Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Published 2018 View Full Article

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Title
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells
Authors
Keywords
cancer, metformin, syrosingopine, lactate, MCT1, MCT4, synthetic lethality
Journal
Cell Reports
Volume 25, Issue 11, Pages 3047-3058.e4
Publisher
Elsevier BV
Online
2018-12-12
DOI
10.1016/j.celrep.2018.11.043

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