Article
Chemistry, Medicinal
Carolina Marcucci, Marina Rademacher, Fabiola Kamecki, Valentina Pastore, Hernan Geronimo Bach, Rafael Alejandro Ricco, Marcelo Luis Wagner, Damijan Knez, Stanislav Gobec, Natalia Colettis, Mariel Marder
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein accumulation, oxidative stress, and neurotransmitter alterations. A comparative study of valerian extracts from endemic Argentinian species showed that V. carnosa had the most promising results against AD-related biological targets.
Article
Nutrition & Dietetics
Andrzej Jaskiewicz, Grazyna Budryn, Miguel Carmena-Bargueno, Horacio Perez-Sanchez
Summary: The study found that sesquiterpene lactones in chicory extracts have a strong inhibitory effect on acetylcholinesterase, especially lactucopicrin. Different chicory extracts exhibit complementary patterns in binding the AChE active site.
Article
Plant Sciences
Majid Rasool Kamli, Abeer Abdullah M. Sharaf, Jamal S. M. Sabir, Irfan A. Rather
Summary: The ethyl-acetate extract showed the strongest inhibitory effect against AChE and had the highest antioxidant potential. It also contained the highest total phenolic content, suggesting it may serve as a potential pharmacological lead for treating cognitive disorders.
Article
Biochemistry & Molecular Biology
Dao-Qun Shi, Jia-Jin Liu, Yu-Mei Feng, Yan Zhou, Cai-Cen Liao, Dan Liu, Rong-Tao Li, Hong-Mei Li
Summary: In this study, twenty-six iridoids and ten sesquiterpenoids were isolated from the roots and rhizomes of Valeriana officinalis. One of the isolated iridoids, named iridoidvol A, is the first example of an iridoid with sesquiterpenoid acid ester. Additionally, isovaltrate isovaleroyloxyhydrin exhibited a significant inhibitory effect on NO production.
Article
Chemistry, Organic
Miaomiao Wang, Shuliang Wang, Yanan Li, Panfeng Wu, Ping Yi, Liejun Huang, Wei Gu, Chengyan Zhou, Xiaojiang Hao, Chunmao Yuan
Summary: In this study, a rare sesquiterpenoid-alkaloid hydrid and two biosynthetic related compounds were isolated from the roots of Valeriana officinalis var. latifolia Miq. These compounds exhibited selective inhibitory activities against BuChE and molecular docking analysis provided insights into their recognition mechanism.
TETRAHEDRON LETTERS
(2022)
Article
Plant Sciences
Katarzyna Barbara Baczek, Olga Kosakowska, Maja Boczkowska, Paulina Bolc, Rafal Chmielecki, Ewelina Pioro-Jabrucka, Kavana Raj, Zenon Weglarz
Summary: This study evaluated the intraspecific variability of common valerian in Poland, focusing on the developmental traits, chemical composition, and genetic parameters of wild-growing populations and a specific landrace. The results showed high developmental and chemical variabilities among the wild-growing populations, with no clear relation to their origin region. The wild-growing populations had higher levels of essential oils and lower seed germinability compared to the landrace.
Article
Biochemistry & Molecular Biology
Prabhat Tiwari, Nicholas S. Tolwinski
Summary: A dementia case is diagnosed every three seconds worldwide, with 50-60% of cases being caused by Alzheimer's disease (AD). The deposition of amyloid beta (Aβ) is believed to be correlated with the onset of dementia, although it remains unclear whether Aβ is causative. Optogenetic techniques provide a precise way to regulate cellular dynamics and could offer a better understanding of the etiology of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agricultural Engineering
Mahsa Khatooni, Hassan Karimmojeni, Ali Gholami Zali, Jamshid Razmjoo, Te-Ming Tseng
Summary: This study investigated the effects of salicylic acid (SA) and bentazon on valerian. The results showed that exogenous application of SA positively impacted bentazon-exposed plants, reducing phytotoxicity damage and enhancing antioxidant enzyme system.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Soo Hyun Cho, Sookyoung Woo, Changsoo Kim, Hee Jin Kim, Hyemin Jang, Byeong C. Kim, Si Eun Kim, Seung Joo Kim, Jun Pyo Kim, Young Hee Jung, Samuel Lockhart, Rik Ossenkoppele, Susan Landau, Duk L. Na, Michael Weiner, Seonwoo Kim, Sang Won Seo
Summary: This study aimed to construct a disease course model from preclinical AD to AD dementia, finding that ADAS-cog 13 scores decreased most rapidly in women APOE epsilon 4 carriers and most slowly in men APOE epsilon 4 non-carriers. The results suggest that both sex and APOE epsilon 4 status have an impact on the progression of AD.
