Article
Biochemistry & Molecular Biology
Chengxing Qiu, Liping Mu, Ji Wang, Ran Tang, Bo Hou, Weiyan Hu, Rongping Zhang, Xinglong Chen
Summary: The purpose of this study was to identify sesquiterpenoids from Alpinia oxyphylla Miq. fruits using LC-MS and evaluate their neuroprotective effects on H2O2-induced SH-SY5Y cells. A total of 35 sesquiterpenoids, including 10 previously unreported ones, were isolated from A. oxyphylla fruits. The results showed that certain compounds demonstrated neuroprotective effects by improving cell viability and reducing oxidative stress markers.
Article
Geriatrics & Gerontology
Peng Zeng, Yuan-Cheng Liu, Xiao-Ming Wang, Chao-Yuan Ye, Yi-Wen Sun, Hong-Fei Su, Shuo-Wen Qiu, Ya-Nan Li, Yao Wang, Yan-Chun Wang, Jun Ma, Man Li, Qing Tian
Summary: The dried and ripe fruits of Alpinia oxyphylla have been widely used in treating dementia. This study investigated the targets of Alpinia oxyphylla in tonifying kidney-essence and nourishing intelligence and identified key phytochemicals that regulate the pathogenesis of neurodegenerative dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Chunlian Li, Xiaobin Lin, Qiuyang Cai, Weicheng Zhang, Xianyi Wu, Zekai Tan, Lewen Yao, Shiyuan Huang, Yanghe Yuan, Lanyue Zhang
Summary: The essential oil of Alpinia oxyphylla has antioxidant and antibacterial activities, as well as anti-inflammatory effects on TPA-induced ear edema. Its potential distribution in China includes over 12 provinces, with the most extensive in Hainan province.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2022)
Article
Chemistry, Medicinal
Shuyu Xu, Xiaoyun Ji, Zheng Shi, Xin Chen, Rui Tan, Hezhong Jiang
Summary: Currently, the aging population is increasing globally, leading to serious impacts of neurodegenerative disorders on society and patients. Alpinia oxyphylla Miq., a Traditional Chinese Medicine used for treating vomiting, has been newly found to possess neuroprotective effects. This study analyzed the chemical constituents of the ethyl acetate extract fraction from dried fruits of A. oxyphylla, resulting in the isolation of 15 compounds, including three newly identified ones. The neuroprotective effect of chrysin was confirmed through experiments using glutamate-induced PC12 cells.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2023)
Article
Cell Biology
Yacong He, Shuang Chen, Bun Tsoi, Shuhua Qi, Bing Gu, Zhenxing Wang, Cheng Peng, Jiangang Shen
Summary: The study found that by inducing the BDNF signaling pathway, AOM can promote adult hippocampal neurogenesis and improve cognitive impairments after stroke. P-CA is identified as the most effective compound in AOM, with the ability to activate the BDNF/TrkB/AKT signaling pathway and promote NSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Applied
Fapetu Kemi Busayo, Jin-Ling Yang, Xu-Po Ding, Ya-Li Wang, Cui-Juan Gai, Fei Wu, Hao-Fu Dai, Wen-Li Mei, Hui-Qin Chen
Summary: In this study, the chemical constituents and bioactivities of the unpolar fractions of Alpinia oxyphylla Miq. were analyzed. The main compounds, nootkatone and valencene, were found in the fractions extracted from the fruits and leaves. The results showed that nootkatone exhibited tyrosinase inhibitory and inhibitory effects on NO production, while valencene only showed inhibitory activity on NO production. Additionally, the critical genes involved in nootkatone biosynthesis were identified from transcriptome datasets.
NATURAL PRODUCT RESEARCH
(2023)
Article
Genetics & Heredity
Lin Yuan, Kun Pan, Yonghui Li, Bo Yi, Bingmiao Gao
Summary: Differentially expressed genes (DEGs) and metabolic pathways related to flavonoids biosynthesis in Alpinia oxyphylla were identified in roots, leaves, and different stages of fruits. Up-regulation of 9 DEGs was observed in fruits, while 11 DEGs were highly up-regulated in roots compared with leaves.
