Journal
CHEMISTRY & BIODIVERSITY
Volume 11, Issue 6, Pages 919-928Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201300283
Keywords
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Funding
- NSFC [81273401, 81202420]
- STCSM [11DZ1921203]
- Ph.D. Programs Foundation of Ministry of Education (MOE) of China [20120071110049, 20120071120049]
- MOST [2011ZX09307-002-01]
- National Basic Research Program of China (973 Program) [2013CB530700]
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Five new and seven known mono-sesquiterpenoids (1-5 and 6-12, resp.) together with five known lindenane-type disesquiterpenoids, 13-17, were isolated from the whole plant of Chloranthus henryi. Based on spectroscopic methods, the new structures were established to be (5S,6R,8S,10R)-6-hydroxyeudesma-4(15), 7(11)-diene-12,8-olide (1), 6 alpha-hydroxyeudesma-4(15), 7(11), 8(9)-triene-12,8-olide (2), 8,12-epoxy-1 beta-hydroxyeudesma-4(15), 7,11-trien-6-one (3), 12-oxochloraniolide A (4), and (4 alpha)-8-hydroxy-12-norcardina-6,8,10-trien-11-one (5), respectively. Among the isolates, compound 2, zederone epoxide (8), spicachlorantin G (13), chloramultilide A (14), shizukaol B (15), and spicachlorantin B (17) showed significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells with relatively low cytotoxicity.
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