SCIENTIFIC REPORTS
(2021)
Article
Plant Sciences
Seyyedeh Atefeh Mousavi, Neda Dalir, Rasoul Rahnemaie, Rainer Schulin
Summary: This study found that exogenous methionine could reduce Cd accumulation in valerian roots, while increasing Cd uptake in the shoots. The addition of phosphate affected root Cd contents due to increased apoplastic Cd binding. However, in the presence of methionine, the phosphate effect on root Cd accumulation was mainly due to increased symplastic mot Cd allocation.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Yang Liu, Simon Schallhart, Toni Tykka, Matti Rasanen, Lutz Merbold, Heidi Hellen, Petri Pellikka
Summary: The study examined the mixing ratios of BVOCs in various ecosystems in southern Kenya, revealing different proportions of isoprene and monoterpenoids in the total mixing ratios across forests, agricultural areas, bushlands, and grasslands. Monoterpenoids, especially in certain landscapes, were found to have a significant impact on the total BVOC mixing ratios.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Shi-Wei Li, Bian-Xia Xue, Tian-Tian Yang, Ran Li, Mingjie Zhang, Miao Wang, Li-Hua Zhang, Peng Zhang, Yi Zhang, Tao Wang, Shao-Xia Wang, Hong-Hua Wu
Summary: Nine previously undescribed compounds were isolated from Valerian officinalis L. The structures of these compounds were determined by spectroscopic analysis, and their absolute configurations were established by experiments and simulations. Three of these compounds showed potential anti-neuroinflammatory activity.
Review
Cell Biology
Lucia Scipioni, Francesca Ciaramellano, Veronica Carnicelli, Alessandro Leuti, Anna Rita Lizzi, Noemi De Dominicis, Sergio Oddi, Mauro Maccarrone
Summary: This article reviews the role of microglial cells in chronic inflammation in Alzheimer's disease (AD) and the involvement of endocannabinoids in regulating their activity.
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Victor M. Barbera, Jordi Alom, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: In Alzheimer's disease, the inactive and active forms of acetylcholinesterase (AChE) exhibit differences in their glycosylation pattern, particularly in the presence of terminal mannoses in the active forms. Sporadic AD patients have reduced binding to terminal mannoses compared to non-demented individuals, while familial AD patients with PSEN1 gene mutations have higher binding. Furthermore, presenilin-1 (PS1) modulates AChE trafficking and maturation in Golgi regions, promoting the presence of active forms in the cell membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Qiong Jin, Yun-Li Zhao, Ya-Ping Liu, Ruo-Song Zhang, Pei-Feng Zhu, Lan-Qin Zhao, Xu-Jie Qin, Xiao-Dong Luo
Summary: This study supported the traditional use of K. officinalis by evaluating the anti-inflammatory and analgesic effects of its purified MIAs. The results showed that the purified MIAs displayed significant anti-inflammatory effects in vitro and in vivo, providing potential bioactive compounds for further chemical modification and pharmacological investigation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Substance Abuse
Chen Mo, Jingtao Wang, Zhenyao Ye, Hongjie Ke, Song Liu, Kathryn Hatch, Si Gao, Jessica Magidson, Chixiang Chen, Braxton D. D. Mitchell, Peter Kochunov, L. Elliot Hong, Tianzhou Ma, Shuo Chen
Summary: The study found a significant causal effect of smoking on the brain age gap, suggesting that smoking prevention can be an effective intervention for accelerated brain aging and age-related decline in cognitive function.
Article
Engineering, Chemical
Jintao Wang, Hao Jing, Yaning Feng, Haiwen Ge, Liang Chen, Jie Lin, Zhaojun Xi, Xinguang Cui
Summary: This study numerically investigates the behavior of Martian micro-particles in a human alveolar model under Martian gravity. It considers various physical and physiological factors and makes important findings: 1) Martian particle deposition is sensitive to alveolar direction and respiratory depth, but not to wall motion pattern; 2) particle size and density affect the starting time and duration of deposition; 3) compared to Earth gravity, deposition efficiency decreases and deposition time is prolonged under Martian gravity. It concludes that particle deposition under Martian gravity differs significantly from that under Earth gravity.
Article
Multidisciplinary Sciences
Bowen Bai, Qipeng Yang, Haowen Shu, Lin Chang, Fenghe Yang, Bitao Shen, Zihan Tao, Jing Wang, Shaofu Xu, Weiqiang Xie, Weiwen Zou, Weiwei Hu, John E. E. Bowers, Xingjun Wang
Summary: In this work, optical convolution is achieved through a time-wavelength plane stretching approach on a microcomb-driven chip-based photonic processing unit. Optical neural networks (ONN) have greatly benefited from parallel convolution-operation technology, which utilizes the dimension of optical wavelength to enhance complexity and functionality. However, challenges in high-level integration and on-chip operation remain for this advanced architecture. The authors develop a dedicated control and operation protocol, enabling a record high weight precision and demonstrating comparable processing capability to that of a digital computer in proof-of-concept experiments.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Jintao Wang, Jianqiang Wang, Fangcheng Duan, Hongtao Chen
Summary: With the challenge of high-temperature materials, a Cu@Cu6Sn5 core-shell bimetallic particles were successfully prepared as a new solder material for the packaging of high-power electronic devices, resulting in a Cu3Sn all-IMC solder joint consisting of equiaxed Cu3Sn grains and a small portion of columnar Cu3Sn grains. In columnar growth, Sn is the dominant diffusing species, while in equiaxed growth, Cu is the dominant diffusing species.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Zhenyu Wang, Jintao Wang, Ze Li, Ziqiang Chen, Lianchao Shangguan, Siyu Fan, Yu Duan
Summary: Flexible perovskite solar cells are promising new energy devices with high defect tolerance, strong solar absorption, and low non-radiative carrier recombination rates. However, their operational stability and moisture corrosion resistance need improvement. This study developed a highly cross-linked, dense flexible encapsulation material AlOC using Plasma-Enhanced Molecular Layer Deposition. The resulting encapsulation film exhibited excellent barrier performance and flexibility, making it suitable for flexible perovskite solar cell applications.
Article
Engineering, Environmental
Xinguang Cui, Wei Song, Yuan Xue, Hanxiong Guan, Jinhua Zhang, Xinxing He, Honglei Ma, Ming Lei, Jintao Wang, Yichao Li
Summary: Understanding how lunar dust particles deposit in the human respiratory system is crucial for protecting astronauts from lunar dust toxicity. A Euler-Lagrangian method is used to track the motion of lunar dust particles in a human oral airway model. The study considers different factors such as inspiration rates, particle sizes, abnormal pressures, and temperatures. The findings show that most lunar dust particles tend to enter the right lung, especially the upper right lobe. Lower ambient pressure leads to fewer particles depositing in the upper airway and more entering the lung. Lower temperature results in more particles depositing in the upper airway and fewer in the lung.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Hai-Yan Huang, Qian Wang, Chun-Yan Zhang, Zi-Xiang Chen, Jin-Tao Wang, Xiang-Wen Liao, Ru-Jian Yu, Yan-Shi Xiong
Summary: In this study, four ruthenium complexes modified with selenium-ether were synthesized and showed excellent antibacterial activity against Staphylococcus aureus (S. aureus). The most active complex, Ru(II)-4, efficiently targeted the bacterial cell membrane, preventing drug resistance and inhibiting biofilm formation. In toxicity experiments, Ru(II)-4 exhibited low mammalian toxicity. In vivo tests using both G. mellonella wax worms and mouse skin infection models confirmed the potential of Ru(II)-4 as an effective antibacterial agent against S. aureus infections, with minimal toxicity to mouse tissue. These findings highlight the promising strategy of introducing selenium-atom into ruthenium compounds for developing interesting antibacterial agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Ziwen Lv, Jintao Wang, Fengyi Wang, Weiwei Zhang, Jianqiang Wang, Chunjin Hang, Hongtao Chen
Summary: In this study, Cu6Sn5 nanoparticles were added to SAC305 solder paste to improve its mechanical strength and service reliability. The addition of Cu6Sn5 NPs enhanced the solderability and shear strength of the composite solder paste, leading to improved reliability in harsh operating environments.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Jianqiang Wang, Fangcheng Duan, Jintao Wang, Weiwei Zhang, Luobin Zhang, Mingyu Li, Chunjin Hang, Hongtao Chen, Jiahao Liu
Summary: In recent years, porous metals have been used for transient liquid phase bonding due to their high specific surface areas. However, the reliability issues of porous metal joints have been neglected in current studies. In this study, we prepared a porous Cu joint for high-temperature-resistant packaging and investigated its aging and thermal shock resistance. The results showed that the porous Cu joints exhibited good aging resistance and excellent thermal shock resistance.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Physical
Shuming Chen, Jintao Wang, Zhenyu Wang, Ziqiang Chen, Kai Fang, Chenyang He, Ning Jiang, Jian Zhang, Ye Li, Chuannan Li, Peng Li, Wenlong Jiang, Yu Duan
Summary: In this study, the additive 343FP was introduced into PTAA and it was found that the addition of 343FP improved charge transport properties and device efficiency of the resulting perovskite solar cell. Furthermore, the device with 343FP-doped PTAA exhibited better environmental stability.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Instruments & Instrumentation
Jintao Wang, Wang Jintao, Liu Xiang, Zhang Jingyue, Tong Lin, Guo Ligong, Bao Xuesong
Summary: This paper presents the design of an automatic wall-climbing robot for measuring the variation in the radius of different courses at different heights in large vertical storage tanks. The robot is equipped with permanent magnet adsorption, crawler movement, inclination angle sensor, and real-time software control, ensuring accurate volume measurement. The experimental results demonstrate the accuracy and efficiency of the robot system.
MAPAN-JOURNAL OF METROLOGY SOCIETY OF INDIA
(2023)
Article
Energy & Fuels
Chenyang He, Jintao Wang, Shuming Chen, Yibin Zhou, Ning Jiang, Jian Zhang, Yu Duan
Summary: The researchers designed a sandwich-type transparent conductive electrode by combining atomic layer deposition ZnO and thermally evaporated Ag films, proving that its film conductivity and optical transmittance are superior to metal electrodes with the same thickness. By using an optimized solution-based thin and continuous CH3NH3PbI3 (MAPbI(3)) film as the light absorber layer, the semitransparent perovskite solar cells (ST-PSCs) achieved a power conversion efficiency of 10% and an average visible transmittance of 19.6%. These findings illustrate a novel structure design strategy to overcome the contradiction between the efficiency and transparency of ST-PSCs.
Article
Engineering, Electrical & Electronic
Ziwen Lv, Jintao Wang, Fengyi Wang, Weiwei Zhang, Jianqiang Wang, Fuquan Li, Hongtao Chen
Summary: The increase in packaging and power density has resulted in a higher electric field strength between solder joints and increased potential for failure due to electrochemical migration. To enhance the anti-electrochemical migration ability of SAC305 solder, Cu6Sn5 nanoparticles (NPs) were added to the paste and their mechanism for inhibiting ECM was studied. Cu6Sn5 NPs were prepared through ultrasound-assisted chemical reduction and composite solder pastes were prepared by mechanically mixing them with SAC305. In situ observation showed that adding 0.6 wt% Cu6Sn5 NPs effectively inhibited ECM by prolonging the incubation period, but exceeding this amount led to accelerated failure. Furthermore, Cu6Sn5 NPs increased the threshold for instantaneous failure under high voltage.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Jintao Wang, Fangcheng Duan, Ziwen Lv, Si Chen, Xiaofeng Yang, Hongtao Chen, Jiahao Liu
Summary: This review focuses on the measurement methods used to evaluate the geometry and electrical properties of through-silicon vias (TSVs) and examines the reliability issues associated with TSVs in 3D integrated circuits (ICs). Non-destructive measurement techniques for TSV contours and copper fillings have been researched, including high-frequency signal analysis methods and thermal detection methods. The reliability risks of TSVs arise from various factors such as copper contamination, thermal fields in 3D-ICs, stress fields, noise coupling, and interactions between multiple physical fields. Designing reliable 3D-ICs with TSVs requires electrical characterization of copper contamination, assessment of stress distribution using micro-Raman spectroscopy and finite element simulations, and the proposal of shield insertion to mitigate cross-coupling effects.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Jintao Wang, Jianqiang Wang, Luobin Zhang, Ziwen Lv, Hongtao Chen, Mingyu Li
Summary: An intermetallic compound (IMC) capsule was developed to optimize the interfacial properties of copper pillars by adding Co and overcome the oxidation tendency of Co. The transformation process of CoSn2 nanoparticles into CoSn3 at the nanoscale was comprehensively analyzed using in situ heating transmission electron microscopy (TEM). The experimental results showed that CoSn2 nanoparticle growth occurred through polymerization, while CoSn3 nanoparticle formation relied on the reaction between CoSn2 and Sn.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
