Understanding the diversity of membrane lipid composition

Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids

(2017) Daisuke Hishikawa et al.   FEBS LETTERS

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

(2017) Johan-Owen De Craene et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells

(2017) Hideo Shindou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid sensing by mTOR complexes viade novosynthesis of phosphatidic acid

(2017) Deepak Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis

(2017) Yoshiko Iizuka-Hishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PNPLA1 Deficiency in Mice and Humans Leads to a Defect in the Synthesis of Omega-O-Acylceramides

(2017) Susanne Grond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Directing eicosanoid esterification into phospholipids

(2017) Valerie B. O’Donnell et al.   JOURNAL OF LIPID RESEARCH

Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy

(2017) Nozomu Kono et al.   MOLECULAR BIOLOGY OF THE CELL

The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic

(2017) Leslie N. Bone et al.   MOLECULAR BIOLOGY OF THE CELL

Protein–phospholipid interplay revealed with crystals of a calcium pump

(2017) Yoshiyuki Norimatsu et al.   NATURE

The role of interfacial lipids in stabilizing membrane protein oligomers

(2017) Kallol Gupta et al.   NATURE

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

(2017) J. Thomas Hannich et al.   Chemical Science

Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis

(2017) Takashi Hirama et al.   Nature Communications

PNPLA1 is a transacylase essential for the generation of the skin barrier lipid ω-O-acylceramide

(2017) Yusuke Ohno et al.   Nature Communications

PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis

(2017) Tetsuya Hirabayashi et al.   Nature Communications

Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling

(2017) Rebeca Caires et al.   Cell Reports

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

(2017) Matthew B Stone et al.   eLife

Phosphatidylethanolamine dynamics are required for osteoclast fusion

(2017) Atsushi Irie et al.   Scientific Reports

Mutations in MBOAT7 , Encoding Lysophosphatidylinositol Acyltransferase I, Lead to Intellectual Disability Accompanied by Epilepsy and Autistic Features

(2016) Anide Johansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations

(2016) George Hedger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Running up that hill: How to create cellular lipid gradients by lipid counter-flows

(2016) Joachim Moser von Filseck et al.   BIOCHIMIE

Lipid unsaturation and organelle dynamics

(2016) Hélène Barelli et al.   CURRENT OPINION IN CELL BIOLOGY

Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids

(2016) Sosuke Akagi et al.   FASEB JOURNAL

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

(2016) Assem Zhakupova et al.   FASEB JOURNAL

Features of the Phosphatidylinositol Cycle and its Role in Signal Transduction

(2016) Richard M. Epand   JOURNAL OF MEMBRANE BIOLOGY

Homeoviscous Adaptation and the Regulation of Membrane Lipids

(2016) Robert Ernst et al.   JOURNAL OF MOLECULAR BIOLOGY

A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism

(2016) Georgios Savoglidis et al.   METABOLIC ENGINEERING

A Eukaryotic Sensor for Membrane Lipid Saturation

(2016) Roberto Covino et al.   MOLECULAR CELL

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles

(2016) Rona Aviram et al.   MOLECULAR CELL

Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines

(2016) Nancy E. Braverman et al.   MOLECULAR GENETICS AND METABOLISM

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Photoswitchable diacylglycerols enable optical control of protein kinase C

(2016) James Allen Frank et al.   Nature Chemical Biology

The enigma of ceramide synthase regulation in mammalian cells

(2016) Marthe-Susanna Wegner et al.   PROGRESS IN LIPID RESEARCH

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

(2016) Akio Kihara   PROGRESS IN LIPID RESEARCH

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

(2016) Antonella Chiapparino et al.   PROGRESS IN LIPID RESEARCH

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Shaping the Endoplasmic Reticulum into a Social Network

(2016) Hong Zhang et al.   TRENDS IN CELL BIOLOGY

Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

(2016) Alessandro Pagliuso et al.   Nature Communications

A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition

(2016) Maud Magdeleine et al.   eLife

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions

(2015) Per Haberkant et al.   ACS Chemical Biology

A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses

(2015) Marielle S. Köberlin et al.   CELL

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells

(2015) Micah J. Niphakis et al.   CELL

Transbilayer Lipid Interactions Mediate Nanoclustering of Lipid-Anchored Proteins

