Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer’s disease model of differentiated neuroblastoma cell line

(2020) Mehmet Enes Arslan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Chemical composition and acetylcholinesterase inhibitory potential, in silico, of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel essential oil

(2020) Deyzi Caroline da Silva Barbosa et al.   INDUSTRIAL CROPS AND PRODUCTS

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

(2020) Md. Habibur Rahman et al.   Frontiers in Pharmacology

Further sesquiterpenoids from the rhizomes of Homalomena occulta and their anti-inflammatory activity

(2019) Jun-Li Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentos a: Investigation of a Reactive Enetrione Intermediate

(2019) Xu-Jie Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin

(2019) Mohammed N. A. Khalil et al.   PLoS One

Alkaloids and sesquiterpenes from roots and leaves of Lycium europaeum L. (Solanaceae) with antioxidant and anti-acetylcholinesterase activities

(2019) Houaria Bendjedou et al.   NATURAL PRODUCT RESEARCH

Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides

(2019) Yang Liu et al.   FITOTERAPIA

Sesquiterpenes from stigma maydis ( Zea mays ) as a crop by-product and their potential neuroprotection and inhibitory activities of A β aggregation

(2018) Xiao-Li Qi et al.   INDUSTRIAL CROPS AND PRODUCTS

Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease

(2018) Yunlong Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

β-amyloid cytotoxicity is prevented by natural achillolide A

(2018) Anat Elmann et al.   Journal of Natural Medicines

Amberboin and lipidiol: X-ray crystalographic data, absolute configuration and inhibition of cholinesterase

(2018) Mahmoud Fahmi Elsebai et al.   Phytochemistry Letters

(‒)-Pteroside N and pterosinone, new BACE1 and cholinesterase inhibitors from Pteridium aquilinum

(2018) Yun-Hyeok Choi et al.   Phytochemistry Letters

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

(2018) Bushra Shal et al.   Frontiers in Pharmacology

New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus

(2018) Qing-Yan Zhou et al.   FITOTERAPIA

Huperzine-A response to cognitive impairment and task switching deficits in patients with Alzheimer's disease

(2018) Amara Gul et al.   Journal of the Chinese Medical Association

The present and future of pharmacotherapy of Alzheimer’s disease: A comprehensive review

(2017) Abhinav Anand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant, α-amylase, and acetylcholinesterase inhibitory activities of Hertia cheirifolia essential oils: Influence of plant organs and seasonal variation

(2017) Najoua Rahali et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Discontinuation, Efficacy, and Safety of Cholinesterase Inhibitors for Alzheimer’s Disease: a Meta-Analysis and Meta-Regression of 43 Randomized Clinical Trials Enrolling 16 106 Patients

(2017) Lídia Blanco-Silvente et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

(2017) Zühal Güvenalp et al.   Records of Natural Products

Synaptic pathology: A shared mechanism in neurological disease

(2016) Christopher M. Henstridge et al.   AGEING RESEARCH REVIEWS

Sesquiterpenes of agarwood from Gyrinops salicifolia

(2016) Hang Shao et al.   FITOTERAPIA

Sesquiterpenes and a monoterpenoid with acetylcholinesterase (AchE) inhibitory activity from Valeriana officinalis var. latiofolia in vitro and in vivo

(2016) Heng-Wen Chen et al.   FITOTERAPIA

Chemical composition, aroma evaluation, and inhibitory activity towards acetylcholinesterase of essential oils from Gynura bicolor DC.

(2016) Mitsuo Miyazawa et al.   Journal of Natural Medicines

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Sesquiterpenoids from Chinese Agarwood Induced by Artificial Holing

(2016) Wei Li et al.   MOLECULES

Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities

(2016) Weng-Keong Chan et al.   MOLECULES

Therapeutic strategies for Alzheimer's disease in clinical trials

(2016) Justyna Godyń et al.   Pharmacological Reports

Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum

(2016) Amanda Leitolis et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth

(2016) Jing Xu et al.   Journal of Functional Foods

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

(2016) Yanfang Li et al.   Frontiers in Aging Neuroscience

Sesquiterpene lactones from Hedyosmum brasiliense induce in vitro relaxation of rat aorta and corpus cavernosum

