Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics

Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris — functional and kinetic asymmetry revealed in proteoliposomes

(2013) Piero Pingitore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of mitochondrial carnitine/acylcarnitine transporter by H2O2: Molecular mechanism and possible implication in pathophysiology

(2013) Annamaria Tonazzi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Transporters in Drug Development and Clinical Pharmacology

(2013) K M Giacomini et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Emerging Transporters of Clinical Importance: An Update From the International Transporter Consortium

(2013) K M Hillgren et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans

(2013) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis

(2013) Pingfang Song et al.   JOURNAL OF NEUROCHEMISTRY

Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors

(2013) Rongbao Zhao et al.   MOLECULAR ASPECTS OF MEDICINE

The acetyl-CoA transporter family SLC33

(2013) Yoshio Hirabayashi et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC1 high-affinity glutamate and neutral amino acid transporter family

(2013) Yoshikatsu Kanai et al.   MOLECULAR ASPECTS OF MEDICINE

Solute carriers as drug targets: Current use, clinical trials and prospective

(2013) Mathias Rask-Andersen et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

SLC27 fatty acid transport proteins

(2013) Courtney M. Anderson et al.   MOLECULAR ASPECTS OF MEDICINE

Phosphate transporters of the SLC20 and SLC34 families

(2013) Ian C. Forster et al.   MOLECULAR ASPECTS OF MEDICINE

SLC18: Vesicular neurotransmitter transporters for monoamines and acetylcholine

(2013) Hakeem O. Lawal et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC3 and SLC7 families of amino acid transporters

(2013) Dimitrios Fotiadis et al.   MOLECULAR ASPECTS OF MEDICINE

Novel riboflavin transporter family RFVT/SLC52: Identification, nomenclature, functional characterization and genetic diseases of RFVT/SLC52

(2013) Atsushi Yonezawa et al.   MOLECULAR ASPECTS OF MEDICINE

Glucose transport families SLC5 and SLC50

(2013) Ernest M. Wright   MOLECULAR ASPECTS OF MEDICINE

Crystal structure and functional mechanism of a human antimicrobial membrane channel

(2013) C. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Over-expression in Escherichia coli, purification and reconstitution in liposomes of the third member of the OCTN sub-family: The mouse carnitine transporter OCTN3

(2012) Mariafrancesca Scalise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Three-Dimensional Structures of Membrane Proteins from Genomic Sequencing

(2012) Thomas A. Hopf et al.   CELL

Investigational ABC transporter inhibitors

(2012) Marco Falasca et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

(2012) Ferdinando Palmieri   MOLECULAR ASPECTS OF MEDICINE

The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1

(2012) Susanna Bodoy et al.   MOLECULAR ASPECTS OF MEDICINE

Strategies of Bacterial Over Expression of Membrane Transporters Relevant in Human Health: The Successful Case of the Three Members of OCTN Subfamily

(2012) Cesare Indiveri et al.   MOLECULAR BIOTECHNOLOGY

An Overview of Transporter Information in Package Inserts of Recently Approved New Molecular Entities

(2012) Sheetal Agarwal et al.   PHARMACEUTICAL RESEARCH

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity

(2012) Francesca Oppedisano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inhibition of the OCTN2 carnitine transporter by HgCl2and methylmercury in the proteoliposome experimental model: insights in the mechanism of toxicity

(2012) Lorena Pochini et al.   TOXICOLOGY MECHANISMS AND METHODS

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps

(2012) Alice Verchère et al.   Scientific Reports

Drug Transporters in Drug Efficacy and Toxicity

(2011) M.K. DeGorter et al.   Annual Review of Pharmacology and Toxicology

Role of transporters in drug interactions

(2011) Hyo-Kyung Han   ARCHIVES OF PHARMACAL RESEARCH

Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed inEscherichia coli

(2011) Lorena Pochini et al.   BIOCHEMICAL JOURNAL

The role of amino acid transporters in inherited and acquired diseases

(2011) Stefan Bröer et al.   BIOCHEMICAL JOURNAL

The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: Kinetics and inactivation by methylmercury

