Pharmacological Targeting of the Hepcidin/Ferroportin Axis

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Hepcidin regulation in the anemia of inflammation

(2016) Chia-Yu Wang et al.   CURRENT OPINION IN HEMATOLOGY

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels

(2016) S. Kovac et al.   HAEMATOLOGICA

Haemochromatosis

(2016) Lawrie W Powell et al.   LANCET

Iron and the liver

(2016) Antonello Pietrangelo   LIVER INTERNATIONAL

Hepcidin

(2016) Jing Liu et al.   MEDICINE

Anti-hemojuvelin antibody corrects anemia caused by inappropriately high hepcidin levels

(2016) S. Kovac et al.   HAEMATOLOGICA

High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin

(2016) Michela Asperti et al.   Frontiers in Pharmacology

Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation

(2015) Preethne Böser et al.   AAPS Journal

Hepatic Hepcidin Protects against Polymicrobial Sepsis in Mice by Regulating Host Iron Status

(2015) CongLi Zeng et al.   ANESTHESIOLOGY

Small cyclic agonists of iron regulatory hormone hepcidin

(2015) Kristine Chua et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

(2015) C. Guida et al.   BLOOD

Ineffective erythropoiesis and regulation of iron status in iron loading anaemias

(2015) Clara Camaschella et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer

(2015) Lia Tesfay et al.   CANCER RESEARCH

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

(2015) João Arezes et al.   Cell Host & Microbe

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Analysis of Inflammatory and Anemia-Related Biomarkers in a Randomized, Double-Blind, Placebo-Controlled Study of Siltuximab (Anti-IL6 Monoclonal Antibody) in Patients With Multicentric Castleman Disease

(2015) C. Casper et al.   CLINICAL CANCER RESEARCH

New insights into iron regulation and erythropoiesis

(2015) Airie Kim et al.   CURRENT OPINION IN HEMATOLOGY

Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin

(2015) Antonello Pietrangelo   GASTROENTEROLOGY

Progesterone receptor membrane component-1 regulates hepcidin biosynthesis

(2015) Xiang Li et al.   JOURNAL OF CLINICAL INVESTIGATION

A holistic approach to targeting disease with polymeric nanoparticles

(2015) Christopher J. Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

The iron-regulatory hormone hepcidin: A possible therapeutic target?

(2015) Luc Rochette et al.   PHARMACOLOGY & THERAPEUTICS

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anemia of Chronic Disorders: New Diagnostic Tools and New Treatment Strategies

(2015) Guenter Weiss   SEMINARS IN HEMATOLOGY

Modulation of hepcidin to treat iron deregulation: potential clinical applications

(2015) Nicole L. Blanchette et al.   Expert Review of Hematology

Oversulfated heparins with low anticoagulant activity are strong and fast inhibitors of hepcidin expression in vitro and in vivo

(2014) Maura Poli et al.   BIOCHEMICAL PHARMACOLOGY

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling

(2014) K. Mleczko-Sanecka et al.   BLOOD

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

(2014) L. T. van Eijk et al.   BLOOD

Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo

(2014) M. Poli et al.   BLOOD

A chemical screen identifies small molecules that regulate hepcidin expression

(2014) Vera Gaun et al.   BLOOD CELLS MOLECULES AND DISEASES

Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation

(2014) C. Mayeur et al.   HAEMATOLOGICA

Iron-Refractory Iron Deficiency Anemia (IRIDA)

(2014) Matthew M. Heeney et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Modulation of Hepcidin as Therapy for Primary and Secondary Iron Overload Disorders

(2014) Paul J. Schmidt et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The pathophysiology and pharmacology of hepcidin

(2014) Piotr Ruchala et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hepcidin antagonists for potential treatments of disorders with hepcidin excess

(2014) Maura Poli et al.   Frontiers in Pharmacology

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

(2013) Wen Guo et al.   AGING CELL

A fully human anti-hepcidin antibody modulates iron metabolism in both mice and nonhuman primates

(2013) K. S. Cooke et al.   BLOOD

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

(2013) F. Schwoebel et al.   BLOOD

The small molecule, genistein, increases hepcidin expression in human hepatocytes

(2013) Aileen W. Zhen et al.   HEPATOLOGY

Testosterone perturbs systemic iron balance through activation of epidermal growth factor receptor signaling in the liver and repression of hepcidin

(2013) Chloé Latour et al.   HEPATOLOGY

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

(2013) Shuling Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver as a target for oligonucleotide therapeutics

(2013) Alfica Sehgal et al.   JOURNAL OF HEPATOLOGY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Suppression of Iron-Regulatory Hepcidin by Vitamin D

(2013) J. Bacchetta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats

(2013) Chia Chi Sun et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Effects of subcutaneous and intravenous golimumab on inflammatory biomarkers in patients with rheumatoid arthritis: results of a phase 1, randomized, open-label trial

(2013) Mittie K. Doyle et al.   RHEUMATOLOGY

Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients

(2013) Soken-Nakazawa J Song et al.   ARTHRITIS RESEARCH & THERAPY

Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis

(2013) John D Isaacs et al.   ARTHRITIS RESEARCH & THERAPY

Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis

(2012) E. Ramos et al.   BLOOD

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine  -thalassemia intermedia

(2012) P. J. Schmidt et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

17β-Estradiol Inhibits Iron Hormone Hepcidin Through an Estrogen Responsive Element Half-Site

(2012) Qing Yang et al.   ENDOCRINOLOGY

Hepcidin is a Potential Regulator of Iron Status in Chronic Kidney Disease

(2012) Ken Tsuchiya et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Pharmacological Suppression of Hepcidin Increases Macrophage Cholesterol Efflux and Reduces Foam Cell Formation and Atherosclerosis

(2011) Omar Saeed et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

 -thalassemia: a model for elucidating the dynamic regulation of ineffective erythropoiesis and iron metabolism

(2011) Y. Ginzburg et al.   BLOOD

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

(2011) T. S. Perlstein et al.   BLOOD

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

(2011) K. E. Finberg et al.   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

(2011) A. U. Steinbicker et al.   BLOOD

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice

(2011) Giada Sebastiani et al.   Metallomics

Host-mediated regulation of superinfection in malaria

(2011) Silvia Portugal et al.   NATURE MEDICINE

Investigation of a Researcher's Death Due to Septicemic Plague

(2011) Karen M. Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

AG490: An inhibitor of hepcidin expressionin vivo

(2011) Shu-Ping Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo

(2010) M. Poli et al.   BLOOD

Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease

(2010) S.-N. J. Song et al.   BLOOD

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

(2010) Elena Corradini et al.   GASTROENTEROLOGY

Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells

(2010) J.H. Boergermann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

(2010) Sara Gardenghi et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroportin disease: A systematic meta-analysis of clinical and molecular findings

(2010) Roman Mayr et al.   JOURNAL OF HEPATOLOGY

Natural and synthetic STAT3 inhibitors reduce hepcidin expression in differentiated mouse hepatocytes expressing the active phosphorylated STAT3 form

(2010) Nadia Fatih et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Iron-Deficiency Anemia in Castleman Disease: Implication of the Interleukin 6/Hepcidin Pathway

(2010) J.-B. Arlet et al.   PEDIATRICS

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production

(2009) Misato Hashizume et al.   RHEUMATOLOGY INTERNATIONAL

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

(2008) Y. Jiao et al.   BLOOD