(2016) Amanda Leitolis et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Anti-inflammatory and acetylcholinesterase activity of extract, fractions and five compounds isolated from the leaves and twigs of Artemisia annua growing in Cameroon

(2016) Rosine D. K. Chougouo et al.   SpringerPlus

Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease

(2015) Yong Li et al.   Chemical Biology & Drug Design

Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4β,10α-diol on memory impairment in a mouse model of Alzheimer

(2015) Solomon K.S. Amoah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

(2015) Mythily Srinivasan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Five new eudesmane-type sesquiterpenoids from Chinese agarwood induced by artificial holing

(2015) Wei Li et al.   FITOTERAPIA

Iridoids and sesquiterpenoids from the roots of Valeriana jatamansi Jones

(2015) Fa-Wu Dong et al.   FITOTERAPIA

Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenus disticha and Euonymus japonicus

(2015) Julio Alarcón et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Antioxidant, cholinesterase inhibition activities and essential oil analysis ofNelumbo nuciferaseeds

(2015) Shahnaz Khan et al.   NATURAL PRODUCT RESEARCH

Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza

(2015) Chunmei Zhang et al.   Phytochemistry Letters

Two new sesquiterpene coumarins from the seeds of Ferula sinkiangensis

(2015) Guangzhi Li et al.   Phytochemistry Letters

Sesquiterpene Lactones from Cynara cornigera: Acetyl Cholinesterase Inhibition and In Silico Ligand Docking

(2015) Mohamed-Elamir Hegazy et al.   PLANTA MEDICA

Sesquiterpene Lactones fromArtemisiaGenus: Biological Activities and Methods of Analysis

(2015) Bianca Ivanescu et al.   Journal of Analytical Methods in Chemistry

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease?

(2015) Niloo Karunaweera et al.   Frontiers in Molecular Neuroscience

Inhibition of Acetylcholinesterase Activity by Dihydro-β-agarofuran Sesquiterpenes Isolated from Chilean Celastraceae

(2015) Julio Alarcón et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Natural sesquiterpen lactones as acetylcholinesterase inhibitors

(2014) HOMA HAJIMEHDIPOOR et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Pharmacological Activity of Sesquiterpene Lactones

(2014) J. Matejić et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Sesquiterpenoids fromChloranthus henryiand Their Anti-neuroinflammatory Activities

(2014) Li-Jun Wang et al.   CHEMISTRY & BIODIVERSITY

Natural Products as Sources of New Lead Compounds for the Treatment of Alzheimer’s Disease

(2014) Ling Huang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model.

(2014) M Bond et al.   HEALTH TECHNOLOGY ASSESSMENT

Screening of β-secretase and acetylcholinesterase inhibitors from plant resources

(2014) Kazuya Murata et al.   Journal of Natural Medicines

Marsupellins A–F, ent-Longipinane-Type Sesquiterpenoids from the Chinese Liverwort Marsupella alpine with Acetylcholinesterase Inhibitory Activity

(2014) Jiaozhen Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Models of β-amyloid induced Tau-pathology: the long and “folded” road to understand the mechanism

(2014) Ilie-Cosmin Stancu et al.   Molecular Neurodegeneration

Two New Guaiane Sesquiterpenoids from Daphne holosericea (Diels) Hamaya

(2014) Qing-Yun Ma et al.   MOLECULES

The Effects of Sesquiterpenes-Rich Extract ofAlpinia oxyphyllaMiq. on Amyloid-β-Induced Cognitive Impairment and Neuronal Abnormalities in the Cortex and Hippocampus of Mice

(2014) Shao-Huai Shi et al.   Oxidative Medicine and Cellular Longevity

Fragrant agarofuran and eremophilane sesquiterpenes in agarwood ‘Qi-Nan’ from Aquilaria sinensis

(2014) De-Lan Yang et al.   Phytochemistry Letters

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa

(2013) Muhammad Ibrahim et al.   Chemistry Central Journal

Sesquiterpenoids Lactones: Benefits to Plants and People

(2013) Martin Chadwick et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aβ40 modulates GABAAreceptor α6 subunit expression and rat cerebellar granule neuron maturation through the ERK/mTOR pathway

