Journal
MOLECULES
Volume 19, Issue 9, Pages 14266-14272Publisher
MDPI AG
DOI: 10.3390/molecules190914266
Keywords
Thymelaeaceae; Daphne holosericea; guaiane sesquiterpenoids; acetylcholinesterase inhibition
Funding
- National Natural Science Foundation of China [31300294]
- Special Fund for Agro-scientific Research in the Public Interest [201303117]
- National Support Science and Technology Subject [2013BAI11B04]
- Fundamental Scientific Research Funds for CATAS [ITBB110301, ITBB140401]
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Two new sesquiterpenoids with guaiane skeletons-holosericin A (1) and holosericin B (2)-were isolated from the medicinal plant Daphne holosericea (Diels) Hamawa (Thymelaeceae). Their structures were elucidated by 1D and 2D-NMR spectroscopy, as well as HR-ESI-MS data. Compounds 1 and 2 were evaluated for inhibitory activities against acetylcholinesterase and compound 2 showed a moderate activity with 31% inhibition.
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