(2015) Riya Raghupathy et al.   CELL

Cardiolipin metabolism and its causal role in the etiology of the inherited cardiomyopathy Barth syndrome

(2015) Gerard J. Gaspard et al.   CHEMISTRY AND PHYSICS OF LIPIDS

1-Deoxysphingolipids Encountered Exogenously and Madede Novo: Dangerous Mysteries inside an Enigma

(2015) Jingjing Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol

(2015) M. Maekawa et al.   JOURNAL OF CELL SCIENCE

ORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesis

(2015) Deanna Siow et al.   JOURNAL OF LIPID RESEARCH

Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

(2015) Mee-Sup Yoon et al.   MOLECULAR CELL

The systematic analysis of protein–lipid interactions comes of age

(2015) Antoine-Emmanuel Saliba et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

From zero to six double bonds: phospholipid unsaturation and organelle function

(2015) Bruno Antonny et al.   TRENDS IN CELL BIOLOGY

Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains

(2015) Dragomir Milovanovic et al.   Nature Communications

Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2

(2015) Huiseon Yang et al.   Nature Communications

Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains

(2015) Ivana Vonkova et al.   Cell Reports

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Mining the genome for lipid genes

(2014) Jan Albert Kuivenhoven et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

(2014) Takayuki Sassa et al.   Biomolecules & Therapeutics

BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission

(2014) Oliver Daumke et al.   CELL

Dividing Cells Regulate Their Lipid Composition and Localization

(2014) G. Ekin Atilla-Gokcumen et al.   CELL

Lysophospholipid Acyltransferases Mediate Phosphatidylcholine Diversification to Achieve the Physical Properties Required In Vivo

(2014) Takeshi Harayama et al.   Cell Metabolism

Regulation of Gene Expression through a Transcriptional Repressor that Senses Acyl-Chain Length in Membrane Phospholipids

(2014) Harald F. Hofbauer et al.   DEVELOPMENTAL CELL

Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controlsde NovoCeramide Synthesis in Mammalian Cells

(2014) Kerstin Kiefer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmalogens and fatty alcohols in rhizomelic chondrodysplasia punctata and Sjögren-Larsson syndrome

(2014) Ana R. Malheiro et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

(2014) Daisuke Hishikawa et al.   JOURNAL OF LIPID RESEARCH

Systematic lipidomic analysis of yeast protein kinase and phosphatase mutants reveals novel insights into regulation of lipid homeostasis

(2014) Aline Xavier da Silveira dos Santos et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

(2014) M. Pinot et al.   SCIENCE

Phospholipids that Contain Polyunsaturated Fatty Acids Enhance Neuronal Cell Mechanics and Touch Sensation

(2014) Valeria Vásquez et al.   Cell Reports

The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns

(2013) André Nadler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Vivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids

(2013) Per Haberkant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

(2013) Jean E. Vance   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identification of genes and pathways involved in the synthesis of Mead acid (20:3n−9), an indicator of essential fatty acid deficiency

(2013) Ikuyo Ichi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The complexity of sphingolipid biosynthesis in the endoplasmic reticulum

(2013) Rotem Tidhar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria-type GPAT is required for mitochondrial fusion

(2013) Yohsuke Ohba et al.   EMBO JOURNAL

Gain-of-function mutations in the phosphatidylserine synthase 1 (PTDSS1) gene cause Lenz-Majewski syndrome

(2013) Sérgio B Sousa et al.   NATURE GENETICS

Acid sphingomyelinase–ceramide system mediates effects of antidepressant drugs

(2013) Erich Gulbins et al.   NATURE MEDICINE

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

The biophysics and cell biology of lipid droplets

(2013) Abdou Rachid Thiam et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms

(2013) Atsushi Yamashita et al.   PROGRESS IN LIPID RESEARCH

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Lipid Sorting and Multivesicular Endosome Biogenesis

(2013) C. Bissig et al.   Cold Spring Harbor Perspectives in Biology

The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids

(2013) Jun Ding et al.   Cell Reports

Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis

(2012) Shoken Lee et al.   GENES TO CELLS

Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae

(2012) Susan A. Henry et al.   GENETICS

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes

(2012) Joo-Won Park et al.   HEPATOLOGY

Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis

(2012) Deanna L. Siow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disorders of phospholipids, sphingolipids and fatty acids biosynthesis: toward a new category of inherited metabolic diseases

(2012) F. Lamari et al.   JOURNAL OF INHERITED METABOLIC DISEASE

LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice

(2012) Hyeon-Cheol Lee et al.   MOLECULAR BIOLOGY OF THE CELL

The Sjögren-Larsson Syndrome Gene Encodes a Hexadecenal Dehydrogenase of the Sphingosine 1-Phosphate Degradation Pathway

(2012) Kanae Nakahara et al.   MOLECULAR CELL

Molecular recognition of a single sphingolipid species by a protein’s transmembrane domain

(2012) F.-Xabier Contreras et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Rab10 GTPase regulates ER dynamics and morphology

(2012) Amber R. English et al.   NATURE CELL BIOLOGY

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

(2012) Doris Berchtold et al.   NATURE CELL BIOLOGY

PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans

(2012) Anaïs Grall et al.   NATURE GENETICS

Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

(2012) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Membrane Curvature Sensing

(2011) Bruno Antonny   Annual Review of Biochemistry

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

(2011) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

LYCAT, a homologue ofC. elegans acl-8,acl-9, andacl-10, determines the fatty acid composition of phosphatidylinositol in mice

(2011) Rieko Imae et al.   JOURNAL OF LIPID RESEARCH

Study of Arachidonoyl Specificity in Two Enzymes of the PI Cycle

(2011) Yulia V. Shulga et al.   JOURNAL OF MOLECULAR BIOLOGY

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

(2011) Jae Man Lee et al.   NATURE

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chain length-specific properties of ceramides

(2011) Sabine Grösch et al.   PROGRESS IN LIPID RESEARCH

Biological membranes: the importance of molecular detail

(2011) Anthony G. Lee   TRENDS IN BIOCHEMICAL SCIENCES

Specificity of Intramembrane Protein-Lipid Interactions

(2011) F.-X. Contreras et al.   Cold Spring Harbor Perspectives in Biology

Distribution and Functions of Sterols and Sphingolipids

(2011) J. T. Hannich et al.   Cold Spring Harbor Perspectives in Biology

Revisiting Hydrophobic Mismatch with Free Energy Simulation Studies of Transmembrane Helix Tilt and Rotation

(2010) Taehoon Kim et al.   BIOPHYSICAL JOURNAL

A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

(2010) Hayley J. Sharpe et al.   CELL

A Disease-causing Mutation in the Active Site of Serine Palmitoyltransferase Causes Catalytic Promiscuity

(2010) Kenneth Gable et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice

(2010) James P. Bridges et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

(2010) Thomas D. Mullen et al.   JOURNAL OF LIPID RESEARCH

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Phosphatidic Acid Is a pH Biosensor That Links Membrane Biogenesis to Metabolism

(2010) B. P. Young et al.   SCIENCE

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

(2009) Manu V. Chakravarthy et al.   CELL

Dietary Docosahexaenoic Acid Supplementation Modulates Hippocampal Development in thePemt−/−Mouse

(2009) Kerry-Ann da Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Interactions between Sphingolipids and Sterols in Biological Membranes Regulating Cell Physiology

(2009) Xue Li Guan et al.   MOLECULAR BIOLOGY OF THE CELL

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

(2009) Hervé Guillou et al.   PROGRESS IN LIPID RESEARCH

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

AmiGO: online access to ontology and annotation data

(2008) Seth Carbon et al.   BIOINFORMATICS

Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels

(2008) Julien Chevallier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY