Article
Biochemistry & Molecular Biology
Thomas S. Webberley, Ryan J. Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R. Michael, Sophie Thomas, Meg Rees, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Duolao Wang, Timothy R. Hughes
Summary: This study assessed the neuroprotective potential of the Lab4P probiotic consortium in aging and metabolic syndrome-associated neurodegenerative pathologies. The results showed that supplementation with probiotics prevented cognitive decline, hippocampal neuron deterioration, and inflammation in mice. In human cell culture models, probiotic metabolites demonstrated a neuroprotective capability against beta-amyloid challenge. Overall, these findings suggest that Lab4P has the potential to be a neuroprotective agent and support further research in other neurodegenerative conditions in animal models and human studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Yijing Chen, Jinying Xu, Yu Chen
Summary: Emerging evidence suggests that gut microbiota plays a crucial role in regulating brain activity and cognitive functions through the microbiota-gut-brain axis. The mechanisms by which gut microbiota regulate neurotransmitter production, transportation, and functioning are not well understood, nor are the effects of these interactions on normal brain functions and cognition. Dysbiosis of the microbiome can adversely affect cognitive function, particularly in neurodegenerative diseases like Alzheimer's and Parkinson's.
Review
Biochemistry & Molecular Biology
Marta Perez-Gomez Moreta, Natalia Burgos-Alonso, Maria Torrecilla, Jose Marco-Contelles, Cristina Bruzos-Cidon
Summary: The study confirmed a low efficacy of AChEI in improving cognitive symptoms of patients with mild to moderate AD, especially in cognitive aspects. However, AChEI showed better effects in improving the global state, with donepezil being the most effective treatment. Nonetheless, there was no evidence of improvement in behavioral disturbances with the use of AChEI.
Article
Medicine, General & Internal
Mariola Herbet, Jaroslaw Widelski, Iwona Piatkowska-Chmiel, Kamil Pawlowski, Aleksandra Dymek, Tomasz Mroczek
Summary: This study evaluated the safety and pharmacological activity of compounds obtained from various plant extracts, and found that these compounds have a high safety profile and significantly improve rodent memory.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Pooja Mittal, Rajat Goyal, Ramit Kapoor, Chunpeng Wan, Rupesh K. Gautam
Summary: Phytochemicals or natural products have been extensively studied for their potential in treating neurodegenerative diseases like Parkinson's disease and Alzheimer's disease. Despite having knowledge of the molecular pathways involved, little progress has been made in the treatment of these diseases. Natural products, however, have shown promise as neuroprotective agents and this review discusses their therapeutic potential.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Sharanjot Kaur, Harkomal Verma, Sukhchain Kaur, Prabhakar Gangwar, Anuradha Yadav, Bharti Yadav, Rashmi Rao, Monisha Dhiman, Anil Kumar Mantha
Summary: miRNAs regulate gene expression and have multiple roles in biological processes and human diseases. In Alzheimer's disease (AD), miRNA dysregulation is associated with the clearance of amyloid beta and tau and the regulation of neuroinflammation. Several miRNAs related to AD are associated with cell cycle regulation, immune system, stress responses, cellular senescence, nerve growth factor signaling, and synaptic regulation. Phytochemicals can alter the expression of miRNAs and may serve as therapeutic agents for AD.