(2011) Francesca Oppedisano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease

(2011) Lorena Pochini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effects of heavy metal cations on the mitochondrial ornithine/citrulline transporter reconstituted in liposomes

(2011) Annamaria Tonazzi et al.   BIOMETALS

Interaction of innovative small molecule drugs used for cancer therapy with drug transporters

(2011) K Mandery et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium

(2011) Matthew R. Whorton et al.   CELL

The P-glycoprotein multidrug transporter

(2011) Frances J. Sharom   Essays in Biochemistry

Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter

(2011) Toshinori Komatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Solute Carrier Transporters as Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy

(2011) Takeo Nakanishi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The mitochondrial carnitine/acylcarnitine carrier: Function, structure and physiopathology

(2011) Cesare Indiveri et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Aquaporins as gas channels

(2011) Marcela Herrera et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Biology of Human Sodium Glucose Transporters

(2011) Ernest M. Wright et al.   PHYSIOLOGICAL REVIEWS

Inactivation by Hg 2+ and methylmercury of the glutamine/amino acid transporter (ASCT2) reconstituted in liposomes: Prediction of the involvement of a CXXC motif by homology modelling

(2010) Francesca Oppedisano et al.   BIOCHEMICAL PHARMACOLOGY

The structural basis of secondary active transport mechanisms

(2010) Lucy R. Forrest et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glycosylation of the OCTN2 carnitine transporter: Study of natural mutations identified in patients with primary carnitine deficiency

(2010) Cristina Amat di San Filippo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Functional Reconstitution into Liposomes of Purified Human RhCG Ammonia Channel

(2010) Isabelle Mouro-Chanteloup et al.   PLoS One

Scientific and Regulatory Perspectives on Metabolizing Enzyme−Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions†

(2009) Lei Zhang et al.   MOLECULAR PHARMACEUTICS

Expression and function of the rat vesicular monoamine transporter 2

(2008) Yoav Adam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ins and Outs of Major Facilitator Superfamily Antiporters

(2008) Christopher J. Law et al.   Annual Review of Microbiology

Cell Free Expression and Functional Reconstitution of Eukaryotic Drug Transporters†

(2008) Thorsten Keller et al.   BIOCHEMISTRY

Diseases caused by defects of mitochondrial carriers: A review

(2008) Ferdinando Palmieri   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reconstitution into liposomes of the B°-like glutamine-neutral amino acid transporter from renal cell plasma membrane

(2008) Francesca Oppedisano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of β-lactam antibiotics with the mitochondrial carnitine/acylcarnitine transporter

(2008) Lorena Pochini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inactivation by omeprazole of the carnitine transporter (OCTN2) reconstituted in liposomes

(2008) Lorena Pochini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations

(2008) E SCHRODER et al.   CURRENT OPINION IN PHARMACOLOGY

Interaction of mildronate with the mitochondrial carnitine/acylcarnitine transport protein

(2008) Francesca Oppedisano et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process

(2008) Shiew-Mei Huang et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

(2008) M. Okabe et al.   MOLECULAR CANCER THERAPEUTICS

The Transporter Classification Database: recent advances

(2008) M. H. Saier et al.   NUCLEIC ACIDS RESEARCH

Luminal Na+/H+ exchange in the proximal tubule

(2008) I. Alexandru Bobulescu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia

(2008) Stefan Bröer   PHYSIOLOGICAL REVIEWS

Synthesis and characterization of carnitine nitro-derivatives

(2007) Oriana Piermatti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A micro-batchwise technique method for rapid reconstitution of functionally active mitochondrial ADP/ATP carrier from Jerusalem artichoke (Helianthus tuberosus L.) tubers

(2007) A. Spagnoletta et al.