter family-Role and regulation

(2011) Andrew P. Halestrap et al.   IUBMB LIFE

Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II

(2011) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocarboxylate Transporter 2 and Stroke Severity in a Rodent Model of Sleep Apnea

(2011) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Quantitative Membrane Protein Expression at the Blood–Brain Barrier of Adult and Younger Cynomolgus Monkeys

(2011) Katsuaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle

(2011) Yu Kitaoka et al.   Journal of Physiological Sciences

miR-29a and miR-29b Contribute to Pancreatic  -Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

(2011) T. J. Pullen et al.   MOLECULAR AND CELLULAR BIOLOGY

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein

(2010) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Expression of Monocarboxylate Transporters 1, 2, and 4 in Human Tumours and Their Association with CD147 and CD44

(2010) Céline Pinheiro et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion

(2010) Caterina Di Cosmo et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonenzymatic Augmentation of Lactate Transport via Monocarboxylate Transporter Isoform 4 by Carbonic Anhydrase II

(2010) Holger M. Becker et al.   JOURNAL OF MEMBRANE BIOLOGY

AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle

(2010) Ayako Furugen et al.   LIFE SCIENCES

Monocarboxylate transporter 1 and CD147 are up-regulated by natural and synthetic peroxisome proliferator-activated receptor α agonists in livers of rodents and pigs

(2010) Bettina König et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Basolateral Sorting Signals Regulating Tissue-Specific Polarity of Heteromeric Monocarboxylate Transporters in Epithelia

(2010) John J. Castorino et al.   TRAFFIC

miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1

(2009) Kay Ka Wai Li et al.   HUMAN PATHOLOGY

Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle

(2009) Marieangela C. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal 3',3,5-Triiodothyronine (T3) Uptake and Behavioral Phenotype of Mice Deficient in Mct8, the Neuronal T3 Transporter Mutated in Allan-Herndon-Dudley Syndrome

(2009) E. K. Wirth et al.   JOURNAL OF NEUROSCIENCE

Overview of the Proton-coupled MCT (SLC16A) Family of Transporters: Characterization, Function and Role in the Transport of the Drug of Abuse γ-Hydroxybutyric Acid

(2008) Marilyn E. Morris et al.   AAPS Journal

Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer

(2008) Vadivel Ganapathy et al.   AAPS Journal

Mutation of Solute Carrier SLC16A12 Associates with a Syndrome Combining Juvenile Cataract with Microcornea and Renal Glucosuria

(2008) Barbara Kloeckener-Gruissem et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice

(2008) Lauren L. Daniele et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2

(2008) Seema Saksena et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Monocarboxylate transporter (MCT)-1 is up-regulated by PPARα

(2008) Bettina König et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Tissue-specific mRNA Expression Profiles of Human Solute Carrier Transporter Superfamilies

(2008) Masuhiro Nishimura et al.   Drug Metabolism and Pharmacokinetics

Expression of the Thyroid Hormone Transporters Monocarboxylate Transporter-8 (SLC16A2) and Organic Ion Transporter-14 (SLCO1C1) at the Blood-Brain Barrier

(2008) Lori M. Roberts et al.   ENDOCRINOLOGY

Nonenzymatic Proton Handling by Carbonic Anhydrase II during H+-Lactate Cotransport via Monocarboxylate Transporter 1

(2008) Holger M. Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA interference screen for human genes associated with West Nile virus infection

(2008) Manoj N. Krishnan et al.   NATURE

Regulation of monocarboxylate transporter 1 (MCT1) promoter by butyrate in human intestinal epithelial cells: Involvement of NF-κB pathway

(2007) Alip Borthakur et al.   JOURNAL OF CELLULAR BIOCHEMISTRY