METABOLIC BRAIN DISEASE
(2023)
Article
Clinical Neurology
Clara Vila-Castelar, Pierre N. Tariot, Kaycee M. Sink, David Clayton, Jessica B. Langbaum, Ronald G. Thomas, Yinghua Chen, Yi Su, Kewei Chen, Nan Hu, Margarita Giraldo-Chica, Carlos Tobon, Natalia Acosta-Baena, Ernesto Luna, Marisol Londono, Paula Ospina, Victoria Tirado, Claudia Munoz, Eliana Henao, Yamile Bocanegra, Sergio Alvarez, Silvia Rios-Romenets, Valentina Ghisays, Dhruman Goradia, Wendy Lee, Ji Luo, Michael H. Malek-Ahmadi, Hillary D. Protas, Francisco Lopera, Eric M. Reiman, Yakeel T. Quiroz
Summary: This study examined the effect of sex on pathology, neurodegeneration, and memory in cognitively-unimpaired individuals with and without the Presenilin-1 (PSEN1) E280A mutation. The results suggest that females may have greater cognitive resilience to AD pathology and neurodegeneration than males.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Emma M. Coomans, Jori Tomassen, Rik Ossenkoppele, Betty M. Tijms, Luigi Lorenzini, Mara ten Kate, Lyduine E. Collij, Fiona Heeman, Roos M. Rikken, Sophie M. van der Landen, Marijke E. den Hollander, Sandeep S. Golla, Maqsood Yaqub, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Eco J. C. de Geus, Pieter Jelle Visser, Bart N. M. van Berckel, Anouk den Braber
Summary: The amyloid cascade hypothesis has played a significant role in Alzheimer's disease research and clinical trial designs. This study investigated the relationship between amyloid-beta and tau at the individual and twin-pair levels, aiming to rule out genetic and shared environmental effects as confounders. The findings suggest that the associations between amyloid-beta, tau, neurodegeneration, and cognition are unbiased by genetic factors, and the effects of amyloid-beta on neurodegeneration and cognitive decline are mediated by tau.
Article
Nutrition & Dietetics
Andrzej Jaskiewicz, Grazyna Budryn, Miguel Carmena-Bargueno, Horacio Perez-Sanchez
Summary: The study found that sesquiterpene lactones in chicory extracts have a strong inhibitory effect on acetylcholinesterase, especially lactucopicrin. Different chicory extracts exhibit complementary patterns in binding the AChE active site.
Editorial Material
Multidisciplinary Sciences
Ian H. Guldner, Tony Wyss-Coray
Summary: An analysis of mice with tau protein, a key feature of Alzheimer's disease, demonstrates that immune cells work together to cause tau-mediated neurodegeneration, and that existing clinic drugs can combat this decline.
Review
Biochemistry & Molecular Biology
Davide Decandia, Francesca Gelfo, Eugenia Landolfo, Francesca Balsamo, Laura Petrosini, Debora Cutuli
Summary: Alzheimer's disease (AD) is a growing epidemic with significant social and economic burden. Inflammation and neurodegeneration play a major role in AD pathogenesis. This review focuses on the effects of dietary supplementation in AD-like animal models, specifically in relation to neuroinflammation induced by lipopolysaccharide (LPS) injection. Various compounds, such as curcumin and krill oil, have been found to counteract cognitive decline and neuroinflammatory responses in rodents. Overall, dietary interventions offer potential neuroprotection and immune regulation in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dorit Trudler, Swagata Ghatak, Stuart A. Lipton
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease, represent a significant social and economic burden due to increasing prevalence and lack of effective therapies. Lack of reliable models has hindered the development of treatments, but human-induced pluripotent stem cell technology offers a promising alternative to complement animal models for disease modeling and drug discovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Christoph Helmstaedter, Teresa Lutz, Vinzent Wolf, Juri-Alexander Witt
Summary: This study aimed to determine the prevalence of dementia diagnoses among patients at a large university epilepsy center. The findings showed that the prevalence of dementia in epilepsy is relatively low. However, the risk of dementia is higher in the elderly, in late-onset epilepsies, and when comorbid risk factors exist. Seizures can also be an early sign of a neurodegenerative disease. Future research should focus on screening for dementia in patients with epilepsy and stratifying them based on underlying pathologies and comorbidities.