(2013) Xiao-Qin Zhan et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer’s disease: amino acid levels and brain metabolic status

(2013) Maria Concetta Gueli et al.   NEUROLOGICAL SCIENCES

Butyrylcholinesterase and the cholinergic system

(2013) G.A. Reid et al.   NEUROSCIENCE

Costunolide: A novel anti-cancer sesquiterpene lactone

(2012) Azhar Rasul et al.   Bangladesh Journal of Pharmacology

Ethnobotanical Treatment Strategies Against Alzheimers Disease

(2012) Melanie-Jayne R. Howes et al.   Current Alzheimer Research

Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells

(2012) Qiuhong Wang et al.   MOLECULES

Anti-acetylcholinesterase and Antioxidant Activity of Essential Oils from Hedychium gardnerianum Sheppard ex Ker-Gawl

(2012) Miguel Arruda et al.   MOLECULES

A new sesquiterpene lactone fromSarcandra glabra

(2012) Xiao-Ru Hu et al.   NATURAL PRODUCT RESEARCH

Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

(2012) Musthafa M. Essa et al.   NEUROCHEMICAL RESEARCH

Anti-Inflammatory Sesquiterpene Lactones fromLychnophora trichocarphaSpreng. (Brazilian Arnica)

(2012) Fernanda C. Ferrari et al.   PHYTOTHERAPY RESEARCH

Ayurvedic medicinal plants for Alzheimer's disease: a review

(2012) Rammohan V Rao et al.   Alzheimers Research & Therapy

The role of β-amyloid peptide in neurodegenerative diseases

(2011) A.V. Maltsev et al.   AGEING RESEARCH REVIEWS

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

(2011) Cesare Mancuso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dihydro-β-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents

(2011) David Torres-Romero et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sesquiterpenoids and Lignans from the Roots of Valeriana officinalis L.

(2011) Peng-Cheng Wang et al.   CHEMISTRY & BIODIVERSITY

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

The Role of Phytochemicals in the Treatment and Prevention of Dementia

(2011) Melanie-Jayne R. Howes et al.   DRUGS & AGING

Current perspectives on pharmacotherapy of Alzheimer's disease

(2011) Kanwaljit Chopra et al.   EXPERT OPINION ON PHARMACOTHERAPY

Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity

(2011) Paola E. Ordóñez et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural Sesquiterpenoids as Cytotoxic Anticancer Agents

(2011) Q.-F. Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A new sesquiterpenoid from the rhizomes ofHomalomena sagittifolia

(2011) K.C. Wong et al.   NATURAL PRODUCT RESEARCH

Sesquiterpene coumarins

(2011) Anna Gliszczyńska et al.   PHYTOCHEMISTRY REVIEWS

Acetylcholinesterase: From 3D structure to function

(2010) Hay Dvir et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities

(2010) Gülsen Tel et al.   FOOD AND CHEMICAL TOXICOLOGY

Acetylcholinesterase Inhibitory Activity of Volatile Oil from Peltophorum dasyrachis Kurz ex Bakar (Yellow Batai) and Bisabolane-Type Sesquiterpenoids

(2010) Mai Fujiwara et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Butyrylcholinesterase for protection from organophosphorus poisons: Catalytic complexities and hysteretic behavior

(2009) Patrick Masson et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease

(2009) Binggui Sun et al.   Cell Stem Cell

Alterations in Cortical Excitation and Inhibition in Genetic Mouse Models of Huntington's Disease

(2009) D. M. Cummings et al.   JOURNAL OF NEUROSCIENCE

Sesquiterpene coumarins from the fruits ofFerula badrakema

(2009) M. Iranshahi et al.   PHARMACEUTICAL BIOLOGY

Chemical Constituents and Bioactivities of Plants of Chloranthaceae

(2008) Cong-Mei Cao et al.   CHEMISTRY & BIODIVERSITY

Natural sesquiterpenoids

(2008) Braulio M. Fraga   NATURAL PRODUCT REPORTS

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

(2008) Colin Kehrer   Frontiers in Molecular Neuroscience

In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: Thin layer chromatography versus microplate methods

(2007) Saviana Di Giovanni et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES