Direct protein-lipid interactions shape the conformational landscape of secondary transporters

Lipid bilayer composition modulates the unfolding free energy of a knotted α-helical membrane protein

(2018) M. R. Sanders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative stability of Major Facilitator Superfamily transport proteins

(2017) Nicola J. Harris et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Structure and allosteric inhibition of excitatory amino acid transporter 1

(2017) Juan C. Canul-Tec et al.   NATURE

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer

(2017) Suraj Adhikary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced conformational dynamics of theEscherichia coliNa+/H+antiporter NhaA revealed by hydrogen/deuterium exchange mass spectrometry

(2017) Martin Lorenz Eisinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

(2017) Michael Landreh et al.   Nature Communications

Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE

(2017) Meng Ke et al.   PLoS Computational Biology

Shared Molecular Mechanisms of Membrane Transporters

(2016) David Drew et al.   Annual Review of Biochemistry

Mammalian Glucose Transporter Activity Is Dependent upon Anionic and Conical Phospholipids

(2016) Richard C. Hresko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

SLC transporters: structure, function, and drug discovery

(2016) Claire Colas et al.   MedChemComm

Lipids modulate the conformational dynamics of a secondary multidrug transporter

(2016) Chloé Martens et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In vitro synthesis of a Major Facilitator Transporter for specific active transport across Droplet Interface Bilayers

(2016) Heather E. Findlay et al.   Scientific Reports

Spontaneous Inward Opening of the Dopamine Transporter Is Triggered by PIP2-Regulated Dynamics of the N-Terminus

(2015) George Khelashvili et al.   ACS Chemical Neuroscience

Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Nguyen Minh Duc et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Structure and mechanism of the mammalian fructose transporter GLUT5

(2015) Norimichi Nomura et al.   NATURE

SLC transporters as therapeutic targets: emerging opportunities

(2015) Lawrence Lin et al.   NATURE REVIEWS DRUG DISCOVERY

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A chemiosmotic mechanism of symport

(2015) H. Ronald Kaback   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of lipids in mechanosensation

(2015) Christos Pliotas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A systematic survey of lipids across mouse tissues

(2014) Mohit Jain et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Structure of sugar-bound LacY

(2014) Hemant Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional architecture of MFS D-glucose transporters

(2014) M. G. Madej et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE

(2014) Goragot Wisedchaisri et al.   Nature Communications

Structural evidence for functional lipid interactions in the betaine transporter BetP

(2013) Caroline Koshy et al.   EMBO JOURNAL

Proper Fatty Acid Composition Rather than an Ionizable Lipid Amine Is Required for Full Transport Function of Lactose Permease fromEscherichia coli

(2013) Heidi Vitrac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flexible Gates Generate Occluded Intermediates in the Transport Cycle of LacY

(2013) Lukas S. Stelzl et al.   JOURNAL OF MOLECULAR BIOLOGY

Protonation drives the conformational switch in the multidrug transporter LmrP

(2013) Matthieu Masureel et al.   Nature Chemical Biology

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT

(2013) S. Doki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

(2013) Daohua Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose transporters in cancer metabolism

(2012) Kehinde Adekola et al.   CURRENT OPINION IN ONCOLOGY

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Protein dynamics viewed by hydrogen exchange

(2012) John J. Skinner et al.   PROTEIN SCIENCE

Proton-Coupled Dynamics in Lactose Permease

(2012) Magnus Andersson et al.   STRUCTURE

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

The Alternating-Access Mechanism of MFS Transporters Arises from Inverted-Topology Repeats

(2011) Sebastian Radestock et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Analysis of Membrane Proteins in Phospholipid Bilayer Nanodiscs by Hydrogen Exchange Mass Spectrometry

(2010) Christine M. Hebling et al.   ANALYTICAL CHEMISTRY

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

The Utility of Hydrogen/Deuterium Exchange Mass Spectrometry in Biopharmaceutical Comparability Studies

(2010) Damian Houde et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS

(2009) John R. Engen   ANALYTICAL CHEMISTRY

SuperLooper--a prediction server for the modeling of loops in globular and membrane proteins

(2009) P. W. Hildebrand et al.   NUCLEIC ACIDS RESEARCH

Interactions between Phosphatidylethanolamine Headgroup and LmrP, a Multidrug Transporter

(2008) Pierre Hakizimana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Salt-bridge Dynamics Control Substrate-induced Conformational Change in the Membrane Transporter GlpT

(2008) Christopher J. Law et al.   JOURNAL OF MOLECULAR BIOLOGY