Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 63, Issue 47, Pages 10250-10256Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.5b04168
Keywords
Celastraceae; Eudesmanolides; Maytenus disticha; Euonimus japonicus; dihydroagarofurans; acetylcholinesterase
Funding
- Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (CONICYT), through FONDECYT Program [1130463]
Ask authors/readers for more resources
Natural cholinesterase inhibitors have been found in many biological sources. Nine compounds with agarofuran (epoxyeudesmane) skeletons were isolated from seeds and aerial parts of Maytenus disticha and Euonymus japonicus. The identification and structural elucidation of compounds were based on spectroscopic data analyses. All compounds had inhibitory acetylcholinesterase (AChE) activity. These natural compounds, which possessed mixed or uncompetitive mechanisms of inhibitory activity against AChE, may be considered as models for the design and development of new naturally occurring drugs for management strategies for neurodegenerative diseases. This is the first report of these chemical structures for seeds of M. disticha.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available