Article
Integrative & Complementary Medicine
Chin-Yi Cheng, Su-Yin Chiang, Shung-Te Kao, Shang-Chih Huang
Summary: This study showed that Alpinia oxyphylla Miq extract treatment reduced cerebral infarction and improved neurological deficits in rats with cerebral ischemia-reperfusion injury. The beneficial effects were attributed to the downregulation of JNK-mediated inflammatory signaling in the penumbral cortex.
Article
Integrative & Complementary Medicine
Li Ying, Deli Wang, Guankui Du
Summary: The study investigated the bioactive components of different tissues of A. oxyphylla and found that flavonols are abundant in the fruit, flavonols and phenolic acids are enriched in the roots, and flavonols, phenolic acids, and tannins are abundant in the leaves. Network pharmacology analysis showed that flavonoids are most important in the fruit, while phenolic acids are crucial in the roots and leaves, indicating high medicinal value in each tissue.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Yueh-Ting Tsai, Hui-Chi Huang, Shung-Te Kao, Tung-Ti Chang, Chin-Yi Cheng
Summary: This study found that Alpinia oxyphylla Miq (AOM) has a protective effect against cell apoptosis after transient middle cerebral artery occlusion (MCAo), and it achieves this by regulating the signaling pathways within the cells. AOM inhibits mitochondria-related apoptosis and promotes cell survival.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Neurosciences
Shuang Wu, Yan-Feng Zhang, Yue Gui, Tian Jiang, Cheng-Mei Zhou, Jing-Yi Li, Jia-Le Suo, Yong-Nan Li, Rui-Lin Jin, Shu-Lei Li, Jia-Yue Cui, Bai-Hong Tan, Yan-Chao Li
Summary: In this study, a new method for detecting neuronal death using two membrane-bound dyes, rhodamine R6 and DiOC6(3), was reported. The staining pattern produced by this method is similar to Fluoro-Jade B in kainic acid-damaged brains in mice. The increased staining of rhodamine R6 and DiOC6(3) is associated with increased levels of phospholipids and free cholesterol in the perinuclear cytoplasm of damaged neurons.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Tomas T. Roos, Megg G. Garcia, Isak Martinsson, Rana Mabrouk, Bodil Israelsson, Tomas Deierborg, Asgeir Kobro-Flatmoen, Heikki Tanila, Gunnar K. Gouras
Summary: Research suggests that intracellular A beta plays a crucial role in the prion-like spread of Alzheimer's disease, leading to plaque formation and neuronal damage.
ACTA NEUROPATHOLOGICA
(2021)
Article
Biochemistry & Molecular Biology
Mengshi Wang, Fei Lin, Xiaoying Zhang, Ming Zhang, Tingxu Yan, Bo Wu, Yiyang Du, Bosai He, Ying Jia
Summary: This study demonstrated the anti-Alzheimer's disease effect of the combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus (AS), which reduced Aβ1-42 levels and affected the expression of BACE1, exerting a neuroprotective effect against aluminum-induced AD.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Bo Wu, Anna Gan, Ruixuan Wang, Fei Lin, Tingxu Yan, Ying Jia
Summary: This study aimed to investigate the antidepressant effect and underlying mechanism of Alpinia oxyphylla Miq. volatile oil (AOVO) in mice subjected to chronic unpredictable mild stress (CUMS). The results showed that AOVO improved depressive behaviors and reduced neuroinflammation by suppressing the TLR4-mediated MyD88/NF-κB signaling pathway.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Biochemistry & Molecular Biology
Gayle Doherty, Alison Holiday, Yasaman Malekizadeh, Cosmin Manolescu, Stephen Duncan, Iona Flewitt, Kirsty Hamilton, Beth MacLeod, James A. Ainge, Jenni Harvey
Summary: Key pathological features of Alzheimer's disease (AD) include the accumulation of amyloid beta (Aβ) and metabolic dysfunction. Impairments in the leptin system have been detected in AD patients, sparking interest in targeting this system for AD treatment. This study examines the cognitive enhancing and neuroprotective actions of six-amino acid peptides derived from leptin(116-130) in promoting synaptic plasticity and improving memory tasks. The hexamers replicate the effects of leptin in promoting AMPA receptor trafficking and preventing toxic effects of Aβ on hippocampal synapses and neuronal viability. These findings further support leptin and leptin-derived peptides as potential therapeutics for AD.
JOURNAL OF NEUROCHEMISTRY
(2023)