β-amyloid cytotoxicity is prevented by natural achillolide A

Impact of a discordant helix on β-amyloid structure, aggregation ability and toxicity

(2017) Yi-Cheng Chen   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Glutamate Toxicity to Differentiated Neuroblastoma N2a Cells Is Prevented by the Sesquiterpene Lactone Achillolide A and the Flavonoid 3,5,4′-Trihydroxy-6,7,3′-Trimethoxyflavone from Achillea fragrantissima

(2017) Anat Elmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tanshinone IIA Inhibits Glutamate-Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH-SY5Y Human Neuroblastoma Cells

(2017) Haifeng Li et al.   Oxidative Medicine and Cellular Longevity

Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular mechanisms

(2016) Kun-Yuan Chiu et al.   CANCER LETTERS

Antibody-Based Drugs and Approaches Against Amyloid-β Species for Alzheimer’s Disease Immunotherapy

(2016) Jing Liu et al.   DRUGS & AGING

Achillolide A Protects Astrocytes against Oxidative Stress by Reducing Intracellular Reactive Oxygen Species and Interfering with Cell Signaling

(2016) Anat Elmann et al.   MOLECULES

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Flavonoids and Dementia: An Update

(2015) I.E. Orhan et al.   CURRENT MEDICINAL CHEMISTRY

Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4β,10α-diol on memory impairment in a mouse model of Alzheimer

(2015) Solomon K.S. Amoah et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Interplay of Akt and ERK in Aβ Toxicity and Insulin-Mediated Protection in Primary Hippocampal Cell Culture

(2015) Rasoul Ghasemi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The role of oxidative stress in anticancer activity of sesquiterpene lactones

(2015) Katarzyna Gach et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Downregulation of Microglial Activation by Achillolide A

(2015) Anat Elmann et al.   PLANTA MEDICA

Recent Updates in the Treatment of Neurodegenerative Disorders Using Natural Compounds

(2014) Mahmood Rasool et al.   Evidence-based Complementary and Alternative Medicine

Neuroprotection of Atractylenolide III from Atractylodis macrocephalae Against Glutamate-Induced Neuronal Apoptosis Via Inhibiting Caspase Signaling Pathway

(2014) Chao Liu et al.   NEUROCHEMICAL RESEARCH

3,5,4′-Trihydroxy-6,7,3′-trimethoxyflavone protects astrocytes against oxidative stress via interference with cell signaling and by reducing the levels of intracellular reactive oxygen species

(2014) Anat Elmann et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms of Action of Phytochemicals from Medicinal Herbs in the Treatment of Alzheimerʼs Disease

(2014) Mi Kim et al.   PLANTA MEDICA

Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease

(2013) Filipa I. Baptista et al.   ACS Chemical Neuroscience

Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability

(2013) Lipeng Dong et al.   MEDIATORS OF INFLAMMATION

Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis

(2012) Chi-Chang Huang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

(2012) Musthafa M. Essa et al.   NEUROCHEMICAL RESEARCH

Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice

(2011) Ross Zeitlin et al.   BRAIN RESEARCH

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer

(2011) Irmgard Merfort   CURRENT DRUG TARGETS

Parthenolide Blocks Cocaines Effect on Spontaneous Firing Activity of Dopaminergic Neurons in the Ventral Tegmental Area

(2011) David Schwarz et al.   Current Neuropharmacology

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

(2011) Robert J. Williams et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

(2011) Ju-Xian Song et al.   JOURNAL OF ETHNOPHARMACOLOGY

On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression

(2011) Elvis Cuevas et al.   NEUROTOXICOLOGY AND TERATOLOGY

Activation of JNK Signaling Mediates Amyloid-ß-Dependent Cell Death

(2011) Meghana Tare et al.   PLoS One

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease

(2010) Steven P. Braithwaite et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of a sesquiterpene lactone and flavanones from Paulownia tomentosa Steud. against glutamate-induced neurotoxicity in primary cultured rat cortical cells

(2010) Soo-Ki Kim et al.   PHYTOTHERAPY RESEARCH

Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35

(2009) Yury G. Kaminsky et al.   EXPERIMENTAL NEUROLOGY

Protective effects of dehydrocostus lactone against hydrogen peroxide-induced dysfunction and oxidative stress in osteoblastic MC3T3-E1 cells

(2009) Eun Mi Choi et al.   TOXICOLOGY IN VITRO