FRONTIERS IN NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Md. Tanvir Kabir, Md. Sahab Uddin, Sonia Zaman, Md. Sohanur Rahman, Tapan Behl, Ausaf Ahmad, Abdul Hafeez, Asma Perveen, Ghulam Md. Ashraf
Summary: Alzheimer's disease is an age-related neurodegenerative disorder that affects cognitive functions, with neuroinflammation and amyloid-beta deposition playing key roles. Effective therapeutic approaches are urgently needed, as current drugs only provide symptomatic treatment. Phytochemicals with anti-neuroinflammatory effects show promise in AD treatment.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Ilaria Piccialli, Valentina Tedeschi, Lucia Caputo, Stefano D'Errico, Roselia Ciccone, Vincenzo De Feo, Agnese Secondo, Anna Pannaccione
Summary: Alzheimer's disease is characterized by memory loss and cognitive impairment, with multiple hypotheses proposed to explain its etiology including A beta aggregation, tau hyperphosphorylation, neuroinflammation, and oxidative stress. However, traditional single-target drug therapies have been unsuccessful in halting the brain function deterioration. A multi-target approach and lifestyle interventions targeting modifiable risk factors associated with aging are currently of great interest in Alzheimer's treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Deepika Purohit, Pawan Jalwal, Deeksha Manchanda, Sapna Saini, Ravinder Verma, Deepak Kaushik, Vineet Mittal, Manish Kumar, Tanima Bhattacharya, Md. Habibur Rahman, Rohit Dutt, Parijat Pandey
Summary: The article provides a review of the formulation techniques and biomedical applications of nanocapsules (NCs). NCs are considered as an effective drug delivery system due to their controlled drug release and site-specific delivery properties. Various techniques can be used to formulate NCs, and their pharmaceutical performance can be evaluated using different analytical techniques.
RECENT PATENTS ON NANOTECHNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Neha Minocha, Nidhi Sharma, Ravinder Verma, Deepak Kaushik, Parijat Pandey
Summary: Solid lipid nanoparticles (SLNs) are a solid-state drug nano delivery system that can improve solubility and bioavailability for enhanced therapeutic effects. SLNs can be administered via various routes with high stability and low cost, and are suitable for both lipophilic and hydrophilic drugs.
RECENT PATENTS ON NANOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Javed Ahmed, Mohsin Abbas Khan, Muhammad Ehsan Khalid, Irshad Ahmad, Irfan Pervaiz, Umair Khurshid, Saharish Khaliq, Kashif ur Rehman Khan, Muhammad Adeel Arshad, Ghadeer M. M. Albadrani, Ahmed E. E. Altyar, Amany A. Sayed, Mousa O. Germoush, Mohamed M. Abdel-Daim
Summary: The study synthesized and characterized different metformin derivatives with potent antidiabetic potential and minimal side-effects. Metal complexes containing Cu II and Zn II were generated using aromatic aldehydes and ketones, and characterized through various techniques. The derivatives showed significant antidiabetic activities against targeted enzymes and hold promise for future study and development.
Article
Immunology
Siyab Khan, Muhammad Rizwan, Adnan Zeb, Muhammad Alaa Eldeen, Said Hassan, Ashfaq Ur Rehman, Refaat A. Eid, Mohamed Samir A. Zaki, Ghadeer M. Albadrani, Ahmed E. Altyar, Nehal Ahmed Talaat Nouh, Mohamed M. Abdel-Daim, Amin Ullah
Summary: This study identified 6 antigenic proteins and designed a multi-epitope subunit vaccine, which showed strong immunogenicity and stability through simulation and validation. However, further confirmation of its safety and efficacy is needed.
Article
Pharmacology & Pharmacy
Ammara Saleem, Izza Hameed, Muhammad Furqan Akhtar, Ghulam Md Ashraf, Badrah S. Alghamdi, Md. Habibur Rahman, Majed N. Almashjary
Summary: This research validated the folkloric use of Quercus leucotrichophora (QL) leaf extracts against inflammation and arthritis, and determined the chemical composition using HPLC. The study found that QL leaf extracts exhibited significant antioxidant, anti-inflammatory, and anti-arthritic potential, possibly due to the presence of quercetin, gallic acid, sinapic acid, and ferulic acid.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Afnan Afnan, Ammara Saleem, Muhammad Furqan Akhtar
Summary: This study aimed to evaluate the anti-inflammatory and anti-arthritic potential of Chrysin (CR), a natural dietary flavone found in plants such as Passiflora and Propalis, and honey. The results showed that treatment with CR, especially in combination with MTX, improved CFA-induced arthritis due to its significant antioxidant, analgesic, and anti-inflammatory effects.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Maira Javed, Ammara Saleem, Muhammad Furqan Akhtar
Summary: This study aimed to investigate the anti-inflammatory and anti-arthritic potential of diosgenin alone and in combination with methotrexate (MTX). The results showed that diosgenin exhibited high antioxidant and anti-arthritic activity in vitro, and showed anti-inflammatory effects by reducing inflammation and improving blood parameters in vivo. The combination of diosgenin and MTX had the best therapeutic efficacy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Amna Tahir, Muhammad Furqan Akhtar, Ammara Saleem, Muhammad Naveed, Basiru Olaitan Ajiboye, Fareeha Anwar, Aslam Khan
Summary: PCCR is a traditional herbal medicine used for treating muscular swelling, inflammation, pain, and fever. This study confirmed the anti-inflammatory, analgesic, and neuroprotective effects of PCCR in arthritic rats. PCCR exhibited antioxidant and anti-inflammatory activities, improved oxidative stress, and reduced inflammatory markers in rats with arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Hafiz Muhammad Zubair, Muhammad Arslan Khan, Faisal Gulzar, Musaed Alkholief, Abdul Malik, Suhail Akhtar, Ali Sharif, Muhammad Furqan Akhtar, Muhammad Abbas
Summary: This study aims to explore the experiences of NSCLC patients receiving palliative chemotherapy and their adaptation to post-chemotherapy life, beliefs, and quality of life. Through face-to-face interviews, the patients' experiences were categorized into five themes, revealing the importance of shared decision-making between clinicians and patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Zahid Khan, Abul Kalam Azad, Saleem Jan, Muhammad Safdar, Shabana Bibi, Amin Malik Shah Abdul Majid, Ghadeer M. Albadrani, Nehal Ahmed Talaat Nouh, Jawaher A. Abdulhakim, Mohamed M. Abdel-Daim
Summary: The essential oil of Urtica dioica L. whole plant was evaluated for its antioxidant, phytotoxic, and antibacterial activities using GC-MS technique. The analysis identified various constituents and demonstrated potential antioxidant effects and antibacterial activity against selected pathogens. Protein-ligand docking study further correlated docking results with experimental analysis and provided insight for further investigation.
Review
Pharmacology & Pharmacy
Diksha Nagpal, Ravinder Verma, Vineet Mittal, Philippe Jeandet, Deepak Kaushik
Summary: Breast cancer is a common disease with various treatment options, including chemotherapy, surgery, and radiotherapy. However, chemotherapy drugs have limitations. Nanomedicine drugs have emerged as a promising alternative for breast cancer treatment, along with the development of immunotherapies and cancer vaccines.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ahmed E. Altyar, Osama A. Kensara, Amany A. Sayed, Lotfi Aleya, Mikhlid H. Almutairi, Mohamed Sayed Zaazouee, Alaa Ahmed Elshanbary, Fatma M. El-Demerdash, Mohamed M. Abdel-Daim
Summary: The study evaluated the potential protective effects of morin against acute AFB1-induced hepatic and cardiac toxicity. The results showed that morin significantly decreased the levels of certain serum markers and exerted protective effects on hepatic and cardiac parameters.
Article
Environmental Sciences
Sadaf Yasmeen, Aslam Khan, Fareeha Anwar, Muhammad Furqan Akhtar, Sidra Yasmeen, Shafeeq Ali Shah
Summary: This study aimed to examine the antifibrotic effect of direct-acting antiviral drugs Sofosbuvir and Velpatasvir in a rat model of carbon tetrachloride-induced fibrosis. The results showed that Sofosbuvir and Velpatasvir, alone or in combination, significantly inhibited fibrosis and mediated this effect by reducing the levels of TNF-a/NF-& kappa;B and the IL-6 signaling pathway. Therefore, Sofosbuvir and Velpatasvir may have antifibrotic effects independent of their antiviral activity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Medicine, General & Internal
Ummara Altaf, Zikria Saleem, Muhammad Furqan Akhtar, Waleed Mohammad Altowayan, Abdulmajeed A. Alqasoumi, Mohammed Salem Alshammari, Abdul Haseeb, Fahad Raees, Mohammad Tarique Imam, Narjis Batool, Muhammad Masoom Akhtar, Brian Godman
Summary: Culture sensitivity reports were used in a teaching hospital in Pakistan to optimize antibiotic prescribing. The adjustment of empiric therapy based on the reports led to a reduction in antibiotic utilization and costs, as well as improved treatment selection. The study highlights the importance of implementing antimicrobial stewardship programs and hospital antibiotic guidelines to minimize unnecessary use of broad-spectrum antibiotics.
MEDICINA-LITHUANIA
(2023)
