Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter

Synthesis, Biological, and Antitumor Activity of a Highly Potent 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitor with Proton-Coupled Folate Transporter and Folate Receptor Selectivity over the Reduced Folate Carrier That Inhibits β-Glycinamide Ribonucleotide Formyltransferase

(2011) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prevalence of a Loss-of-Function Mutation in the Proton-Coupled Folate Transporter Gene (PCFT-SLC46A1) Causing Hereditary Folate Malabsorption in Puerto Rico

(2011) Kris M. Mahadeo et al.   JOURNAL OF PEDIATRICS

Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption

(2011) Daniel Sanghoon Shin et al.   MOLECULAR GENETICS AND METABOLISM

Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

(2011) S. Kugel Desmoulin et al.   MOLECULAR PHARMACOLOGY

Properties of the Arg376 residue of the proton-coupled folate transporter (PCFT-SLC46A1) and a glutamine mutant causing hereditary folate malabsorption

(2010) Kris Mahadeo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Membrane Topological Analysis of the Proton-Coupled Folate Transporter (PCFT-SLC46A1) by the Substituted Cysteine Accessibility Method

(2010) Rongbao Zhao et al.   BIOCHEMISTRY

Mutational Analysis of Threonine 402 Adjacent to the GXXXG Dimerization Motif in Transmembrane Segment 1 of ABCG2

(2010) Orsolya Polgar et al.   BIOCHEMISTRY

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

(2010) D. S. Shin et al.   BLOOD

Synthesis and Antitumor Activity of a Novel Series of 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolate Inhibitors of Purine Biosynthesis with Selectivity for High Affinity Folate Receptors and the Proton-Coupled Folate Transporter over the Reduced Folate Carrier for Cellular Entry

(2010) Lei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors

(2010) S. K. Desmoulin et al.   MOLECULAR PHARMACOLOGY

MUTATION OF THE PROTON-COUPLED FOLATE TRANSPORTER GENE (PCFT-SLC46A1) IN TURKISH SIBLINGS WITH HEREDITARY FOLATE MALABSORPTION

(2010) Berna Atabay et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1

(2009) Ersin Selcuk Unal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hereditary folate malabsorption: A positively charged amino acid at position 113 of the proton-coupled folate transporter (PCFT/SLC46A1) is required for folic acid binding

(2009) Inbal Lasry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reversible severe combined immunodeficiency phenotype secondary to a mutation of the proton-coupled folate transporter

(2009) Arturo Borzutzky et al.   CLINICAL IMMUNOLOGY

Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues

(2009) Rongbao Zhao et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier

(2009) Zhanjun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Functional Roles of the His247and His281Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1

(2009) Ersin Selcuk Unal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study

(2009) Tudor Ciuleanu et al.   LANCET

A novel PCFT gene mutation (p.Cys66LeufsX99) causing hereditary folate malabsorption

(2009) Esther Meyer et al.   MOLECULAR GENETICS AND METABOLISM

N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT)

(2008) Ersin Selcuk Unal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A novel loss-of-function mutation in the proton-coupled folate transporter from a patient with hereditary folate malabsorption reveals that Arg 113 is crucial for function

(2008) I. Lasry et al.   BLOOD

Oligomeric Structure of the Human Reduced Folate Carrier

(2008) Zhanjun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Clinical Course and Genetic Defect in the PCFT Gene in a 27-Year-Old Woman with Hereditary Folate Malabsorption

(2008) Sang Hee Min et al.   JOURNAL OF PEDIATRICS

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier

(2008) R. Zhao et al.   MOLECULAR PHARMACOLOGY

Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia

(2007) Veedamali S. Subramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY