Journal
MOLECULES
Volume 17, Issue 12, Pages 15013-15021Publisher
MDPI
DOI: 10.3390/molecules171215013
Keywords
Valeriana amurensis; germacrane-type sesquiterpenoids; heishuixiecaoline; lignans; PC 12 cell
Funding
- Program of International S&T Cooperation of China [2010DFA32440]
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Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (A beta(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against A beta-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
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